Search Results - "Cell & bioscience"

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges by Zou, Zhilin, Tao, Tao, Li, Hongmei, Zhu, Xiao

“…Mammalian target of rapamycin (mTOR) regulates cell proliferation, autophagy, and apoptosis by participating in multiple signaling pathways in the body…”
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Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours by Xu, Fei, Na, Lixin, Li, Yanfei, Chen, Linjun

“…The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation,…”
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SARS-CoV-2 and COVID-19: The most important research questions by Yuen, Kit-San, Ye, Zi-Wei, Fung, Sin-Yee, Chan, Chi-Ping, Jin, Dong-Yan

“…Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we…”
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Signaling pathways involved in colorectal cancer progression by Koveitypour, Zahra, Panahi, Farnoush, Vakilian, Mehrdad, Peymani, Maryam, Seyed Forootan, Farzad, Nasr Esfahani, Mohammad Hossein, Ghaedi, Kamran

“…Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development…”
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PKM2, function and expression and regulation by Zhang, Ze, Deng, Xinyue, Liu, Yuanda, Liu, Yahui, Sun, Liankun, Chen, Fangfang

“…Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is…”
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SARS-CoV-2: from its discovery to genome structure, transcription, and replication by Brant, Ayslan Castro, Tian, Wei, Majerciak, Vladimir, Yang, Wei, Zheng, Zhi-Ming

“…SARS-CoV-2 is an extremely contagious respiratory virus causing adult atypical pneumonia COVID-19 with severe acute respiratory syndrome (SARS). SARS-CoV-2 has…”
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Apigenin in cancer therapy: anti-cancer effects and mechanisms of action by Yan, Xiaohui, Qi, Miao, Li, Pengfei, Zhan, Yihong, Shao, Huanjie

“…Apigenin is a common dietary flavonoid that is abundantly present in many fruits, vegetables and Chinese medicinal herbs and serves multiple physiological…”
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Quercetin and cancer: new insights into its therapeutic effects on ovarian cancer cells by Vafadar, Asma, Shabaninejad, Zahra, Movahedpour, Ahmad, Fallahi, Farzaneh, Taghavipour, Mona, Ghasemi, Younes, Akbari, Maryam, Shafiee, Alimohammad, Hajighadimi, Sarah, Moradizarmehri, Sanaz, Razi, Ebrahim, Savardashtaki, Amir, Mirzaei, Hamed

“…Ovarian cancer is known as a serious malignancy that affects women's reproductive tract and can considerably threat their health. A wide range of molecular…”
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Three-dimensional in vitro culture models in oncology research by Jubelin, Camille, Muéoz-Garcia, Javier, Griscom, Laurent, Cochonneau, Denis, Ollivier, Emilie, Heymann, Marie-Françoise, Vallette, François M, Oliver, Lisa, Heymann, Dominique

“…Abstract Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra- and inter-heterogeneity of malignant tumors make it…”
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The single-cell sequencing: new developments and medical applications by Tang, Xiaoning, Huang, Yongmei, Lei, Jinli, Luo, Hui, Zhu, Xiao

“…Single-cell sequencing technologies can be used to detect the genome, transcriptome and other multi-omics of single cells. They can show the differences and…”
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Extracellular matrix: an important regulator of cell functions and skeletal muscle development by Zhang, Weiya, Liu, Yuan, Zhang, Hong

“…Extracellular matrix (ECM) is a kind of connective tissue in the cell microenvironment, which is of great significance to tissue development. ECM in muscle…”
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Treatment of spinal cord injury with mesenchymal stem cells by Liau, Ling Ling, Looi, Qi Hao, Chia, Wui Chuen, Subramaniam, Thayaalini, Ng, Min Hwei, Law, Jia Xian

“…Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients…”
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Structure, kinetic properties and biological function of mechanosensitive Piezo channels by Fang, Xiang-Zhi, Zhou, Ting, Xu, Ji-Qian, Wang, Ya-Xin, Sun, Miao-Miao, He, Ya-Jun, Pan, Shang-Wen, Xiong, Wei, Peng, Zhe-Kang, Gao, Xue-Hui, Shang, You

“…Mechanotransduction couples mechanical stimulation with ion flux, which is critical for normal biological processes involved in neuronal cell development, pain…”
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Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics by He, Mingqian, Shi, Bingyin

“…Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to…”
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Targeting tumor-associated macrophages for cancer treatment by Li, Mengjun, He, Linye, Zhu, Jing, Zhang, Peng, Liang, Shufang

“…Tumor-associated macrophages (TAMs) are abundant, nearly accounting for 30-50% of stromal cells in the tumor microenvironment. TAMs exhibit an…”
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BIRC3 and BIRC5: multi-faceted inhibitors in cancer by Frazzi, Raffaele

“…The evasion from apoptosis is a common strategy adopted by most tumors, and inhibitors of apoptosis proteins (IAPs) are among the most studied molecular and…”
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Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls by Heidarzadeh, Morteza, Gürsoy-üzdemir, Yasemin, Kaya, Mehmet, Eslami Abriz, Aysan, Zarebkohan, Amir, Rahbarghazi, Reza, Sokullu, Emel

“…Abstract Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases…”
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Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer by Xia, MengFang, Zhang, YaZhuo, Jin, Ke, Lu, ZiTong, Zeng, Zhaoyang, Xiong, Wei

“…Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic…”
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Allogeneic vs. autologous mesenchymal stem/stromal cells in their medication practice by Li, Chenghai, Zhao, Hua, Cheng, Linna, Wang, Bin

“…Abstract Mesenchymal stem/stromal cell (MSC)-based therapeutics is already available for treatment of a range of diseases or medical conditions. Autologous or…”
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Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases by Liu, Zonghan, Sun, Yi, Qi, Zhengtang, Cao, Lu, Ding, Shuzhe

“…Mitochondria play a pivotal role in energy generation and cellular physiological processes. These organelles are highly dynamic, constantly changing their…”
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