Search Results - "Cell reports (Cambridge)"

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7 by Curran, Martin D., Roy, Sunando, Shaaban, Sharif, de Cesare, Mariateresa, Stark, Richard, Palmer, Steve, Jeffries, Aaron R., da Silva Filipe, Ana, Davis, Thomas, Collins, Jennifer, Williams, Thomas, Haldenby, Sam T., Cook, Kate, Davies, Robert, Kay, Sally, Poplawski, Radoslaw, Reynolds, Nicola, Moll, Robin J., Thornton, Alicia, Gatica-Wilcox, Bree, Louka, Stavroula F., Kraemer, Moritz U.G., Freeman, Timothy M., Abudahab, Khalil, Menegazzo, Mirko, Mason, Jenifer, Holmes, Alison, Curran, Tanya, Mookerjee, Siddharth, Munn, Robert, Davies, Alisha, Smith, Nikki, Cormie, Claire, Lo, Stephanie, Auckland, Cressida, Mollett, Guy, Harper, Katherine L., Bonner, Stephen, Padgett, Debra, Burton-Fanning, Shirelle, Bedford, Luke, Coupland, Lindsay, Wright, Victoria, Ball, Jonathan, Boswell, Tim, Duckworth, Nichola, Williams, Rebecca, Cogger, Benjamin J., Farr, Ben W., Thurston, Scott A.J., Bronner, Iraad F., Aigrain, Louise, Gallagher, Michael D., Miah, Shahjahan, Ramsay, Mary, Schaefer, Ulf, Manesis, Nikos, Allara, Elias, Nichols, Jenna, Vamos, Edith E., Hughes, Margaret, Wilson, Harry D., Wilson, Rebekah E., Thompson, Thomas, O’Brien, Sarah, Rudder, Steven, McCluggage, Kathryn, Bonfield, James, Liddle, Jennifier, Rowe, Will, Bevan, Paul, Clark, Richard, Cutts, Tim, Densem, Aiden, Dodd, David, Griffiths, Coline, Kay, Keely, Lensing, Stefanie, Lewis-Wade, Amanah, Mamun, Irfan, Martin, Matt, McClintock, Jo, Nathwani, Claire, Nicholson, Jon, Patel, Gaurang, Petersen, Arabella, Reynolds, Joe, Rudd, Luke, Sadri, Ramin, Sizer, Dale, Soria, Carmen Diaz, Sousa, Catarina, Squares, Janet, Stickland, Tim, Still, Ian, Symons, Edward, Uphill, James, Van, Philip Jansen, Voak, Paul, Corti, Davide

“…We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of…”
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The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity by Xie, Yangchun, Zhu, Shan, Song, Xinxin, Sun, Xiaofang, Fan, Yong, Liu, Jinbao, Zhong, Meizuo, Yuan, Hua, Zhang, Lin, Billiar, Timothy R., Lotze, Michael T., Zeh, Herbert J., Kang, Rui, Kroemer, Guido, Tang, Daolin

“…Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been…”
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells by Balka, Katherine R., Louis, Cynthia, Saunders, Tahnee L., Smith, Amber M., Calleja, Dale J., D’Silva, Damian B., Moghaddas, Fiona, Tailler, Maximilien, Lawlor, Kate E., Zhan, Yifan, Burns, Christopher J., Wicks, Ian P., Miner, Jonathan J., Kile, Benjamin T., Masters, Seth L., De Nardo, Dominic

“…Stimulator of Interferon Genes (STING) is a critical component of host innate immune defense but can contribute to chronic autoimmune or autoinflammatory…”
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Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells by Gu, Jian, Zhou, Jinren, Chen, Qiuyang, Xu, Xiaozhang, Gao, Ji, Li, Xiangyu, Shao, Qing, Zhou, Bo, Zhou, Haoming, Wei, Song, Wang, Qi, Liang, Yuan, Lu, Ling

“…Regulatory T (Treg) cells play a vital role in maintaining the immunosuppressive tumor microenvironment. Lactate is a crucial metabolite in cancer and is…”
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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers by Foltz, Steven M., Yu, Lihua, Ferguson, Martin L., Liu, Jia, Heiman, David I., Lawrence, Michael S., Saksena, Gordon, Dhankani, Varsha, Hegde, Apurva M., Li, Jun, Liu, Wenbin, Nissan, Moriah G., Sander, Chris, Wong, Christopher K., Ally, Adrian, Kasaian, Katayoon, Moore, Richard A., Cherniack, Andrew D., Meyerson, Matthew, Baylin, Stephen, Bootwalla, Moiz S., Hoadley, Katherine A., Mose, Lisle E., Hale, Walker, Morton, Donna, Santibanez, Jireh, Wheeler, David A., Fulton, Robert S., Wilson, Richard K., Penny, Robert, Gerken, Mark, Leraas, Kristen M., Huntsman, David, Duffy, Elizabeth R., Berkowitz, Ross, Malykh, Andrei, Iacocca, Mary, Roman-Roman, Sergio, Stern, Marc-Henri, Lipp, Eric, Sharp, Alexis, Delman, Keith, Owonikoko, Taofeek, Gillis, Ad, Korpershoek, Esther, Looijenga, Leendert, DiMeco, Francesco, Chen, Chu, Stoehr, Robert, Bubley, Glenn, Campo, Elias, Martignetti, John A., Breggia, Anne, Kocher, Jean-Pierre, Petersen, Gloria, Smyrk, Thomas, Ajani, Jaffer A., Esmaeli, Bita, Logothetis, Christopher, Rice, David, Sood, Anil, Kefford, Richard, Al-Ahmadie, Hikmat, Miller, Judy, Schiffman, Mark, Wentzensen, Nicolas, Caraman, Irina, Clipca, Adrian, Doruc, Serghei, Stancul, Irina, Albert, Monique, Arnaout, Angel, Bartlett, John, Engel, Jay, Urba, Walter, Marino, Mirella, Barnett, Gene, Farver, Carol, Abdel-Rahman, Mohamed H., Cebulla, Colleen M., Kumar, Bahavna, Rai, Karan, Lechan, Ronald, Graefen, Markus, Simon, Ronald, Tennstedt, Pierre, Glenn, Pat, Simko, Jeffry, Steele, Ruth, Campos, Benito, Rosenthal, Howard G., Adebamowo, Sally N., Giordano, Thomas, Moore, Kathleen, Moxley, Katherine, Shipman, Cassaundra, Wolf, Gregory, Ley, Timothy, Van Tine, Brian, Shmulevich, Ilya

“…Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using…”
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Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production by Sencio, Valentin, Barthelemy, Adeline, Tavares, Luciana P., Machado, Marina G., Soulard, Daphnée, Cuinat, Céline, Queiroz-Junior, Celso Martins, Noordine, Marie-Louise, Salomé-Desnoulez, Sophie, Deryuter, Lucie, Foligné, Benoit, Wahl, Céline, Frisch, Benoit, Vieira, Angelica T., Paget, Christophe, Milligan, Graeme, Ulven, Trond, Wolowczuk, Isabelle, Faveeuw, Christelle, Le Goffic, Ronan, Thomas, Muriel, Ferreira, Stéphanie, Teixeira, Mauro M., Trottein, François

“…Secondary bacterial infections often complicate viral respiratory infections. We hypothesize that perturbation of the gut microbiota during influenza A virus…”
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Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer by Wang, Yumeng, Xu, Xiaoyan, Maglic, Dejan, Dill, Michael T, Mojumdar, Kamalika, Ng, Patrick Kwok-Shing, Jeong, Kang Jin, Tsang, Yiu Huen, Moreno, Daniela, Bhavana, Venkata Hemanjani, Peng, Xinxin, Ge, Zhongqi, Chen, Hu, Li, Jun, Chen, Zhongyuan, Zhang, Huiwen, Han, Leng, Du, Di, Creighton, Chad J, Mills, Gordon B, Camargo, Fernando, Liang, Han

“…Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in…”
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Analysis of Single-Cell RNA-Seq Identifies Cell-Cell Communication Associated with Tumor Characteristics by Kumar, Manu P., Du, Jinyan, Lagoudas, Georgia, Jiao, Yang, Sawyer, Andrew, Drummond, Daryl C., Lauffenburger, Douglas A., Raue, Andreas

“…Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor interactions. Targeting ligand-receptor interactions (for instance,…”
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Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity by Sivick, Kelsey E., Desbien, Anthony L., Glickman, Laura Hix, Reiner, Gabrielle L., Corrales, Leticia, Surh, Natalie H., Hudson, Thomas E., Vu, Uyen T., Francica, Brian J., Banda, Tamara, Katibah, George E., Kanne, David B., Leong, Justin J., Metchette, Ken, Bruml, Jacob R., Ndubaku, Chudi O., McKenna, Jeffrey M., Feng, Yan, Zheng, Lianxing, Bender, Steven L., Cho, Charles Y., Leong, Meredith L., van Elsas, Andrea, Dubensky, Thomas W., McWhirter, Sarah M.

“…Intratumoral (IT) STING activation results in tumor regression in preclinical models, yet factors dictating the balance between innate and adaptive anti-tumor…”
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NAD+ Repletion Rescues Female Fertility during Reproductive Aging by Bertoldo, Michael J., Listijono, Dave R., Ho, Wing-Hong Jonathan, Riepsamen, Angelique H., Goss, Dale M., Richani, Dulama, Jin, Xing L., Mahbub, Saabah, Campbell, Jared M., Habibalahi, Abbas, Loh, Wei-Guo Nicholas, Youngson, Neil A., Maniam, Jayanthi, Wong, Ashley S.A., Selesniemi, Kaisa, Bustamante, Sonia, Li, Catherine, Zhao, Yiqing, Marinova, Maria B., Kim, Lynn-Jee, Lau, Laurin, Wu, Rachael M., Mikolaizak, A. Stefanie, Araki, Toshiyuki, Le Couteur, David G., Turner, Nigel, Morris, Margaret J., Walters, Kirsty A., Goldys, Ewa, O’Neill, Christopher, Gilchrist, Robert B., Sinclair, David A., Homer, Hayden A., Wu, Lindsay E.

“…Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here,…”
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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions by Menk, Ashley V., Scharping, Nicole E., Moreci, Rebecca S., Zeng, Xue, Guy, Cliff, Salvatore, Sonia, Bae, Heekyong, Xie, Jianxin, Young, Howard A., Wendell, Stacy Gelhaus, Delgoffe, Greg M.

“…To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented…”
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Lactate Limits T Cell Proliferation via the NAD(H) Redox State by Quinn, William J., Jiao, Jing, TeSlaa, Tara, Stadanlick, Jason, Wang, Zhonglin, Wang, Liqing, Akimova, Tatiana, Angelin, Alessia, Schäfer, Patrick M., Cully, Michelle D., Perry, Caroline, Kopinski, Piotr K., Guo, Lili, Blair, Ian A., Ghanem, Louis R., Leibowitz, Michael S., Hancock, Wayne W., Moon, Edmund K., Levine, Matthew H., Eruslanov, Evgeniy B., Wallace, Douglas C., Baur, Joseph A., Beier, Ulf H.

“…Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor…”
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Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types by Seiler, Michael, Smith, Peter G., Liu, Yuexin, Reynolds, Sheila, Phillips, Sarah M., Spellman, Paul, Holt, Robert, Schein, Jacqueline E., Sipahimalani, Payal, Thiessen, Nina, Van Den Berg, David J., Weisenberger, Daniel J., Bodenheimer, Tom, Mieczkowski, Piotr A., Veluvolu, Umadevi, Zhou, Wanding, Bellair, Michelle, Gibbs, Richard A., Li, Wei, Zhao, Fengmei, Ding, Li, Mardis, Elaine R., Mallery, David, Paulauskis, Joseph, Corcoran, Niall, Carvalho, Andre L., Vidal, Daniel O., Ittmann, Michael, Lyadov, Vladimir, Shabunin, Alexey, Barrett, Wendi, De Rose, Agostino, Giuliante, Felice, Hagedorn, Curt H., Hu, Hai, Bennett, Joseph, Hibshoosh, Hanina, Potapova, Olga, Voronina, Olga, Berchuck, Andrew, McCall, Shannon, Secord, Angeles, Olson, Jeffrey J., Ramalingam, Suresh, Stoop, Hans, Cuppini, Lucia, Hanh, Phan Thi, Akeredolu, Teniola, Kang, Koo Jeong, Birrer, Michael, Castle, Erik, Kopp, Karla, Roberts, Lewis, Yang, Ju Dong, Angulo Gonzalez, Ana Maria, Bondaruk, Jolanta, Broaddus, Russell, Fujimoto, Junya, Guo, Charles, Ramondetta, Lois, Tsao, Anne, Wistuba, Ignacio, Haydu, Lauren, Scolyer, Richard, Thompson, John, Reuter, Victor, Drwiega, Paul, Metwalli, Adam R., Pinto, Peter A., Vocke, Cathy D., Botnariuc, Natalia, Gorincioi, Ghenadie, Alexopoulou, Iakovina, Tamakawa, Raina, Chevalier, Simone, Schilero, Cathy, Smolenski, Kathy, Borgia, Jeffrey A., Junker, Kerstin, Aziz, Dina, Hilty, Joe, Lehman, Norman L., Tischler, Arthur, Henderson, Joel, Schadendorf, Dirk, Nelson, Mark, Carney, Michael, Hernandez, Brenda, Knutson, Tina, Godwin, Andrew K., Saad, Fred, Valdivieso, Federico, Sankarankuty, Ajith, Catto, James, Creaney, Jenette, Prince, Mark, Fong, Kwun M., Kovatich, Albert J., Aredes, Natália D., Yu, Lihua

“…Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA…”
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BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils by Moorlag, Simone J.C.F.M., Rodriguez-Rosales, Yessica Alina, Gillard, Joshua, Fanucchi, Stephanie, Theunissen, Kate, Novakovic, Boris, de Bont, Cynthia M., Negishi, Yutaka, Fok, Ezio T., Kalafati, Lydia, Verginis, Panayotis, Mourits, Vera P., Koeken, Valerie A.C.M., de Bree, L. Charlotte J., Pruijn, Ger J.M., Fenwick, Craig, van Crevel, Reinout, Joosten, Leo A.B., Joosten, Irma, Koenen, Hans, Mhlanga, Musa M., Diavatopoulos, Dimitri A., Chavakis, Triantafyllos, Netea, Mihai G.

“…The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some heterologous infections, probably via induction of non-specific innate immune…”
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Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms by Peluso, Michael J., Deitchman, Amelia N., Torres, Leonel, Iyer, Nikita S., Munter, Sadie E., Nixon, Christopher C., Donatelli, Joanna, Thanh, Cassandra, Takahashi, Saki, Hakim, Jill, Turcios, Keirstinne, Janson, Owen, Hoh, Rebecca, Tai, Viva, Hernandez, Yanel, Fehrman, Emily A., Spinelli, Matthew A., Gandhi, Monica, Trinh, Lan, Wrin, Terri, Petropoulos, Christos J., Aweeka, Francesca T., Rodriguez-Barraquer, Isabel, Kelly, J. Daniel, Martin, Jeffrey N., Deeks, Steven G., Greenhouse, Bryan, Rutishauser, Rachel L., Henrich, Timothy J.

“…We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses, soluble markers of inflammation, and antibody levels and…”
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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy by Renner, Kathrin, Bruss, Christina, Schnell, Annette, Koehl, Gudrun, Becker, Holger M., Fante, Matthias, Menevse, Ayse-Nur, Kauer, Nathalie, Blazquez, Raquel, Hacker, Lisa, Decking, Sonja-Maria, Bohn, Toszka, Faerber, Stephanie, Evert, Katja, Aigle, Lisa, Amslinger, Sabine, Landa, Maria, Krijgsman, Oscar, Rozeman, Elisa A., Brummer, Christina, Siska, Peter J., Singer, Katrin, Pektor, Stefanie, Miederer, Matthias, Peter, Katrin, Gottfried, Eva, Herr, Wolfgang, Marchiq, Ibtisam, Pouyssegur, Jacques, Roush, William R., Ong, SuFey, Warren, Sarah, Pukrop, Tobias, Beckhove, Philipp, Lang, Sven A., Bopp, Tobias, Blank, Christian U., Cleveland, John L., Oefner, Peter J., Dettmer, Katja, Selby, Mark, Kreutz, Marina

“…Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with…”
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The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade by Schaer, David A., Beckmann, Richard P., Dempsey, Jack A., Huber, Lysiane, Forest, Amelie, Amaladas, Nelusha, Li, Yanxia, Wang, Ying Cindy, Rasmussen, Erik R., Chin, Darin, Capen, Andrew, Carpenito, Carmine, Staschke, Kirk A., Chung, Linda A., Litchfield, Lacey M., Merzoug, Farhana F., Gong, Xueqian, Iversen, Philip W., Buchanan, Sean, de Dios, Alfonso, Novosiadly, Ruslan D., Kalos, Michael

“…Abemaciclib, an inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), has recently been approved for the treatment of hormone receptor-positive breast…”
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METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection by Li, Na, Hui, Hui, Bray, Bill, Gonzalez, Gwendolyn Michelle, Zeller, Mark, Anderson, Kristian G., Knight, Rob, Smith, Davey, Wang, Yinsheng, Carlin, Aaron F., Rana, Tariq M.

“…It is urgent and important to understand the relationship of the widespread severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) with host immune…”
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Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans by Thrupp, Nicola, Sala Frigerio, Carlo, Wolfs, Leen, Skene, Nathan G., Fattorelli, Nicola, Poovathingal, Suresh, Fourne, Yannick, Matthews, Paul M., Theys, Tom, Mancuso, Renzo, de Strooper, Bart, Fiers, Mark

“…Single-nucleus RNA sequencing (snRNA-seq) is used as an alternative to single-cell RNA-seq, as it allows transcriptomic profiling of frozen tissue. However, it…”
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Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes by Miao, Yilong, Cui, Zhaokang, Gao, Qian, Rui, Rong, Xiong, Bo

“…Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined. Here,…”
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