Search Results - "Cellular and Molecular Biology"

Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis by Liu, Pengfei, Feng, Yetong, Li, Hanwei, Chen, Xin, Wang, Guangsuo, Xu, Shiyuan, Li, Yalan, Zhao, Lei

“…Ferroptosis is a newly recognized type of cell death, which is different from traditional necrosis, apoptosis or autophagic cell death. However, the position…”
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Progress in research on paclitaxel and tumor immunotherapy by Zhu, Linyan, Chen, Liqun

“…Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs…”
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p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation by Liu, Wei Jing, Ye, Lin, Huang, Wei Fang, Guo, Lin Jie, Xu, Zi Gan, Wu, Hong Luan, Yang, Chen, Liu, Hua Feng

“…The ubiquitin-proteasome system (UPS) and autophagy are two distinct and interacting proteolytic systems. They play critical roles in cell survival under…”
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Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2/Keap1/xCT signaling by Fu, Dazhi, Wang, Chunxiao, Yu, Lei, Yu, Rui

“…Currently, resistance against cisplatin (DDP) is a frequent problem for the success of advanced gastric carcinoma (GC) chemotherapy. Here, we sought to…”
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Transcriptome profiling revealed multiple genes and ECM-receptor interaction pathways that may be associated with breast cancer by Bao, Yulong, Wang, Li, Shi, Lin, Yun, Fen, Liu, Xia, Chen, Yongxia, Chen, Chen, Ren, Yanni, Jia, Yongfeng

“…Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms…”
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Beyond K48 and K63: non-canonical protein ubiquitination by Tracz, Michal, Bialek, Wojciech

“…Protein ubiquitination has become one of the most extensively studied post-translational modifications. Originally discovered as a critical element in highly…”
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The role of macrophage subtypes and exosomes in immunomodulation by Gharavi, Abdulwahab Teflischi, Hanjani, Niloofar Asadi, Movahed, Elaheh, Doroudian, Mohammad

“…Abstract Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell…”
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The usefulness of lactate dehydrogenase measurements in current oncological practice by Forkasiewicz, Agata, Dorociak, Maja, Stach, Kamilla, Szelachowski, Piotr, Tabola, Renata, Augoff, Katarzyna

“…One of the hallmarks of cancer cells is increased energy requirements associated with the higher rate of cellular proliferative activity. Metabolic changes in…”
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STAT3, stem cells, cancer stem cells and p63 by Galoczova, Michaela, Coates, Philip, Vojtesek, Borivoj

“…Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed…”
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The role of polyphenols in overcoming cancer drug resistance: a comprehensive review by Maleki Dana, Parisa, Sadoughi, Fatemeh, Asemi, Zatollah, Yousefi, Bahman

“…Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading to…”
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Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines by Liang, Wenqing, Chen, Xiaozhen, Zhang, Songou, Fang, Jian, Chen, Meikai, Xu, Yifan, Chen, Xuerong

“…Mesenchymal stem cells (MSCs) show homing capacity towards tumor sites. Numerous reports indicate that they are involved in multiple tumor-promoting processes…”
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Exosomal lncRNA TUG1 from cancer-associated fibroblasts promotes liver cancer cell migration, invasion, and glycolysis by regulating the miR-524-5p/SIX1 axis by Lu, Le, Huang, Jingjing, Mo, Jiantao, Da, Xuanbo, Li, Qiaoxin, Fan, Meng, Lu, Hongwei

“…Increasing evidence suggests that taurine upregulated gene 1 (TUG1) is crucial for tumor progression; however, its role in hepatocellular carcinoma (HCC) and…”
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Osteoporosis pathogenesis and treatment: existing and emerging avenues by Liang, Bo, Burley, George, Lin, Shu, Shi, Yan-Chuan

“…Abstract Osteoporotic fractures lead to increased disability and mortality in the elderly population. With the rapid increase in the aging population around…”
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METTL16 promotes hepatocellular carcinoma progression through downregulating RAB11B-AS1 in an m6A-dependent manner by Dai, Yun-zhang, Liu, Yong-da, Li, Jie, Chen, Mei-ting, Huang, Mei, Wang, Fang, Yang, Qing-song, Yuan, Ji-hang, Sun, Shu-han

“…Abstract Background The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic…”
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MiR-7-5p suppresses tumor metastasis of non-small cell lung cancer by targeting NOVA2 by Xiao, Haiping

“…Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Distant metastasis is thought to be one of the most important factors…”
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Anti-cancer peptide-based therapeutic strategies in solid tumors by Karami Fath, Mohsen, Babakhaniyan, Kimiya, Zokaei, Maryam, Yaghoubian, Azadeh, Akbari, Sadaf, Khorsandi, Mahdieh, Soofi, Asma, Nabi-Afjadi, Mohsen, Zalpoor, Hamidreza, Jalalifar, Fateme, Azargoonjahromi, Ali, Payandeh, Zahra, Alagheband Bahrami, Armina

“…Nowadays, conventional medical treatments such as surgery, radiotherapy, and chemotherapy cannot cure all types of cancer. A promising approach to treat solid…”
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Cells of human breast milk by Witkowska-Zimny, Malgorzata, Kaminska-El-Hassan, Ewa

“…Human milk is a complex fluid that has developed to satisfy the nutritional requirements of infants. In addition to proteins, lipids, carbohydrates and other…”
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MicroRNA let-7 and viral infections: focus on mechanisms of action by Letafati, Arash, Najafi, Sajad, Mottahedi, Mehran, Karimzadeh, Mohammad, Shahini, Ali, Garousi, Setareh, Abbasi-Kolli, Mohammad, Sadri Nahand, Javid, Tamehri Zadeh, Seyed Saeed, Hamblin, Michael R, Rahimian, Neda, Taghizadieh, Mohammad, Mirzaei, Hamed

“…MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical cellular processes, a number of which are involved in host defense…”
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The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies by Zalpoor, Hamidreza, Akbari, Abdullatif, Samei, Azam, Forghaniesfidvajani, Razieh, Kamali, Monireh, Afzalnia, Azadeh, Manshouri, Shirin, Heidari, Fatemeh, Pornour, Majid, Khoshmirsafa, Majid, Aazami, Hossein, Seif, Farhad

“…The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to…”
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The role of different SIRT1-mediated signaling pathways in toxic injury by Ren, Zhihua, He, Hongyi, Zuo, Zhicai, Xu, Zhiwen, Wei, Zhanyong, Deng, Junliang

“…Common environmental pollutants and drugs encountered in everyday life can cause toxic damage to the body through oxidative stress, inflammatory stimulation,…”
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