Search Results - "Celada, Franco"

Computer Modeling of Clonal Dominance: Memory-Anti-Naïve and Its Curbing by Attrition by Castiglione, Filippo, Ghersi, Dario, Celada, Franco

“…Experimental and computational studies have revealed that T-cell cross-reactivity is a widespread phenomenon that can either be advantageous or detrimental to…”
Get full text

Homage to Eli Sercarz by Celada, Franco

Get full text

Critical Reviews in Immunology by Celada, Franco

Get full text

Antibody‐mediated enzyme formation: Its legacy at age fifty‐four by Strom, Roberto, Celada, Franco

“…Antibody‐mediated enzyme formation is a phenomenon first described in 1968 and further studied by molecular Immunologists and Biochemists over the following…”
Get full text

Introduction: Knowledge is survival-The mission of the immune system and its stochastic simulations by Celada, Franco

“…In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of…”
Get full text

Modelling thymic functions in a cellular automaton by Morpurgo, D, Serenthà, R, Seiden, P E, Celada, F

“…Along the lines developed by Celada and Seiden, for simulating an immune system by means of cellular automata, we have constructed a 'thymus' where T cells…”
Get more information

IFN-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections by Bahl, Kapil, Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Selin, Liisa K, Welsh, Raymond M

“…Profound lymphopenia has been observed during many acute viral infections, and our laboratory has previously documented a type I IFN-dependent loss of CD8 T…”
Get full text

Polyspecificity of T cell and B cell receptor recognition by Wucherpfennig, Kai W, Allen, Paul M, Celada, Franco, Cohen, Irun R, De Boer, Rob, Garcia, K. Christopher, Goldstein, Byron, Greenspan, Ralph, Hafler, David, Hodgkin, Philip, Huseby, Erik S, Krakauer, David C, Nemazee, David, Perelson, Alan S, Pinilla, Clemencia, Strong, Roland K, Sercarz, Eli E

“…Abstract A recent workshop discussed the recognition of multiple distinct ligands by individual T cell and B cell receptors and the implications of this…”
Get full text

Broad cross-reactive TCR repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes by Clute, Shalyn C, Naumov, Yuri N, Watkin, Levi B, Aslan, Nuray, Sullivan, John L, Thorley-Lawson, David A, Luzuriaga, Katherine, Welsh, Raymond M, Puzone, Roberto, Celada, Franco, Selin, Liisa K

“…Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a…”
Get full text

Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity by Cornberg, Markus, Chen, Alex T, Wilkinson, Lee A, Brehm, Michael A, Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Welsh, Raymond M, Selin, Liisa K

“…Why some virus-specific CD8 TCR repertoires are diverse and others restricted or "oligoclonal" has been unknown. We show here that oligoclonality and extreme…”
Get full text

Heterologous immunity: Immunopathology, autoimmunity and protection during viral infections by Selin, Liisa K., Wlodarczyk, Myriam F., Kraft, Anke R., Nie, Siwei, Kenney, Laurie L., Puzone, Roberto, Celada, Franco

“…Heterologous immunity is a common phenomenon present in all infections. Most of the time it is beneficial, mediating protective immunity, but in some…”
Get full text

A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses by Cheng, Yiming, Ghersi, Dario, Calcagno, Claudia, Selin, Liisa K, Puzone, Roberto, Celada, Franco

“…Abstract In an agent-based computer model, we simulate the formation and recall of anti-virus immunological memory. Specifically we try to predict what will…”
Get full text

CD8 memory T cells: cross-reactivity and heterologous immunity by Selin, Liisa K., Cornberg, Markus, Brehm, Michael A., Kim, Sung-Kwon, Calcagno, Claudia, Ghersi, Dario, Puzone, Roberto, Celada, Franco, Welsh, Raymond M.

“…Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The…”
Get full text

Broad cross-reactive T cell receptor repertoires recognizing dissimilar Epstein-Barr and influenza A virus epitopes by Clute, Shalyn C., Naumov, Yuri N., Watkin, Levi B., Aslan, Nuray, Sullivan, John L., Thorley-Lawson, David A., Luzuriaga, Katherine, Welsh, Raymond M., Puzone, Roberto, Celada, Franco, Selin, Liisa K.

“…Memory T cells cross-reactive with epitopes encoded by related or even unrelated viruses may alter the immune response and pathogenesis of infection by a…”
Get full text

Use of bispecific hybrid antibodies for the development of a homogeneous enzyme immunoassay by Görög, G, Gandolfi, A, Paradisi, G, Rolleri, E, Klasen, E, Dessi, V, Strom, R, Celada, F

“…Hybrid bispecific monoclonal antibodies reacting with carcinoembryonal antigen (CEA) and with the E. coli enzyme beta-galactosidase (GZ) were produced by…”
Get more information

Systematic simulation of cross-reactivity predicts ambiguity in Tk memory: It may save lives of the infected, but limits specificities vital for further responses by Pearson, Yanthe E., Cheng, Yiming, Selin, Liisa K., Puzone, Roberto, Celada, Franco

“…The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory…”
Get full text

Affinity maturation and hypermutation in a simulation of the humoral immune response by Celada, F, Seiden, P E

“…By experimenting with a cellular automaton model of the immune system, we have reproduced affinity maturation of the antibody response, a somatic adaptation to…”
Get more information

Modelling the immune system: the case of situated cellular agents by Bandini, Stefania, Celada, Franco, Manzoni, Sara, Vizzari, Giuseppe

“…Issue Title: Special Issue: Natural and Artificial Immune Systems The immune system (IS) represents the defence mechanism of higher level organisms to micro…”
Get full text

A systematic approach to vaccine complexity using an automaton model of the cellular and humoral immune system: I. Viral characteristics and polarized responses by Kohler, Brynja, Puzone, Roberto, Seiden, Philip E, Celada, Franco

“…A modern approach to vaccination faces the compound complexity of microorganism behavior and immune response triggering and regulation. Since computational…”
Get full text

Computer simulations of heterologous immunity: Highlights of an interdisciplinary cooperation by Calcagno, Claudia, Puzone, Roberto, Pearson, Yanthe E., Cheng, Yiming, Ghersi, Dario, Selin, Liisa K., Welsh, Raymond M., Celada, Franco

“…The relationship between biological research and mathematical modeling is complex, critical, and vital. In this review, we summarize the results of the…”
Get full text