Search Results - "Cegła, M T"

Following the oxidation state of organosulfur compounds with NMR: Experimental data versus DFT calculations and database-powered NMR prediction by Szafrański, P.W., Trybula, M.E., Kasza, P., Cegła, M.T.

“…The thioether-sulfoxide-sulfone oxidation ladder is a feature significant for drug synthesis and medicinal chemistry. The studies presented herein showed the…”
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Theophylline derivatives as potential histamine H3-receptor antagonists by Kieć-Kononowicz, K, Cegła, M T

“…Previous results of histamine H3-receptors investigations allowed to formulate a general structure of H3-receptor antagonists. According to this model a series…”
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4-Aryl-1-piperazinylalkyl derivatives of 1,2,3,4-tetrahydro-beta-carboline ring system. Synthesis and preliminary in vivo studies by Cegła, M T, Boksa, J, Chojnacka-Wójcik, E, Misztal, S

“…Three series of compounds containing a 4-aryl-1-piperazinylalkyl fragment attached to a different position of the indole (A) or…”
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Fluorescent triazolyl spirooxazolidines: Synthesis and NMR stereochemical studies by Kasza, Patryk, Trybula, Marcela E., Baradziej, Katarzyna, Kepczynski, Mariusz, Szafrański, Przemysław W., Cegła, Marek T.

“…Carbon-heteoratom chemistry is a method of choice for rapid construction of complex molecules. In the recent decade, its various applications flourished thanks…”
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Synthesis and quantitative structure-activity relationship analysis of 2-(aryl or heteroaryl)quinolin-4-amines, a new class of anti-HIV-1 agents by Strekowski, Lucjan, Mokrosz, Jerzy L, Honkan, Vidya A, Czarny, Agnieszka, Cegla, Marek T, Wydra, Roman L, Patterson, Steven E, Schinazi, Raymond F

“…Thirty-eight 2-(aryl or heteroaryl)quinolin-4-amines, N,N-disubstituted, N-monosubstituted, and without a substituent at the amino group have been synthesized…”
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Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site by Mokrosz, J L, Pietrasiewicz, M, Duszyńska, B, Cegła, M T

“…The effect of the hydrocarbon chain of the model 4-substituted 1-(3-chlorophenyl)piperazines 12-31 on their affinity for 5-HT1A receptor sites was…”
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A route to sterically crowded benzophenone N-aryl imines by Strekowski, Lucjan, Cegla, Marek T, Harden, Donald B, Kong, Suk Bin

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Synthesis of 2-chloro-4,6-di(heteroaryl)pyrimidines by Strekowski, Lucjan, Harden, Donald B., Grubb III, William B., Patterson, Steven E., Czarny, Agnieszka, Mokrosz, Maria J., Cegla, Marek T., Wydra, Roman L.

“…A practical method for the preparation of 2‐chloro‐4,6‐di(heteroaryl)pyrimidines and their 5‐methyl homologues from readily available 2‐chloropyrimidine and…”
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Structure-activity relationship studies of CNS agents, Part 25. 4,6-di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as new, potent 5-HT2A receptor ligands: a verification of the topographic model by Mokrosz, M J, Strekowski, L, Kozak, W X, Duszyńska, B, Bojarski, A J, Kłodzinska, A, Czarny, A, Cegła, M T, Dereń-Wesoøek, A, Chojnacka-Wójcik, E

“…A series of new 4,6-di(heteroaryl)pyrimidines containing an N-methylpiperazino group (6-13) or an ethylenediamine chain (15-20) in position 2 were synthesized…”
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Synthesis of 2,2,4-trisubstituted-1,2-dihydroquinazolines by Strekowski, Lucjan, Cegla, Marek T., Kong, Suk-Bin, Harden, Donald B.

“…Synthesis of 2,2,4‐trisubstituted‐1,2‐dihydroquinazolines 6 from readily available 2‐aminobenzonitrile (1) is described. The scope and limitations of the…”
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Structure-activity relationship studies of CNS agents. Part 9: 5-HT1A and 5-HT2 receptor affinity of some 2- and 3-substituted 1,2,3,4-tetrahydro-beta-carbolines by Bojarski, A J, Cegła, M T, Charakchieva-Minol, S, Mokrosz, M J, Maćkowiak, M, Misztal, S, Mokrosz, J L

“…The 5-HT1A and 5-HT2 receptor affinity of 2- and 3-substituted 1,2,3,4-tetrahydro-beta-carbolines 1-8, 10 and 12-15 has been determined. It has been found that…”
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Novel rearrangement of 7-(substituted aminomethyl)-6,7-dihydrooxazolo[2,3-f]purines to 7-(substituted amino)-7,8-dihydro-6H-[1,3]oxazino[2,3-f]purines by Cegła, Marek T., Potaczek, Joanna, Żylewski, Marek, Strekowski, Lucjan

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Structure-activity relationship studies of CNS agents. Part VIII. Bulk tolerance around the protonation center of 4-substituted 1-(3-chlorophenyl)piperazines at 5-HT1A and 5-HT2 receptors by Mokrosz, J L, Charakchieva-Minol, S, Paluchowska, M H, Cegła, M T

“…The effect of a steric hindrance around the protonation center of the model 4-substituted 1-(3-chlorophenyl)-piperazines 1-9 and 11-14 on their affinity for…”
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Structure-activity relationship studies of central nervous system agents. V: Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site by MOKROSZ, J. L, PIETRASIEWICZ, M, DUSZYNSKA, B, CEGLA, M. T

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Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT sub(1A) receptor site by Mokrosz, J L, Pietrasiewicz, M, Duszynska, B, Cegla, M T

“…The effect of the hydrocarbon chain of the model 4-substituted 1-(3-chlorophenyl)piperazines 12-31 on their affinity for 5-HT sub(1A) receptor sites was…”
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Further studies on the cyclization of aromatic azomethines ortho-substituted with a trifluoromethyl group: synthesis of 2,4-di- or 2,3,4-trisubstituted quinolines by Strekowski, Lucjan, Patterson, Steven E, Janda, Lubomir, Wydra, Roman L, Harden, Donald B, Lipowska, Malgorzata, Cegla, Marek T

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Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA by Strekowski, Lucjan, Cegla, Marek T., Honkan, Vidya, Buczak, Henryk, Winkeljohn, W. Rucks, Baumstark, Alfons L., Wilson, W. David

“…[Display omitted] Thienylpyrimidines substituted at position 2 of the pyrimidine with a chiral aminoalkoxy group were synthesized. Upon interaction with duplex…”
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An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline : that involves the trifluoromethyl group : an expedient route ot 2-arylquinolines by STREKOWSKI, L, WYDRA, R. L, CEGLA, M. T, CZARNY, A, HARDEN, D. B, PATTERSON, S. E, BATTISTE, M. A, COXON, J. M

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A facile synthesis of 2-aryl- and 2-heteroaryl-substituted 4-aminoquinolines by STREKOWSKI, L, SUK-BIN KONG, CEGLA, M. T, HARDEN, D. B

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An unusual base-mediated cyclization of ketimines derived from 2-(trifluoromethyl)aniline that involves the trifluoromethyl group: an expedient route to 2-arylquinolines by Strekowski, Lucjan, Wydra, Roman L, Cegla, Marek T, Czarny, Agnieszka, Harden, Donald B, Patterson, Steven E, Battiste, Merle A, Coxon, James M

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