Impact of chlorogenic acid on surface and phase properties of cholesterol-enriched phosphatidylcholine membranes

This study analyses the insertion of Chlorogenic acid (CGA) in phosphatidylcholine (PC) membranes enriched with cholesterol (Chol). While cholesterol decreases the area per lipid and increases the dipole potential, CGA increases and decreases these values, respectively. When CGA is inserted into cho...

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Bibliographic Details
Published in:	Archives of biochemistry and biophysics Vol. 753; p. 109913
Main Authors:	Cejas, Jimena del P., Rosa, Antonio S., González Paz, Agustín N., Disalvo, Edgardo A., Frías, María de los A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2024
Subjects:	Chlorogenic acid Cholesterol Dipole potential FTIR Lipid monolayer Surface pressure Dipole potential Surface pressure Chlorogenic acid FTIR Cholesterol Lipid monolayer
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Summary:	This study analyses the insertion of Chlorogenic acid (CGA) in phosphatidylcholine (PC) membranes enriched with cholesterol (Chol). While cholesterol decreases the area per lipid and increases the dipole potential, CGA increases and decreases these values, respectively. When CGA is inserted into cholesterol-containing DMPC membranes, these effects cancel out, resulting in values that overlap with those of DMPC monolayers without Chol and CGA. The presence of CGA also compensates the increase of dipole potential produced by Chol which can be explain as a consequence of the orientation of CGA molecule at the interphase opposing the cholesterol dipole moieties and water dipoles. This compensatory effect is less effective when lipids lack carbonyl groups (CO). When monolayers are composed by unsaturated PCs the Chol compensation is found at higher concentrations of CGA due to the direct interaction between CGA and Chol. These results suggest that cholesterol modulates the interaction and distribution of CGA in the lipid membrane, which may have implications for its biological activity. [Display omitted] •CGA compensates cholesterol effect on the lipid membranes compression pattern.•Concentration for compensation depends on Carbonyl Groups and double bonds.•A direct cholesterol-CGA interaction affects the stability of lipid membranes.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0003-9861 1096-0384 1096-0384
DOI:	10.1016/j.abb.2024.109913