3D Filaments Based on Polyhydroxy Butyrate—Micronized Bacterial Cellulose for Tissue Engineering Applications

3D Filaments Based on Polyhydroxy Butyrate—Micronized Bacterial Cellulose for Tissue Engineering Applications

In this work, scaffolds based on poly(hydroxybutyrate) (PHB) and micronized bacterial cellulose (BC) were produced through 3D printing. Filaments for the printing were obtained by varying the percentage of micronized BC (0.25, 0.50, 1.00, and 2.00%) inserted in relation to the PHB matrix. Despite th...

Full description

Saved in:
Bibliographic Details
Published in:Journal of functional biomaterials Vol. 14; no. 9; p. 464
Main Authors: Celestino, Matheus F., Lima, Lais R., Fontes, Marina, Batista, Igor T. S., Mulinari, Daniella R., Dametto, Alessandra, Rattes, Raphael A., Amaral, André C., Assunção, Rosana M. N., Ribeiro, Clovis A., Castro, Guillermo R., Barud, Hernane S.
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-09-2023
MDPI
Subjects:
3-D printers
3D printing
Additive manufacturing
Biocompatibility
Biomedical materials
Biopolymers
Cellulose
Circular economy
Composite materials
Cytotoxicity
Esters
Filaments
Fourier transforms
Functional groups
Infrared analysis
Infrared spectroscopy
Innovations
Mechanical properties
Melt temperature
micronized bacterial cellulose
Particle size
poly(hydroxybutyrate)
Polymerization
Polymers
Printing
Reagents
Scaffolds
Thermodynamic properties
Thermogravimetric analysis
Three dimensional printing
Tissue engineering
Brazil
Canada
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this work, scaffolds based on poly(hydroxybutyrate) (PHB) and micronized bacterial cellulose (BC) were produced through 3D printing. Filaments for the printing were obtained by varying the percentage of micronized BC (0.25, 0.50, 1.00, and 2.00%) inserted in relation to the PHB matrix. Despite the varying concentrations of BC, the biocomposite filaments predominantly contained PHB functional groups, as Fourier transform infrared spectroscopy (FTIR) demonstrated. Thermogravimetric analyses (i.e., TG and DTG) of the filaments showed that the peak temperature (Tpeak) of PHB degradation decreased as the concentration of BC increased, with the lowest being 248 °C, referring to the biocomposite filament PHB/2.0% BC, which has the highest concentration of BC. Although there was a variation in the thermal behavior of the filaments, it was not significant enough to make printing impossible, considering that the PHB melting temperature was 170 °C. Biological assays indicated the non-cytotoxicity of scaffolds and the provision of cell anchorage sites. The results obtained in this research open up new paths for the application of this innovation in tissue engineering.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb14090464