Search Results - "Cell research"

Ferroptosis: molecular mechanisms and health implications by Tang, Daolin, Chen, Xin, Kang, Rui, Kroemer, Guido

“…Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012,…”
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Cuproptosis: a copper-triggered modality of mitochondrial cell death by Tang, Daolin, Chen, Xin, Kroemer, Guido

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Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion by Xia, Shuai, Liu, Meiqin, Wang, Chao, Xu, Wei, Lan, Qiaoshuai, Feng, Siliang, Qi, Feifei, Bao, Linlin, Du, Lanying, Liu, Shuwen, Qin, Chuan, Sun, Fei, Shi, Zhengli, Zhu, Yun, Jiang, Shibo, Lu, Lu

“…The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To…”
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The molecular machinery of regulated cell death by Tang, Daolin, Kang, Rui, Berghe, Tom Vanden, Vandenabeele, Peter, Kroemer, Guido

“…Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly…”
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Immune checkpoint signaling and cancer immunotherapy by He, Xing, Xu, Chenqi

“…Immune checkpoint blockade therapy has become a major weapon in fighting cancer. Antibody drugs, such as anti-PD-1 and anti-PD-L1, demonstrate obvious…”
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The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression by Lei, Guang, Zhang, Yilei, Koppula, Pranavi, Liu, Xiaoguang, Zhang, Jie, Lin, Steven H., Ajani, Jaffer A., Xiao, Qin, Liao, Zhongxing, Wang, Hui, Gan, Boyi

“…Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that…”
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Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression by Wang, Xinyi, Sun, Guangqiang, Feng, Teng, Zhang, Jing, Huang, Xun, Wang, Tao, Xie, Zuoquan, Chu, Xingkun, Yang, Jun, Wang, Huan, Chang, Shuaishuai, Gong, Yanxue, Ruan, Lingfei, Zhang, Guanqun, Yan, Siyuan, Lian, Wen, Du, Chen, Yang, Dabing, Zhang, Qingli, Lin, Feifei, Liu, Jia, Zhang, Haiyan, Ge, Changrong, Xiao, Shifu, Ding, Jian, Geng, Meiyu

“…Recently, increasing evidence has suggested the association between gut dysbiosis and Alzheimer’s disease (AD) progression, yet the role of gut microbiota in…”
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Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy by Lv, Mengze, Chen, Meixia, Zhang, Rui, Zhang, Wen, Wang, Chenguang, Zhang, Yan, Wei, Xiaoming, Guan, Yukun, Liu, Jiejie, Feng, Kaichao, Jing, Miao, Wang, Xurui, Liu, Yun-Cai, Mei, Qian, Han, Weidong, Jiang, Zhengfan

“…CD8 + T cell-mediated cancer clearance is often suppressed by the interaction between inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes…”
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro by Wang, Manli, Cao, Ruiyuan, Zhang, Leike, Yang, Xinglou, Liu, Jia, Xu, Mingyue, Shi, Zhengli, Hu, Zhihong, Zhong, Wu, Xiao, Gengfu

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Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma by Peng, Junya, Sun, Bao-Fa, Chen, Chuan-Yuan, Zhou, Jia-Yi, Chen, Yu-Sheng, Chen, Hao, Liu, Lulu, Huang, Dan, Jiang, Jialin, Cui, Guan-Shen, Yang, Ying, Wang, Wenze, Guo, Dan, Dai, Menghua, Guo, Junchao, Zhang, Taiping, Liao, Quan, Liu, Yi, Zhao, Yong-Liang, Han, Da-Li, Zhao, Yupei, Yang, Yun-Gui, Wu, Wenming

“…Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To…”
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AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells by Wang, Shuai, Qiu, Zongyang, Hou, Yingnan, Deng, Xiya, Xu, Wei, Zheng, Tingting, Wu, Peihan, Xie, Shaofang, Bian, Weixiang, Zhang, Chong, Sun, Zewei, Liu, Kunpeng, Shan, Chao, Lin, Aifu, Jiang, Shibo, Xie, Youhua, Zhou, Qiang, Lu, Lu, Huang, Jing, Li, Xu

“…The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory…”
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Interaction between microbiota and immunity in health and disease by Zheng, Danping, Liwinski, Timur, Elinav, Eran

“…The interplay between the commensal microbiota and the mammalian immune system development and function includes multifold interactions in homeostasis and…”
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Mitochondrial metabolism and cancer by Porporato, Paolo Ettore, Filigheddu, Nicoletta, Pedro, José Manuel Bravo-San, Kroemer, Guido, Galluzzi, Lorenzo

“…Glycolysis has long been considered as the major metabolic process for energy production and anabolic growth in cancer cells. Although such a view has been…”
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CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA by Li, Shi-Yuan, Cheng, Qiu-Xiang, Liu, Jia-Kun, Nie, Xiao-Qun, Zhao, Guo-Ping, Wang, Jin

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Targeting immunometabolism as an anti-inflammatory strategy by Pålsson-McDermott, Eva M., O’Neill, Luke A. J.

“…The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic…”
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SARS-CoV-2 spike protein interacts with and activates TLR41 by Zhao, Yingchi, Kuang, Ming, Li, Junhong, Zhu, Ling, Jia, Zijing, Guo, Xuefei, Hu, Yaling, Kong, Jun, Yin, Hang, Wang, Xiangxi, You, Fuping

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RAB31 marks and controls an ESCRT-independent exosome pathway by Wei, Denghui, Zhan, Weixiang, Gao, Ying, Huang, Liyan, Gong, Run, Wang, Wen, Zhang, Ruhua, Wu, Yuanzhong, Gao, Song, Kang, Tiebang

“…Exosomes are generated within the multivesicular endosomes (MVEs) as intraluminal vesicles (ILVs) and secreted during the fusion of MVEs with the cell…”
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Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis by Zhou, Bo, Zhang, Jia-yuan, Liu, Xian-shuo, Chen, Hang-zi, Ai, Yuan-li, Cheng, Kang, Sun, Ru-yue, Zhou, Dawang, Han, Jiahuai, Wu, Qiao

“…Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death, such as…”
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Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion by He, Wan-ting, Wan, Haoqiang, Hu, Lichen, Chen, Pengda, Wang, Xin, Huang, Zhe, Yang, Zhang-Hua, Zhong, Chuan-Qi, Han, Jiahuai

“…Inflammasome is an intracellular signaling complex of the innate immune system. Activation of inflammasomes promotes the secretion of interleukin 1β (IL-1β)…”
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SARS-CoV-2 infects human neural progenitor cells and brain organoids by Zhang, Bao-Zhong, Chu, Hin, Han, Shuo, Shuai, Huiping, Deng, Jian, Hu, Ye-fan, Gong, Hua-rui, Lee, Andrew Chak-Yiu, Zou, Zijiao, Yau, Thomas, Wu, Wutian, Hung, Ivan Fan-Ngai, Chan, Jasper Fuk-Woo, Yuen, Kwok-Yung, Huang, Jian-Dong

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