Search Results - "Cell"

Hallmarks of aging: An expanding universe by López-Otín, Carlos, Blasco, Maria A., Partridge, Linda, Serrano, Manuel, Kroemer, Guido

“…Aging is driven by hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally…”
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Integrated analysis of multimodal single-cell data by Hao, Yuhan, Hao, Stephanie, Andersen-Nissen, Erica, Mauck, William M., Zheng, Shiwei, Butler, Andrew, Lee, Maddie J., Wilk, Aaron J., Darby, Charlotte, Zager, Michael, Hoffman, Paul, Stoeckius, Marlon, Papalexi, Efthymia, Mimitou, Eleni P., Jain, Jaison, Srivastava, Avi, Stuart, Tim, Fleming, Lamar M., Yeung, Bertrand, Rogers, Angela J., McElrath, Juliana M., Blish, Catherine A., Gottardo, Raphael, Smibert, Peter, Satija, Rahul

“…The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can…”
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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications by Stockwell, Brent R

“…Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified as a distinct phenomenon and named a decade ago. Ferroptosis has…”
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor by Hoffmann, Markus, Kleine-Weber, Hannah, Schroeder, Simon, Krüger, Nadine, Herrler, Tanja, Erichsen, Sandra, Schiergens, Tobias S., Herrler, Georg, Wu, Nai-Huei, Nitsche, Andreas, Müller, Marcel A., Drosten, Christian, Pöhlmann, Stefan

“…The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health…”
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Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus by Korber, Bette, Fischer, Will M., Gnanakaran, Sandrasegaram, Yoon, Hyejin, Theiler, James, Abfalterer, Werner, Hengartner, Nick, Giorgi, Elena E., Bhattacharya, Tanmoy, Foley, Brian, Hastie, Kathryn M., Parker, Matthew D., Partridge, David G., Evans, Cariad M., Freeman, Timothy M., de Silva, Thushan I., Angyal, Adrienne, Brown, Rebecca L., Carrilero, Laura, Green, Luke R., Groves, Danielle C., Johnson, Katie J., Keeley, Alexander J., Lindsey, Benjamin B., Parsons, Paul J., Raza, Mohammad, Rowland-Jones, Sarah, Smith, Nikki, Tucker, Rachel M., Wang, Dennis, Wyles, Matthew D., McDanal, Charlene, Perez, Lautaro G., Tang, Haili, Moon-Walker, Alex, Whelan, Sean P., LaBranche, Celia C., Saphire, Erica O., Montefiori, David C.

“…A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become the most prevalent form in the global pandemic. Dynamic tracking of variant…”
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Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein by Walls, Alexandra C., Park, Young-Jun, Tortorici, M. Alejandra, Wall, Abigail, McGuire, Andrew T., Veesler, David

“…The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main…”
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Alarming antibody evasion properties of rising SARS-CoV-2 BQ and XBB subvariants by Wang, Qian, Iketani, Sho, Li, Zhiteng, Liu, Liyuan, Guo, Yicheng, Huang, Yiming, Bowen, Anthony D., Liu, Michael, Wang, Maple, Yu, Jian, Valdez, Riccardo, Lauring, Adam S., Sheng, Zizhang, Wang, Harris H., Gordon, Aubree, Liu, Lihong, Ho, David D.

“…The BQ and XBB subvariants of SARS-CoV-2 Omicron are now rapidly expanding, possibly due to altered antibody evasion properties deriving from their additional…”
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Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals by Grifoni, Alba, Weiskopf, Daniela, Ramirez, Sydney I., Mateus, Jose, Dan, Jennifer M., Moderbacher, Carolyn Rydyznski, Rawlings, Stephen A., Sutherland, Aaron, Premkumar, Lakshmanane, Jadi, Ramesh S., Marrama, Daniel, de Silva, Aravinda M., Frazier, April, Carlin, Aaron F., Greenbaum, Jason A., Peters, Bjoern, Krammer, Florian, Smith, Davey M., Crotty, Shane, Sette, Alessandro

“…Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and…”
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 by Blanco-Melo, Daniel, Nilsson-Payant, Benjamin E., Liu, Wen-Chun, Uhl, Skyler, Hoagland, Daisy, Møller, Rasmus, Jordan, Tristan X., Oishi, Kohei, Panis, Maryline, Sachs, David, Wang, Taia T., Schwartz, Robert E., Lim, Jean K., Albrecht, Randy A., tenOever, Benjamin R.

“…Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information…”
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Adaptive immunity to SARS-CoV-2 and COVID-19 by Sette, Alessandro, Crotty, Shane

“…The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the…”
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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses by Wang, Beibei, Skelly, Donal, Pan, Daniel, Omo-Dare, Nicola, Koeckerling, David, Jenkin, Daniel, Fernandes da Costa, Cristiano, Malik, Tariq, Baillie, J. Kenneth, Klenerman, Paul, Pollard, Andrew J., Conlon, Christopher, Jeffery, Katie, Stafford, Lizzie, Chand, Meera, Green, Christoper A., Harrison, Ewen M., Wai Ho, Antonia Ying, Palmarini, Massimo, Price, Nicholas, Robertson, David L., Sigfrid, Louise, Sriskandan, Shiranee, Stuart, David, Swann, Olivia V., Tedder, Richard S., Turtle, Lance CW, Zambon, Maria, Pius, Riinu, Knight, Stephen R., Harrison, Janet, Jackson, Clare, Gamble, Carrol, Plotkin, Daniel, Lee, James, Wham, Murray, Shaw, Victoria, McDonald, Sarah E., Armstrong, Jane A., Ashworth, Milton, Barlow, Samantha L., Bullock, Katie, Davis, Christopher, Dunn, Chris, King, Katharine, Kiy, Robyn T., Lant, Suzannah, Latawiec, Diane, Mancini, Maria, Metelmann, Soeren, Penrice-Randal, Rebekah, Pilgrim, Jack, van Tonder, Libby, Murphy, Lee, Morrice, Kirstie, Gilchrist, Tammy, Aldera, Erin L., Barnass, Stella, Bernatoniene, Jolanta, Bothma, Pieter, Brittain-Long, Robin, Caruth, Vikki, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Dushianthan, Ahilanadan, Evans, Cariad, Harvey, Daniel, Hawcutt, Daniel B., Hodgson, Luke, Hormis, Anil, Kerrison, Caroline, Larkin, Susan, Little, Jeff, Meda, Manjula, Moon, James, Mortimore, Katherine, Murphy, Michael, O’Shea, Matthew K., Otahal, Igor, Panchatsharam, Selva, Patel, Brij, Pepperell, Justin, Peters, Mark, Price, David, Reschreiter, Henrik, Ruge, Bobby, Saluja, Taranprit, Sizer, Jeremy, Shankar-Hari, Manu, Snelson, Catherine, Staines, Nikki, Twagira, Mary, Vincent-Smith, Lisa, Visuvanathan, Shico, Welters, Ingeborg, Wolverson, Adam, Yates, Bryan, Fry, Elizabeth E., Ren, Jingshan

“…On 24th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B.1.1.529 was announced, containing far more mutations in Spike (S) than…”
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mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant by Garcia-Beltran, Wilfredo F., St. Denis, Kerri J., Hoelzemer, Angelique, Lam, Evan C., Nitido, Adam D., Sheehan, Maegan L., Berrios, Cristhian, Ofoman, Onosereme, Chang, Christina C., Hauser, Blake M., Feldman, Jared, Roederer, Alex L., Gregory, David J., Poznansky, Mark C., Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Recent surveillance has revealed the emergence of the SARS-CoV-2 Omicron variant (BA.1/B.1.1.529) harboring up to 36 mutations in spike protein, the target of…”
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Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity by Rydyznski Moderbacher, Carolyn, Ramirez, Sydney I., Dan, Jennifer M., Grifoni, Alba, Hastie, Kathryn M., Weiskopf, Daniela, Belanger, Simon, Abbott, Robert K., Kim, Christina, Choi, Jinyong, Kato, Yu, Crotty, Eleanor G., Kim, Cheryl, Rawlings, Stephen A., Mateus, Jose, Tse, Long Ping Victor, Frazier, April, Baric, Ralph, Peters, Bjoern, Greenbaum, Jason, Ollmann Saphire, Erica, Smith, Davey M., Sette, Alessandro, Crotty, Shane

“…Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination…”
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Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 by Wang, Qihui, Zhang, Yanfang, Wu, Lili, Niu, Sheng, Song, Chunli, Zhang, Zengyuan, Lu, Guangwen, Qiao, Chengpeng, Hu, Yu, Yuen, Kwok-Yung, Wang, Qisheng, Zhou, Huan, Yan, Jinghua, Qi, Jianxun

“…The recent emergence of a novel coronavirus (SARS-CoV-2) in China has caused significant public health concerns. Recently, ACE2 was reported as an entry…”
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Hallmarks of response, resistance, and toxicity to immune checkpoint blockade by Morad, Golnaz, Helmink, Beth A., Sharma, Padmanee, Wargo, Jennifer A.

“…Unprecedented advances have been made in cancer treatment with the use of immune checkpoint blockade (ICB). However, responses are limited to a subset of…”
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Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity by Garcia-Beltran, Wilfredo F., Lam, Evan C., St. Denis, Kerri, Nitido, Adam D., Garcia, Zeidy H., Hauser, Blake M., Feldman, Jared, Pavlovic, Maia N., Gregory, David J., Poznansky, Mark C., Sigal, Alex, Schmidt, Aaron G., Iafrate, A. John, Naranbhai, Vivek, Balazs, Alejandro B.

“…Vaccination elicits immune responses capable of potently neutralizing SARS-CoV-2. However, ongoing surveillance has revealed the emergence of variants…”
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Multiple early factors anticipate post-acute COVID-19 sequelae by Su, Yapeng, Yuan, Dan, Chen, Daniel G., Ng, Rachel H., Wang, Kai, Choi, Jongchan, Li, Sarah, Hong, Sunga, Zhang, Rongyu, Xie, Jingyi, Kornilov, Sergey A., Scherler, Kelsey, Pavlovitch-Bedzyk, Ana Jimena, Dong, Shen, Lausted, Christopher, Lee, Inyoul, Fallen, Shannon, Dai, Chengzhen L., Baloni, Priyanka, Smith, Brett, Duvvuri, Venkata R., Anderson, Kristin G., Li, Jing, Yang, Fan, Duncombe, Caroline J., McCulloch, Denise J., Rostomily, Clifford, Troisch, Pamela, Zhou, Jing, Mackay, Sean, DeGottardi, Quinn, May, Damon H., Taniguchi, Ruth, Gittelman, Rachel M., Klinger, Mark, Snyder, Thomas M., Roper, Ryan, Wojciechowska, Gladys, Murray, Kim, Edmark, Rick, Evans, Simon, Jones, Lesley, Zhou, Yong, Rowen, Lee, Liu, Rachel, Chour, William, Algren, Heather A., Berrington, William R., Wallick, Julie A., Cochran, Rebecca A., Micikas, Mary E., Wrin, Terri, Petropoulos, Christos J., Cole, Hunter R., Fischer, Trevan D., Wei, Wei, Hoon, Dave S.B., Price, Nathan D., Subramanian, Naeha, Hill, Joshua A., Hadlock, Jennifer, Magis, Andrew T., Ribas, Antoni, Lanier, Lewis L., Boyd, Scott D., Bluestone, Jeffrey A., Chu, Helen, Hood, Leroy, Gottardo, Raphael, Greenberg, Philip D., Davis, Mark M., Goldman, Jason D., Heath, James R.

“…Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However, quantifiable risk factors for PASC and their biological associations are…”
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Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 by Sekine, Takuya, Perez-Potti, André, Rivera-Ballesteros, Olga, Strålin, Kristoffer, Gorin, Jean-Baptiste, Olsson, Annika, Llewellyn-Lacey, Sian, Kamal, Habiba, Bogdanovic, Gordana, Muschiol, Sandra, Wullimann, David J., Kammann, Tobias, Emgård, Johanna, Parrot, Tiphaine, Folkesson, Elin, Akber, Mira, Berglin, Lena, Bergsten, Helena, Brighenti, Susanna, Brownlie, Demi, Butrym, Marta, Chambers, Benedict, Chen, Puran, Jeannin, Martin Cornillet, Grip, Jonathan, Gomez, Angelica Cuapio, Dillner, Lena, Lozano, Isabel Diaz, Dzidic, Majda, Tullberg, Malin Flodström, Färnert, Anna, Glans, Hedvig, Haroun-Izquierdo, Alvaro, Henriksson, Elizabeth, Hertwig, Laura, Kalsum, Sadaf, Kokkinou, Efthymia, Kvedaraite, Egle, Loreti, Marco, Lourda, Magalini, Maleki, Kimia, Malmberg, Karl-Johan, Marquardt, Nicole, Maucourant, Christopher, Michaelsson, Jakob, Mjösberg, Jenny, Moll, Kirsten, Muva, Jagadees, Mårtensson, Johan, Nauclér, Pontus, Norrby-Teglund, Anna, Medina, Laura Palma, Persson, Björn, Radler, Lena, Ringqvist, Emma, Sandberg, John Tyler, Sohlberg, Ebba, Soini, Tea, Svensson, Mattias, Tynell, Janne, Varnaite, Renata, Kries, Andreas Von, Unge, Christian, Rooyackers, Olav, Eriksson, Lars I., Henter, Jan-Inge, Sönnerborg, Anders, Allander, Tobias, Albert, Jan, Nielsen, Morten, Klingström, Jonas, Gredmark-Russ, Sara, Björkström, Niklas K., Sandberg, Johan K., Price, David A., Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus

“…SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional…”
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SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues by Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Tzouanas, Constantine N., Cao, Yuming, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Yu, Alison, Gideon, Hannah P., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Kropski, Jonathan A., Theis, Fabian J., Schiller, Herbert B., Zaragosi, Laure-Emmanuelle, Barbry, Pascal, Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Garber, Manuel, Schmidt, Aaron G., Lingwood, Daniel, Shalek, Alex K., Ordovas-Montanes, Jose, Banovich, Nicholas, Barbry, Pascal, Desai, Tushar, Duong, Thu Elizabeth, Eickelberg, Oliver, Falk, Christine, Farzan, Michael, Glass, Ian, Haniffa, Muzlifah, Hung, Deborah, Kaminski, Naftali, Krasnow, Mark, Kuhnemund, Malte, Lafyatis, Robert, Lee, Haeock, Leroy, Sylvie, Lundeberg, Joakim, Meyer, Kerstin, Misharin, Alexander, Nawijn, Martijn, Nikolic, Marko Z., Ordovas-Montanes, Jose, Pe’er, Dana, Quake, Stephen, Rajagopal, Jay, Tata, Purushothama Rao, Regev, Aviv, Reyfman, Paul A., Rosen, Orit, Saeb-Parsy, Kourosh, Samakovlis, Christos, Schiller, Herbert, Schultze, Joachim L., Seibold, Max A., Shalek, Alex K., Shepherd, Douglas, Sun, Xin, Theis, Fabian, Tsankov, Alexander, von Papen, Michael, Whitsett, Jeffrey, Xavier, Ramnik, Xu, Yan, Zaragosi, Laure-Emmanuelle, Zhang, Kun

“…There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease…”
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The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic by Hoffmann, Markus, Krüger, Nadine, Schulz, Sebastian, Cossmann, Anne, Rocha, Cheila, Kempf, Amy, Nehlmeier, Inga, Graichen, Luise, Moldenhauer, Anna-Sophie, Winkler, Martin S., Lier, Martin, Dopfer-Jablonka, Alexandra, Jäck, Hans-Martin, Behrens, Georg M.N., Pöhlmann, Stefan

“…The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral…”
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