Search Results - "Cell host & microbe"

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure by Giamarellos-Bourboulis, Evangelos J., Netea, Mihai G., Rovina, Nikoletta, Akinosoglou, Karolina, Antoniadou, Anastasia, Antonakos, Nikolaos, Damoraki, Georgia, Gkavogianni, Theologia, Adami, Maria-Evangelia, Katsaounou, Paraskevi, Ntaganou, Maria, Kyriakopoulou, Magdalini, Dimopoulos, George, Koutsodimitropoulos, Ioannis, Velissaris, Dimitrios, Koufargyris, Panagiotis, Karageorgos, Athanassios, Katrini, Konstantina, Lekakis, Vasileios, Lupse, Mihaela, Kotsaki, Antigone, Renieris, George, Theodoulou, Danai, Panou, Vassiliki, Koukaki, Evangelia, Koulouris, Nikolaos, Gogos, Charalambos, Koutsoukou, Antonia

“…Proper management of COVID-19 mandates better understanding of disease pathogenesis. The sudden clinical deterioration 7–8 days after initial symptom onset…”
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Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China by Wu, Aiping, Peng, Yousong, Huang, Baoying, Ding, Xiao, Wang, Xianyue, Niu, Peihua, Meng, Jing, Zhu, Zhaozhong, Zhang, Zheng, Wang, Jiangyuan, Sheng, Jie, Quan, Lijun, Xia, Zanxian, Tan, Wenjie, Cheng, Genhong, Jiang, Taijiao

“…An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome…”
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Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies by Greaney, Allison J., Loes, Andrea N., Crawford, Katharine H.D., Starr, Tyler N., Malone, Keara D., Chu, Helen Y., Bloom, Jesse D.

“…The evolution of SARS-CoV-2 could impair recognition of the virus by human antibody-mediated immunity. To facilitate prospective surveillance for such…”
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Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition by Greaney, Allison J., Starr, Tyler N., Gilchuk, Pavlo, Zost, Seth J., Binshtein, Elad, Loes, Andrea N., Hilton, Sarah K., Huddleston, John, Eguia, Rachel, Crawford, Katharine H.D., Dingens, Adam S., Nargi, Rachel S., Sutton, Rachel E., Suryadevara, Naveenchandra, Rothlauf, Paul W., Liu, Zhuoming, Whelan, Sean P.J., Carnahan, Robert H., Crowe, James E., Bloom, Jesse D.

“…Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing…”
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Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization by Liu, Zhuoming, VanBlargan, Laura A., Bloyet, Louis-Marie, Rothlauf, Paul W., Chen, Rita E., Stumpf, Spencer, Zhao, Haiyan, Errico, John M., Theel, Elitza S., Liebeskind, Mariel J., Alford, Brynn, Buchser, William J., Ellebedy, Ali H., Fremont, Daved H., Diamond, Michael S., Whelan, Sean P.J.

“…Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19 vaccines and have received emergency use authorization as therapeutics…”
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Infection and Rapid Transmission of SARS-CoV-2 in Ferrets by Kim, Young-Il, Kim, Seong-Gyu, Kim, Se-Mi, Kim, Eun-Ha, Park, Su-Jin, Yu, Kwang-Min, Chang, Jae-Hyung, Kim, Eun Ji, Lee, Seunghun, Casel, Mark Anthony B., Um, Jihye, Song, Min-Suk, Jeong, Hye Won, Lai, Van Dam, Kim, Yeonjae, Chin, Bum Sik, Park, Jun-Sun, Chung, Ki-Hyun, Foo, Suan-Sin, Poo, Haryoung, Mo, In-Pil, Lee, Ok-Jun, Webby, Richard J., Jung, Jae U., Choi, Young Ki

“…The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China and rapidly spread…”
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A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2 by Grifoni, Alba, Sidney, John, Zhang, Yun, Scheuermann, Richard H., Peters, Bjoern, Sette, Alessandro

“…Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools…”
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Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19 by Park, Annsea, Iwasaki, Akiko

“…Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral…”
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Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization by Wang, Pengfei, Casner, Ryan G., Nair, Manoj S., Wang, Maple, Yu, Jian, Cerutti, Gabriele, Liu, Lihong, Kwong, Peter D., Huang, Yaoxing, Shapiro, Lawrence, Ho, David D.

“…The emergence of SARS-CoV-2 variants has raised concerns about altered sensitivity to antibody-mediated immunity. The relative resistance of SARS-CoV-2…”
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The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease by Makki, Kassem, Deehan, Edward C., Walter, Jens, Bäckhed, Fredrik

“…Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also…”
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Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease by Agus, Allison, Planchais, Julien, Sokol, Harry

“…The gut microbiota is a crucial actor in human physiology. Many of these effects are mediated by metabolites that are either produced by the microbes or…”
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A Mouse Model of SARS-CoV-2 Infection and Pathogenesis by Sun, Shi-Hui, Chen, Qi, Gu, Hong-Jing, Yang, Guan, Wang, Yan-Xiao, Huang, Xing-Yao, Liu, Su-Su, Zhang, Na-Na, Li, Xiao-Feng, Xiong, Rui, Guo, Yan, Deng, Yong-Qiang, Huang, Wei-Jin, Liu, Quan, Liu, Quan-Ming, Shen, Yue-Lei, Zhou, Yong, Yang, Xiao, Zhao, Tong-Yan, Fan, Chang-Fa, Zhou, Yu-Sen, Qin, Cheng-Feng, Wang, You-Chun

“…Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread throughout the world, resulting in a global public health emergency. The…”
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Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis by Cai, Jie, Sun, Lulu, Gonzalez, Frank J

“…Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal diseases that threaten the health of an increasing number of…”
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Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite by Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence

“…Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal…”
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An Infectious cDNA Clone of SARS-CoV-2 by Xie, Xuping, Muruato, Antonio, Lokugamage, Kumari G., Narayanan, Krishna, Zhang, Xianwen, Zou, Jing, Liu, Jianying, Schindewolf, Craig, Bopp, Nathen E., Aguilar, Patricia V., Plante, Kenneth S., Weaver, Scott C., Makino, Shinji, LeDuc, James W., Menachery, Vineet D., Shi, Pei-Yong

“…The ongoing pandemic of COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), underscores the urgency to develop experimental…”
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Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation by Sinha, Sidhartha R., Haileselassie, Yeneneh, Nguyen, Linh P., Tropini, Carolina, Wang, Min, Becker, Laren S., Sim, Davis, Jarr, Karolin, Spear, Estelle T., Singh, Gulshan, Namkoong, Hong, Bittinger, Kyle, Fischbach, Michael A., Sonnenburg, Justin L., Habtezion, Aida

“…Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant on biosynthetic capabilities possessed by few microbes. To evaluate…”
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Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria by Kortright, Kaitlyn E., Chan, Benjamin K., Koff, Jonathan L., Turner, Paul E.

“…Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in Western medicine. This stems from the rise in frequency of…”
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The Gut Virome Database Reveals Age-Dependent Patterns of Virome Diversity in the Human Gut by Gregory, Ann C., Zablocki, Olivier, Zayed, Ahmed A., Howell, Allison, Bolduc, Benjamin, Sullivan, Matthew B.

“…The gut microbiome profoundly affects human health and disease, and their infecting viruses are likely as important, but often missed because of reference…”
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Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome by Ferretti, Pamela, Pasolli, Edoardo, Tett, Adrian, Asnicar, Francesco, Gorfer, Valentina, Fedi, Sabina, Armanini, Federica, Truong, Duy Tin, Manara, Serena, Zolfo, Moreno, Beghini, Francesco, Bertorelli, Roberto, De Sanctis, Veronica, Bariletti, Ilaria, Canto, Rosarita, Clementi, Rosanna, Cologna, Marina, Crifò, Tiziana, Cusumano, Giuseppina, Gottardi, Stefania, Innamorati, Claudia, Masè, Caterina, Postai, Daniela, Savoi, Daniela, Duranti, Sabrina, Lugli, Gabriele Andrea, Mancabelli, Leonardo, Turroni, Francesca, Ferrario, Chiara, Milani, Christian, Mangifesta, Marta, Anzalone, Rosaria, Viappiani, Alice, Yassour, Moran, Vlamakis, Hera, Xavier, Ramnik, Collado, Carmen Maria, Koren, Omry, Tateo, Saverio, Soffiati, Massimo, Pedrotti, Anna, Ventura, Marco, Huttenhower, Curtis, Bork, Peer, Segata, Nicola

“…The acquisition and development of the infant microbiome are key to establishing a healthy host-microbiome symbiosis. The maternal microbial reservoir is…”
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Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota by Teng, Yun, Ren, Yi, Sayed, Mohammed, Hu, Xin, Lei, Chao, Kumar, Anil, Hutchins, Elizabeth, Mu, Jingyao, Deng, Zhongbin, Luo, Chao, Sundaram, Kumaran, Sriwastva, Mukesh K., Zhang, Lifeng, Hsieh, Michael, Reiman, Rebecca, Haribabu, Bodduluri, Yan, Jun, Jala, Venkatakrishna Rao, Miller, Donald M., Van Keuren-Jensen, Kendall, Merchant, Michael L., McClain, Craig J., Park, Juw Won, Egilmez, Nejat K., Zhang, Huang-Ge

“…The gut microbiota can be altered by dietary interventions to prevent and treat various diseases. However, the mechanisms by which food products modulate…”
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