Search Results - "Cell metabolism"

The hallmarks of cancer metabolism: Still emerging by Pavlova, Natalya N., Zhu, Jiajun, Thompson, Craig B.

“…Metabolism of cancer cells is geared toward biomass production and proliferation. Since the metabolic resources within the local tissue are finite, this can…”
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Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes by Zhu, Lihua, She, Zhi-Gang, Cheng, Xu, Qin, Juan-Juan, Zhang, Xiao-Jing, Cai, Jingjing, Lei, Fang, Wang, Haitao, Xie, Jing, Wang, Wenxin, Li, Haomiao, Zhang, Peng, Song, Xiaohui, Chen, Xi, Xiang, Mei, Zhang, Chaozheng, Bai, Liangjie, Xiang, Da, Chen, Ming-Ming, Liu, Yanqiong, Yan, Youqin, Liu, Mingyu, Mao, Weiming, Zou, Jinjing, Liu, Liming, Chen, Guohua, Luo, Pengcheng, Xiao, Bing, Zhang, Changjiang, Zhang, Zixiong, Lu, Zhigang, Wang, Junhai, Lu, Haofeng, Xia, Xigang, Wang, Daihong, Liao, Xiaofeng, Peng, Gang, Ye, Ping, Yang, Jun, Yuan, Yufeng, Huang, Xiaodong, Guo, Jiao, Zhang, Bing-Hong, Li, Hongliang

“…Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and…”
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The Metabolic Underpinnings of Ferroptosis by Zheng, Jiashuo, Conrad, Marcus

“…Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes may trigger a pervasive non-apoptotic form of cell death,…”
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Macrophages and Metabolism in the Tumor Microenvironment by Vitale, Ilio, Manic, Gwenola, Coussens, Lisa M., Kroemer, Guido, Galluzzi, Lorenzo

“…Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50%…”
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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability by Ma, Xingzhe, Xiao, Liuling, Liu, Lintao, Ye, Lingqun, Su, Pan, Bi, Enguang, Wang, Qiang, Yang, Maojie, Qian, Jianfei, Yi, Qing

“…Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found…”
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Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake by Hall, Kevin D., Ayuketah, Alexis, Brychta, Robert, Cai, Hongyi, Cassimatis, Thomas, Chen, Kong Y., Chung, Stephanie T., Costa, Elise, Courville, Amber, Darcey, Valerie, Fletcher, Laura A., Forde, Ciaran G., Gharib, Ahmed M., Guo, Juen, Howard, Rebecca, Joseph, Paule V., McGehee, Suzanne, Ouwerkerk, Ronald, Raisinger, Klaudia, Rozga, Irene, Stagliano, Michael, Walter, Mary, Walter, Peter J., Yang, Shanna, Zhou, Megan

“…We investigated whether ultra-processed foods affect energy intake in 20 weight-stable adults, aged (mean ± SE) 31.2 ± 1.6 years and BMI = 27 ± 1.5 kg/m2…”
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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis by Codo, Ana Campos, Davanzo, Gustavo Gastão, Monteiro, Lauar de Brito, de Souza, Gabriela Fabiano, Muraro, Stéfanie Primon, Virgilio-da-Silva, João Victor, Prodonoff, Juliana Silveira, Carregari, Victor Corasolla, de Biagi Junior, Carlos Alberto Oliveira, Crunfli, Fernanda, Jimenez Restrepo, Jeffersson Leandro, Vendramini, Pedro Henrique, Reis-de-Oliveira, Guilherme, Bispo dos Santos, Karina, Toledo-Teixeira, Daniel A., Parise, Pierina Lorencini, Martini, Matheus Cavalheiro, Marques, Rafael Elias, Carmo, Helison R., Borin, Alexandre, Coimbra, Laís Durço, Boldrini, Vinícius O., Brunetti, Natalia S., Vieira, Andre S., Mansour, Eli, Ulaf, Raisa G., Bernardes, Ana F., Nunes, Thyago A., Ribeiro, Luciana C., Palma, Andre C., Agrela, Marcus V., Moretti, Maria Luiza, Sposito, Andrei C., Pereira, Fabrício Bíscaro, Velloso, Licio Augusto, Vinolo, Marco Aurélio Ramirez, Damasio, André, Proença-Módena, José Luiz, Carvalho, Robson Francisco, Mori, Marcelo A., Martins-de-Souza, Daniel, Nakaya, Helder I., Farias, Alessandro S., Moraes-Vieira, Pedro M.

“…COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the…”
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Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer by Snaebjornsson, Marteinn Thor, Janaki-Raman, Sudha, Schulze, Almut

“…Altered lipid metabolism is among the most prominent metabolic alterations in cancer. Enhanced synthesis or uptake of lipids contributes to rapid cancer cell…”
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Exosomes as mediators of intercellular crosstalk in metabolism by Isaac, Roi, Reis, Felipe Castellani Gomes, Ying, Wei, Olefsky, Jerrold M.

“…Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once…”
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Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease by Mori, Marcelo A, Ludwig, Raissa G, Garcia-Martin, Ruben, Brandão, Bruna B, Kahn, C Ronald

“…miRNAs can be found in serum and other body fluids and serve as biomarkers for disease. More importantly, secreted miRNAs, especially those in extracellular…”
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Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome by Wilkinson, Michael J., Manoogian, Emily N.C., Zadourian, Adena, Lo, Hannah, Fakhouri, Savannah, Shoghi, Azarin, Wang, Xinran, Fleischer, Jason G., Navlakha, Saket, Panda, Satchidananda, Taub, Pam R.

“…In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies…”
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Benefits of Metformin in Attenuating the Hallmarks of Aging by Kulkarni, Ameya S., Gubbi, Sriram, Barzilai, Nir

“…Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin, a biguanide that…”
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AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control by González, Asier, Hall, Michael N., Lin, Sheng-Cai, Hardie, D. Grahame

“…The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are interlinked, opposing signaling pathways involved in sensing availability of…”
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Why does obesity cause diabetes? by Klein, Samuel, Gastaldelli, Amalia, Yki-Järvinen, Hannele, Scherer, Philipp E.

“…The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass…”
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Changing global epidemiology of liver cancer from 2010 to 2019: NASH is the fastest growing cause of liver cancer by Huang, Daniel Q, Singal, Amit G, Kono, Yuko, Tan, Darren J H, El-Serag, Hashem B, Loomba, Rohit

“…Liver cancer epidemiology is changing due to increasing alcohol consumption, rising prevalence of obesity, and advances in hepatitis B virus (HBV) and…”
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Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis by Song, Jin-Wen, Lam, Sin Man, Fan, Xing, Cao, Wen-Jing, Wang, Si-Yu, Tian, He, Chua, Gek Huey, Zhang, Chao, Meng, Fan-Ping, Xu, Zhe, Fu, Jun-Liang, Huang, Lei, Xia, Peng, Yang, Tao, Zhang, Shaohua, Li, Bowen, Jiang, Tian-Jun, Wang, Raoxu, Wang, Zehua, Shi, Ming, Zhang, Ji-Yuan, Wang, Fu-Sheng, Shui, Guanghou

“…The coronavirus disease 2019 (COVID-19) pandemic presents an unprecedented threat to global public health. Herein, we utilized a combination of targeted and…”
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The global burden of metabolic disease: Data from 2000 to 2019 by Chew, Nicholas W.S., Ng, Cheng Han, Tan, Darren Jun Hao, Kong, Gwyneth, Lin, Chaoxing, Chin, Yip Han, Lim, Wen Hui, Huang, Daniel Q., Quek, Jingxuan, Fu, Clarissa Elysia, Xiao, Jieling, Syn, Nicholas, Foo, Roger, Khoo, Chin Meng, Wang, Jiong-Wei, Dimitriadis, Georgios K., Young, Dan Yock, Siddiqui, Mohammad Shadab, Lam, Carolyn S.P., Wang, Yibin, Figtree, Gemma A., Chan, Mark Y., Cummings, David E., Noureddin, Mazen, Wong, Vincent Wai-Sun, Ma, Ronald Ching Wan, Mantzoros, Christos S., Sanyal, Arun, Muthiah, Mark Dhinesh

“…Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019…”
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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity by He, Yao, Fu, Liuhui, Li, Yiping, Wang, Wenyan, Gong, Mingli, Zhang, Jing, Dong, Xin, Huang, Jiaoyan, Wang, Quanbo, Mackay, Charles R., Fu, Yang-Xin, Chen, Yun, Guo, Xiaohuan

“…Recent studies in both mice and humans have suggested that gut microbiota could modulate tumor responsiveness to chemo- or immunotherapies. However, the…”
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Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes by Sutton, Elizabeth F., Beyl, Robbie, Early, Kate S., Cefalu, William T., Ravussin, Eric, Peterson, Courtney M.

“…Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first…”
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Epigenetics in Human Obesity and Type 2 Diabetes by Ling, Charlotte, Rönn, Tina

“…Epigenetic mechanisms control gene activity and the development of an organism. The epigenome includes DNA methylation, histone modifications, and RNA-mediated…”
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