Search Results - "Cegla, Marek T."

Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents by Strekowski, Lucjan, Mokrosz, Jerzy L, Honkan, Vidya A, Czarny, Agnieszka, Cegla, Marek T, Wydra, Roman L, Patterson, Steven E, Schinazi, Raymond F

“…Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized…”
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Synthesis of the hypotensive agent 8-amino-7-[2-hydroxy-3-morpholinopropyl]theophylline (P23) and analogs by Cegla, Marek T., Potaczek, Joanna, Zylewski, Marek, Strekowski, Lucjan

“…Synthesis of a number of 7,8‐disubstituted theophyllines including enantiomers of the hypotensive agent P23 is described. J. Heterocyclic Chem., (2009)…”
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A new water-soluble ligand for efficient copper-catalyzed Huisgen cycloaddition of aliphatic azides and alkynes by Szafrański, Przemysław W., Kasza, Patryk, Cegła, Marek T.

“…[Display omitted] Efficient procedures for the copper-catalyzed Huisgen cycloaddition reaction in aqueous media were developed using a novel water-soluble…”
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Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives by Szafrański, Przemysław W., Siwek, Agata, Smaga-Maślanka, Irena, Pomierny-Chamioło, Lucyna, Ilnicki, Piotr, Żuchowski, Grzegorz, Nevalainen, Tapio, Filip, Małgorzata, Zajdel, Paweł, Cegła, Marek T.

“…•Exploration of 1,2,3-triazoles as potential CB1 receptor ligands - CB1 affinity tested for 19 compounds.•Efficient synthesis of 1,2,3-triazoles using a…”
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Fluorescent triazolyl spirooxazolidines: Synthesis and NMR stereochemical studies by Kasza, Patryk, Trybula, Marcela E., Baradziej, Katarzyna, Kepczynski, Mariusz, Szafrański, Przemysław W., Cegła, Marek T.

“…Carbon-heteoratom chemistry is a method of choice for rapid construction of complex molecules. In the recent decade, its various applications flourished thanks…”
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Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA by Strekowski, Lucjan, Cegla, Marek T., Honkan, Vidya, Buczak, Henryk, Winkeljohn, W. Rucks, Baumstark, Alfons L., Wilson, W. David

“…[Display omitted] Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex…”
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A route to sterically crowded benzophenone N-aryl imines by Strekowski, Lucjan, Cegla, Marek T, Harden, Donald B, Kong, Suk Bin

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Further studies on the cyclization of aromatic azomethines ortho-substituted with a trifluoromethyl group: synthesis of 2,4-di- or 2,3,4-trisubstituted quinolines by Strekowski, Lucjan, Patterson, Steven E, Janda, Lubomir, Wydra, Roman L, Harden, Donald B, Lipowska, Malgorzata, Cegla, Marek T

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Structure-activity relationship studies of central nervous system (CNS) agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor sites by Mokrosz, Jerzy L, Pietrasiewicz, Marzena, Duszynska, Beata, Cegla, Marek T

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An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline that involves the trifluoromethyl group: an expedient route to 2-arylquinolines by Strekowski, Lucjan, Wydra, Roman L, Cegla, Marek T, Czarny, Agnieszka, Harden, Donald B, Patterson, Steven E, Battiste, Merle A, Coxon, James M

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Efficient preparation of ketones from N-(ethoxymethylene)aniline and organometallic reagents by Strekowski, Lucjan, Wydra, Roman L, Cegla, Marek T, Czarny, Agnieszka, Patterson, Steven

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The NH(C)Br functionality of heteroaromatic compounds as a synthon for fused dihydrooxazoles by Cegla, Marek T., Baran, Marzena, Czarny, Agnieszka, Zylewski, Marek, Potaczek, Joanna, Klenc, Jeff, Strekowski, Lucjan

“…Fused dihydrooxazoles are produced by the reaction of 8‐bromoteophylline (1), 6‐bromo‐2‐pyridone (7), or 2‐bromobenzimidazole (11) with an N‐substituted…”
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A facile synthesis of 2-aryl- and 2-heteroaryl-substituted 4-aminoquinolines by STREKOWSKI, L, SUK-BIN KONG, CEGLA, M. T, HARDEN, D. B

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Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site by Mokrosz, J L, Pietrasiewicz, M, Duszyńska, B, Cegła, M T

“…The effect of the hydrocarbon chain of the model 4-substituted 1-(3-chlorophenyl)piperazines 12-31 on their affinity for 5-HT1A receptor sites was…”
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Novel rearrangement of 7-(substituted aminomethyl)-6,7-dihydrooxazolo[2,3- f]purines to 7-(substituted amino)-7,8-dihydro-6 H-[1,3]oxazino[2,3- f]purines by Cegła, Marek T., Potaczek, Joanna, Żylewski, Marek, Strekowski, Lucjan

“…[Display omitted] Oxazinopurines were obtained in high yield by the reaction of 8-bromotheophylline with morpholinomethyl-, piperidinomethyl- or…”
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Novel rearrangement of 7-(substituted aminomethyl)-6,7-dihydrooxazolo[2,3-f]purines to 7-(substituted amino)-7,8-dihydro-6H-[1,3]oxazino[2,3-f]purines by Cegła, Marek T., Potaczek, Joanna, Żylewski, Marek, Strekowski, Lucjan

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Synthesis of 2-chloro-4,6-di(heteroaryl)pyrimidines by Strekowski, Lucjan, Harden, Donald B., Grubb III, William B., Patterson, Steven E., Czarny, Agnieszka, Mokrosz, Maria J., Cegla, Marek T., Wydra, Roman L.

“…A practical method for the preparation of 2‐chloro‐4,6‐di(heteroaryl)pyrimidines and their 5‐methyl homologues from readily available 2‐chloropyrimidine and…”
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Synthesis of 2,2,4-trisubstituted-1,2-dihydroquinazolines by Strekowski, Lucjan, Cegla, Marek T., Kong, Suk-Bin, Harden, Donald B.

“…Synthesis of 2,2,4‐trisubstituted‐1,2‐dihydroquinazolines 6 from readily available 2‐aminobenzonitrile (1) is described. The scope and limitations of the…”
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Structure-activity relationship studies of CNS agents, Part 25. 4,6-di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as new, potent 5-HT2A receptor ligands: a verification of the topographic model by Mokrosz, M J, Strekowski, L, Kozak, W X, Duszyńska, B, Bojarski, A J, Kłodzinska, A, Czarny, A, Cegła, M T, Dereń-Wesoøek, A, Chojnacka-Wójcik, E

“…A series of new 4,6-di(heteroaryl)pyrimidines containing an N-methylpiperazino group (6-13) or an ethylenediamine chain (15-20) in position 2 were synthesized…”
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