Search Results - "Celis, F."

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice by Syed, Ismail, Rubin de Celis, Maria F, Mohan, James F, Moraes-Vieira, Pedro M, Vijayakumar, Archana, Nelson, Andrew T, Siegel, Dionicio, Saghatelian, Alan, Mathis, Diane, Kahn, Barbara B

“…Palmitic acid esters of hydroxy stearic acids (PAHSAs) are endogenous antidiabetic and antiinflammatory lipids. Here, we show that PAHSAs protect against type…”
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PAHSAs reduce cellular senescence and protect pancreatic beta cells from metabolic stress through regulation of Mdm2/p53 by Rubin de Celis, Maria F, Garcia-Martin, Ruben, Syed, Ismail, Lee, Jennifer, Aguayo-Mazzucato, Cristina, Bonner-Weir, Susan, Kahn, Barbara B

“…Senescence in pancreatic beta cells plays a major role in beta cell dysfunction, which leads to impaired glucose homeostasis and diabetes. Therefore,…”
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Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes by Rubin de Celis, Maria F., Bonner-Weir, Susan

“…In this issue of Developmental Cell, Zhu et al. provide integrated data from single-cell/nuclei RNAseq and chromatin accessibility (ATAC) across both a…”
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Glucagon receptor antagonists might stimulate β-cell expansion by Rubin de Celis, Maria F., Bonner-Weir, Susan

“…In a recent issue of Cell Reports , Xi et al. reported on their studies of an anti-glucagon receptor antibody in several mouse models of insulin-deficient…”
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High activation and skewed T cell differentiation are associated with low IL‐17A levels in a hu‐PBL‐NSG‐SGM3 mouse model of HIV infection by Perdomo‐Celis, F., Medina‐Moreno, S., Davis, H., Bryant, J., Taborda, N. A., Rugeles, M. T., Kottilil, S., Zapata, J. C.

“…Summary The humanized NOD/SCID/IL‐2 receptor γ‐chainnull (NSG) mouse model has been widely used for the study of HIV pathogenesis. Here, NSG mice with…”
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Isolation and characterization of adrenocortical progenitors involved in the adaptation to stress by Steenblock, Charlotte, de Celis, Maria F. Rubin, Silva, Luis F. Delgadillo, Pawolski, Verena, Brennand, Ana, Werdermann, Martin, Berger, Ilona, Santambrogio, Alice, Peitzsch, Mirko, Andoniadou, Cynthia L., Schally, Andrew V., Bornstein, Stefan R.

“…The adrenal gland is a master regulator of the human body during response to stress. This organ shows constant replacement of senescent cells by newly…”
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Analysis of biomolecules in cochineal dyed archaeological textiles by surface-enhanced Raman spectroscopy by Celis, F., Segura, C., Gómez-Jeria, J. S., Campos-Vallette, M., Sanchez-Cortes, S.

“…SERS spectroscopy is successfully employed in this work to reveal different components integrating the cochineal colorant employed for dying archaeological…”
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Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation by García-Martín, Rubén, Alexaki, Vasileia I., Qin, Nan, Rubín de Celis, María F., Economopoulou, Matina, Ziogas, Athanasios, Gercken, Bettina, Kotlabova, Klara, Phieler, Julia, Ehrhart-Bornstein, Monika, Bornstein, Stefan R., Eisenhofer, Graeme, Breier, Georg, Blüher, Matthias, Hampe, Jochen, El-Armouche, Ali, Chatzigeorgiou, Antonios, Chung, Kyoung-Jin, Chavakis, Triantafyllos

“…Angiogenesis is a central regulator for white (WAT) and brown (BAT) adipose tissue adaptation in the course of obesity. Here we show that deletion of…”
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Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes by Rubin de Celis, Maria F., Bonner-Weir, Susan

“…Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has…”
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A refutation to ‘A new A-P compartment boundary and organizer in holometabolous insect wings’ by Lawrence, Peter A., Casal, José, Celis, José F. de, Morata, Ginés

“…We respond to a recent report by Abbasi and Marcus who present two main findings: first they argue that there is an organiser and a compartment boundary within…”
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Regulation and function of Spalt proteins during animal development by de Celis, Jose F, Barrio, Rosa

“…The genes of the spalt (sal) family play fundamental roles during animal development. The two members of this family in Drosophila, spalt (sal) and…”
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complex tale of the achaete-scute complex: a paradigmatic case in the analysis of gene organization and function during development by Garcia-Bellido, Antonio, Celis, Jose F. de

“…The achaete-scute gene complex (AS-C) contains four genes encoding transcription factors of the bHLH family, achaete, scute, lethal of scute, and asense…”
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EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis by Soler Beatty, Jennifer, Molnar, Cristina, Luque, Carlos M, de Celis, Jose F, Martín-Bermudo, María D

“…Activation of Ras signaling occurs in ~30% of human cancers. However, activated Ras alone is insufficient to produce malignancy. Thus, it is imperative to…”
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Pattern formation in the Drosophila wing: The development of the veins by de Celis, Jose F.

“…The veins are cuticular structures that differentiate in precise patterns in insect wings. The genetic and molecular basis of vein pattern formation in…”
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Patterning of the Drosophila L2 vein is driven by regulatory interactions between region-specific transcription factors expressed in response to Dpp signalling by Martín, Mercedes, Ostalé, Cristina M, de Celis, Jose F

“…Pattern formation relies on the generation of transcriptional landscapes regulated by signalling pathways. A paradigm of epithelial patterning is the…”
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Gain-of-Function Screen Identifying Genes Required for Growth and Pattern Formation of the Drosophila melanogaster Wing by Cruz, Cristina, Glavic, Alvaro, Casado, Mar, Celis, Jose F. de

“…The Drosophila melanogaster wing is a model system for analyzing the genetic control of organ size, shape, and pattern formation. The formation of the wing…”
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Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing by Ostalé, Cristina M, Esteban, Nuria, López-Varea, Ana, de Celis, Jose F

“…Abstract Protein kinases and phosphatases constitute a large family of conserved enzymes that control a variety of biological processes by regulating the…”
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THE TOMB OF IPI: 3D DOCUMENTATION IN A MIDDLE KINGDOM THEBAN NECROPOLIS (EGYPT, 2000 BCE) by Echeverría, E., Celis, F., Morales, A., da Casa, F.

“…Due to the multiplicity of tombs in the area and the work of early archaeologists in Deir el-Bahari, the necropolis resembles a Swiss cheese. In addition, most…”
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Surface-enhanced Raman scattering study of L-tryptophan by Aliaga, A. E., Osorio-Román, I., Leyton, P., Garrido, C., Cárcamo, J., Caniulef, C., Célis, F., Díaz F., G., Clavijo, E., Gómez-Jeria, J. S., Campos-Vallette, M. M.

“…Surface‐enhanced Raman scattering (SERS) spectra of tryptophan (Trp) were obtained. A unique SERS spectrum of Trp, corresponding to the most stable…”
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Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing by Molnar, Cristina, de Celis, Jose F

“…The regulation of Extracellular regulated kinase (Erk) activity is a key aspect of signalling by pathways activated by extracellular ligands acting through…”
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