Search Results - "Celly, Chander S"

A novel, orally active CXCR1/2 receptor antagonist, Sch527123, inhibits neutrophil recruitment, mucus production, and goblet cell hyperplasia in animal models of pulmonary inflammation by Chapman, Richard W, Minnicozzi, Michael, Celly, Chander S, Phillips, Jonathan E, Kung, Ted T, Hipkin, R William, Fan, Xuedong, Rindgen, Diane, Deno, Gregory, Bond, Richard, Gonsiorek, Waldemar, Billah, Motasim M, Fine, Jay S, Hey, John A

“…Sch527123 [2-hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]ben-zamide] is a potent, selective…”
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Discovery of oral and inhaled PDE4 inhibitors by Ting, Pauline C., Lee, Joe F., Kuang, Rongze, Cao, Jianhua, Gu, Danlin, Huang, Ying, Liu, Zhidan, Aslanian, Robert G., Feng, Kung-I., Prelusky, Daniel, Lamca, James, House, Aileen, Phillips, Jonathan E., Wang, Peng, Wu, Ping, Lundell, Daniel, Chapman, Richard W., Celly, Chander S.

“…The optimization of oxazole-based PDE4 inhibitor 1 has led to the identification of both oral (compound 16) and inhaled (compound 34) PDE4 inhibitors…”
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Discovery of oxazole-based PDE4 inhibitors with picomolar potency by Kuang, Rongze, Shue, Ho-Jane, Xiao, Li, Blythin, David J., Shih, Neng-Yang, Chen, Xiao, Gu, Danlin, Schwerdt, John, Lin, Ling, Ting, Pauline C., Cao, Jianhua, Aslanian, Robert, Piwinski, John J., Prelusky, Daniel, Wu, Ping, Zhang, Ji, Zhang, Xiang, Celly, Chander S., Billah, Motasim, Wang, Peng

“…Optimization of oxazole-based PDE4 inhibitors has led to the discovery of a series of quinolyl oxazoles, with 4-benzylcarboxamide and 5-α-aminoethyl groups…”
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Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors by Kuang, Rongze, Shue, Ho-Jane, Blythin, David J., Shih, Neng-Yang, Gu, Danlin, Chen, Xiao, Schwerdt, John, Lin, Ling, Ting, Pauline C., Zhu, Xiaohong, Aslanian, Robert, Piwinski, John J., Xiao, Li, Prelusky, Daniel, Wu, Ping, Zhang, Ji, Zhang, Xiang, Celly, Chander S., Minnicozzi, Michael, Billah, Motasim, Wang, Peng

“…Substituted quinolyl oxazoles were discovered as a novel and highly potent series of phosphodiesterase 4 (PDE4) inhibitors. Structure–activity relationship…”
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Temporal profile of forced expiratory lung function in allergen-challenged Brown–Norway rats by Celly, Chander S., House, Aileen, Sehring, Susan J., Zhang, Xiang Y., Jones, Howard, Hey, John A., Egan, Robert W., Chapman, Richard W.

“…The Brown–Norway rat is often used to study the allergic pulmonary response. However, relatively little is known about the delayed phase reactions after…”
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Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate by Skeans, Susan, Lamca, James E, House, Aileen, Celly, Chander S, Hey, John A, Chapman, Richard W

“…Airway closure is frequently observed in human asthma. However, limited information exists on the factors that cause this condition. In this study, an allergic…”
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