Search Results - "Cell communication and signaling"

The exosome journey: from biogenesis to uptake and intracellular signalling by Gurung, Sonam, Perocheau, Dany, Touramanidou, Loukia, Baruteau, Julien

“…The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications…”
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Tumor microenvironment complexity and therapeutic implications at a glance by Baghban, Roghayyeh, Roshangar, Leila, Jahanban-Esfahlan, Rana, Seidi, Khaled, Ebrahimi-Kalan, Abbas, Jaymand, Mehdi, Kolahian, Saeed, Javaheri, Tahereh, Zare, Peyman

“…The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components…”
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A review on exosomes application in clinical trials: perspective, questions, and challenges by Rezaie, Jafar, Feghhi, Maryam, Etemadi, Tahereh

“…Abstract Background Exosomes are progressively known as significant mediators of cell-to-cell communication. They convey active biomolecules to target cells…”
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Tumor immunotherapies by immune checkpoint inhibitors (ICIs); the pros and cons by Naimi, Adel, Mohammed, Rebar N, Raji, Ahmed, Chupradit, Supat, Yumashev, Alexei Valerievich, Suksatan, Wanich, Shalaby, Mohammed Nader, Thangavelu, Lakshmi, Kamrava, Siavash, Shomali, Navid, Sohrabi, Armin D, Adili, Ali, Noroozi-Aghideh, Ali, Razeghian, Ehsan

“…The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint (IC) proteins, which act as a potent suppressor of the immune system by a…”
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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells by Seif, Farhad, Khoshmirsafa, Majid, Aazami, Hossein, Mohsenzadegan, Monireh, Sedighi, Gholamreza, Bahar, Mohammadali

“…The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially…”
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Types of nuclear localization signals and mechanisms of protein import into the nucleus by Lu, Juane, Wu, Tao, Zhang, Biao, Liu, Suke, Song, Wenjun, Qiao, Jianjun, Ruan, Haihua

“…Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into…”
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Role of STAT3 signaling pathway in breast cancer by Ma, Jia-Hui, Qin, Li, Li, Xia

“…Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to…”
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Distinct functions of AKT isoforms in breast cancer: a comprehensive review by Hinz, Nico, Jücker, Manfred

“…AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. tumor growth,…”
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Drug resistance and Cancer stem cells by Li, Yuan, Wang, Zhenning, Ajani, Jaffer A, Song, Shumei

“…Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds,…”
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CCL2/CCR2 signaling in cancer pathogenesis by Hao, Qiongyu, Vadgama, Jaydutt V, Wang, Piwen

“…Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression…”
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Regulation of the master regulator FOXM1 in cancer by Liao, Guo-Bin, Li, Xin-Zhe, Zeng, Shuo, Liu, Cheng, Yang, Shi-Ming, Yang, Li, Hu, Chang-Jiang, Bai, Jian-Ying

“…FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It…”
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A highlight on Sonic hedgehog pathway by Carballo, Gabriela Basile, Honorato, Jéssica Ribeiro, de Lopes, Giselle Pinto Farias, Spohr, Tania Cristina Leite de Sampaio E

“…Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog…”
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The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma by Tang, Bufu, Zhu, Jinyu, Li, Jie, Fan, Kai, Gao, Yang, Cheng, Shimiao, Kong, Chunli, Zheng, Liyun, Wu, Fazong, Weng, Qiaoyou, Lu, Chenying, Ji, Jiansong

“…In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the…”
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How vascular smooth muscle cell phenotype switching contributes to vascular disease by Cao, Genmao, Xuan, Xuezhen, Hu, Jie, Zhang, Ruijing, Jin, Haijiang, Dong, Honglin

“…Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury…”
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Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells by Zegeye, Mulugeta M, Lindkvist, Madelene, Fälker, Knut, Kumawat, Ashok K, Paramel, Geena, Grenegård, Magnus, Sirsjö, Allan, Ljungberg, Liza U

“…IL-6 classic signaling is linked to anti-inflammatory functions while the trans-signaling is associated with pro-inflammatory responses. Classic signaling is…”
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Phase separation in biology; functional organization of a higher order by Mitrea, Diana M, Kriwacki, Richard W

“…Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded compartments and, within these, some are further organized into…”
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Short-chain fatty acids in diseases by Zhang, Dan, Jian, Yong-Ping, Zhang, Yu-Ning, Li, Yao, Gu, Li-Ting, Sun, Hui-Hui, Liu, Ming-Di, Zhou, Hong-Lan, Wang, Yi-Shu, Xu, Zhi-Xiang

“…Abstract Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation of dietary fibre in the gastrointestinal tract. The…”
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Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges by Nemati, Mohadeseh, Singh, Bipin, Mir, Rakeeb Ahmad, Nemati, Mahdieh, Babaei, Azadeh, Ahmadi, Mahdi, Rasmi, Yousef, Golezani, Afsaneh Gholinejad, Rezaie, Jafar

“…Many eukaryote cells produce membrane-enclosed extracellular vesicles (EVs) to establish cell-to-cell communication. Plant-derived EVs (P-EVs) contain…”
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Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways by Yang, Huahong, Lv, Hongming, Li, Haijun, Ci, Xinxin, Peng, Liping

“…Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2…”
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The regulatory roles of neutrophils in adaptive immunity by Li, Yang, Wang, Wei, Yang, Fan, Xu, Yanan, Feng, Chang, Zhao, Yong

“…Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly…”
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