Search Results - "Cell cycle (Georgetown, Tex.)"

Partial inhibition of Cdk1 in G2 phase overrides the SAC and decouples mitotic events by McCloy, Rachael A, Rogers, Samuel, Caldon, C Elizabeth, Lorca, Thierry, Castro, Anna, Burgess, Andrew

“…Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1). In this study we utilized low…”
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Role of the c subunit of the F O ATP synthase in mitochondrial permeability transition by Bonora, Massimo, Bononi, Angela, De Marchi, Elena, Giorgi, Carlotta, Lebiedzinska, Magdalena, Marchi, Saverio, Patergnani, Simone, Rimessi, Alessandro, Suski, Jan M., Wojtala, Aleksandra, Wieckowski, Mariusz R., Kroemer, Guido, Galluzzi, Lorenzo, Pinton, Paolo

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Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition by Bonora, Massimo, Bononi, Angela, De Marchi, Elena, Giorgi, Carlotta, Lebiedzinska, Magdalena, Marchi, Saverio, Patergnani, Simone, Rimessi, Alessandro, Suski, Jan M., Wojtala, Aleksandra, Wieckowski, Mariusz R., Kroemer, Guido, Galluzzi, Lorenzo, Pinton, Paolo

“…The term "mitochondrial permeability transition" (MPT) refers to an abrupt increase in the permeability of the inner mitochondrial membrane to low molecular…”
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LncRNA CASC11 promoted gastric cancer cell proliferation, migration and invasion in vitro by regulating cell cycle pathway by Zhang, Li, Kang, Wenquan, Lu, Xiaolan, Ma, Shiyang, Dong, Lei, Zou, Baicang

“…In this study, we aimed to investigate the effects of lncRNA CASC11 on gastric cancer (GC) cell progression through regulating miR-340-5p and cell cycle…”
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Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer by Ji, Runbi, Zhang, Bin, Zhang, Xu, Xue, Jianguo, Yuan, Xiao, Yan, Yongmin, Wang, Mei, Zhu, Wei, Qian, Hui, Xu, Wenrong

“…Mesenchymal stem cells (MSCs) play an important role in chemoresistance. Exosomes have been reported to modify cellular phenotype and function by mediating…”
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Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism by Bonuccelli, Gloria, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Pavlides, Stephanos, Pestell, Richard G., Chiavarina, Barbara, Frank, Philippe G., Flomenberg, Neal, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.

“…Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic…”
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Exosomes-carried microRNA-26b-5p regulates microglia M1 polarization after cerebral ischemia/reperfusion by Li, Guangying, Xiao, Longhai, Qin, Hao, Zhuang, Qiang, Zhang, Weiwei, Liu, Long, Di, Chao, Zhang, Yabo

“…Exosome and microRNAs (miRs) are implicated in ischemia/reperfusion (I/R) process. In this study, I/R mouse model was established, and exosomes derived from…”
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γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization by Löbrich, Markus, Shibata, Atsushi, Beucher, Andrea, Fisher, Anna, Ensminger, Michael, Goodarzi, Aaron A., Barton, Olivia, Jeggo, Penny A.

“…DNA double-strand breaks (DSBs) represent an important radiation-induced lesion and impaired DSB repair provides the best available correlation with…”
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Accurate delineation of cell cycle phase transitions in living cells with PIP-FUCCI by Grant, Gavin D., Kedziora, Katarzyna M., Limas, Juanita C., Cook, Jeanette Gowen, Purvis, Jeremy E.

“…Cell cycle phase transitions are tightly orchestrated to ensure efficient cell cycle progression and genome stability. Interrogating these transitions is…”
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Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenase-1-dependent pathway by Ju, Songwen, Ge, Yan, Li, Ping, Tian, Xinxin, Wang, Haiyan, Zheng, Xiaocui, Ju, Songguang

“…Inflammatory bowel disease (IBD) results from a chronic intestinal inflammation and tissue destruction via an aberrant immune-driven inflammatory response…”
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Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts by Whitaker-Menezes, Diana, Martinez-Outschoorn, Ubaldo E., Lin, Zhao, Ertel, Adam, Flomenberg, Neal, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pavlides, Stephanos, Gandara, Ricardo, Pestell, Richard G., Sotgia, Federica, Philp, Nancy J., Lisanti, Michael P

“…Recently, we proposed a new mechanism for understanding the Warburg effect in cancer metabolism. In this new paradigm, cancer-associated fibroblasts undergo…”
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Large oncosomes mediate intercellular transfer of functional microRNA by Morello, Matteo, Minciacchi, Valentina, de Candia, Paola, Yang, Julie, Posadas, Edwin, Kim, Hyung, Griffiths, Duncan, Bhowmick, Neil, Chung, Leland, Gandellini, Paolo, Freeman, Michael, Demichelis, Francesca, DiVizio, Dolores

“…Prostate cancer cells release atypically large extracellular vesicles (EVs), termed large oncosomes, which may play a role in the tumor microenvironment by…”
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Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells by Martinez-Outschoorn, Ubaldo E., Balliet, Renee M., Rivadeneira, Dayana, Chiavarina, Barbara, Pavlides, Stephanos, Wang, Chenguang, Whitaker-Menezes, Diana, Daumer, Kristin, Lin, Zhao, Witkiewicz, Agnieszka, Flomenberg, Neal, Howell, Anthony, Pestell, Richard, Knudsen, Erik, Sotgia, Federica, Lisanti, Michael P.

“…Loss of stromal fibroblast caveolin-1 (Cav-1) is a powerful single independent predictor of poor prognosis in human breast cancer patients, and is associated…”
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Long non-coding RNA CCAT1 promotes multiple myeloma progression by acting as a molecular sponge of miR-181a-5p to modulate HOXA1 expression by Chen, Li, Hu, Ning, Wang, Chao, Zhao, Hongmian, Gu, Yueli

“…Multiple myeloma (MM) is the second most common hematological cancer all over the world. Long non-coding RNA (lncRNA) colon cancer associated transcript-1…”
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Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19 by Valipour, Mehdi, Zarghi, Afshin, Ebrahimzadeh, Mohammad Ali, Irannejad, Hamid

“…Multifunctional nature of phytochemicals and their chemical diversity has attracted attention to develop leads originated from nature to fight COVID-19…”
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MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis by Liu, Yubao, Lin, Lupan, Zou, Rui, Wen, Chuanyang, Wang, Zhen, Lin, Fuqing

“…Background: Exosomes secreted by human mesenchymal stem cells (hMSCs) have been shown to promote cartilage regeneration. This study aimed to explore whether…”
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Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer by Mu, Xianmin, Shi, Wei, Xu, Yue, Xu, Che, Zhao, Ting, Geng, Biao, Yang, Jing, Pan, Jinshun, Hu, Shi, Zhang, Chen, Zhang, Juan, Wang, Chao, Shen, Jiajia, Che, Yin, Liu, Zheng, Lv, Yuanfang, Wen, Hao, You, Qiang

“…Tumor-associated macrophages (TAM) are prominent components of tumor microenvironment (TME) and capable of promoting cancer progression. However, the…”
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The double dealing of cyclin D1 by Tchakarska, Guergana, Sola, Brigitte

“…The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts…”
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Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer by Xie, Shuping, Ge, Quanxing, Wang, Xueyan, Sun, Xinfang, Kang, Yuhua

“…The incidence and mortality rate of colorectal cancer (CRC) have been significantly increasing. However, mechanisms involved in CRC progression are still…”
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TGF-β secreted by tumor-associated macrophages promotes proliferation and invasion of colorectal cancer via miR-34a-VEGF axis by Zhang, Danhua, Qiu, Xinguang, Li, Jianhua, Zheng, Shouhua, Li, Liwen, Zhao, Hongchao

“…Tumor-associated macrophages (TAMs) were reported to be involved in colorectal cancer (CRC) progression. However, its biological role and underlying mechanism…”
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