Search Results - "Cedeño, David"
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Modulation of neuroglial interactions using differential target multiplexed spinal cord stimulation in an animal model of neuropathic pain
Published in Molecular pain (2020)“…The development and maintenance of chronic neuropathic pain involves distorted neuroglial interactions, which result in prolonged perturbations of immune and…”
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Spinal cord stimulation using differential target multiplexed programming modulates neural cell-specific transcriptomes in an animal model of neuropathic pain
Published in Molecular pain (2020)“…Spinal cord stimulation is a proven effective therapy for treating chronic neuropathic pain. Previous work in our laboratory demonstrated that spinal cord…”
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Differential target multiplexed spinal cord stimulation programming modulates proteins involved in ion regulation in an animal model of neuropathic pain
Published in Molecular pain (01-01-2022)“…The effect of spinal cord stimulation (SCS) using differential target multiplexed programming (DTMP) on proteins involved in the regulation of ion transport in…”
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Modulation of microglial activation states by spinal cord stimulation in an animal model of neuropathic pain: Comparing high rate, low rate, and differential target multiplexed programming
Published in Molecular pain (2021)“…While numerous studies and patient experiences have demonstrated the efficacy of spinal cord stimulation as a treatment for chronic neuropathic pain, the exact…”
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Proteomic and Phosphoproteomic Changes of MAPK-Related Inflammatory Response in an Animal Model of Neuropathic Pain by Differential Target Multiplexed SCS and Low-Rate SCS
Published in Journal of pain research (01-01-2022)“…Neuropathic pain initiates an interplay of pathways, involving MAP kinases and NFκB-signaling, leading to expression of immune response factors and activation…”
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Genomics of the Effect of Spinal Cord Stimulation on an Animal Model of Neuropathic Pain
Published in Neuromodulation (Malden, Mass.) (01-08-2016)“…Few studies have evaluated single-gene changes modulated by spinal cord stimulation (SCS), providing a narrow understanding of molecular changes. Genomics…”
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European randomized controlled trial evaluating differential target multiplexed spinal cord stimulation and conventional medical management in subjects with persistent back pain ineligible for spine surgery: 24‐month results
Published in European journal of pain (01-11-2024)“…Background Differential target multiplexed spinal cord stimulation (DTM SCS) was shown to be superior to conventional SCS for treating chronic low back pain…”
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Non-invasive Vagus Nerve Stimulation for COVID-19: Results From a Randomized Controlled Trial (SAVIOR I)
Published in Frontiers in neurology (08-04-2022)“…Severe coronavirus disease 2019 (COVID-19) is characterized, in part, by an excessive inflammatory response. Evidence from animal and human studies suggests…”
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Effect of stimulation intensity of a differential target multiplexed SCS program in an animal model of neuropathic pain
Published in Pain practice (01-07-2023)“…Background Spinal cord stimulation (SCS) has been proven to be an effective treatment for patients suffering from intractable chronic neuropathic pain. Recent…”
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Synthesis of Novel Quaternary Ammonium Salts and Their in Vitro Antileishmanial Activity and U-937 Cell Cytotoxicity
Published in Molecules (Basel, Switzerland) (29-03-2016)“…This work describes the synthesis of a series of quaternary ammonium salts and the assessment of their in vitro antileishmanial activity and cytotoxicity. A…”
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In Vitro and In Vivo Studies of the Utility of Dimethyl and Diethyl Carbaporphyrin Ketals in Treatment of Cutaneous Leishmaniasis
Published in Antimicrobial Agents and Chemotherapy (01-10-2011)“…Carbaporphyrin ketals are porphyrinoid compounds in which a pyrrole ring of a typical porphyrin macrocycle has been replaced by a ketal-substituted indene…”
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Sustainable conversion of coffee and other crop wastes to biofuels and bioproducts using coupled biochemical and thermochemical processes in a multi-stage biorefinery concept
Published in Applied microbiology and biotechnology (01-10-2014)“…The environmental impact of agricultural waste from the processing of food and feed crops is an increasing concern worldwide. Concerted efforts are underway to…”
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Spinal Evoked Compound Action Potentials in Rats With Clinically Relevant Stimulation Modalities
Published in Neuromodulation (Malden, Mass.) (01-01-2023)“…Rats are commonly used for translational pain and spinal cord stimulation (SCS) research. Although many SCS parameters are configured identically between rats…”
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Spinal Cord Stimulation Modulates Gene Expression in the Spinal Cord of an Animal Model of Peripheral Nerve Injury
Published in Regional anesthesia and pain medicine (01-11-2016)“…BACKGROUND AND OBJECTIVESPreviously, we found that application of pulsed radiofrequency to a peripheral nerve injury induces changes in key genes regulating…”
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Anatomic and Ultrasonographic Evaluation of the Knee Sensory Innervation: A Cadaveric Study to Determine Anatomic Targets in the Treatment of Chronic Knee Pain
Published in Regional anesthesia and pain medicine (01-01-2017)“…BACKGROUND AND OBJECTIVESOsteoarthrosis is a main cause of knee pain in the elderly. Pain associated with this condition is often refractory to conservative…”
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Modulation of Glia-Mediated Processes by Spinal Cord Stimulation in Animal Models of Neuropathic Pain
Published in Frontiers in pain research (Lausanne, Switzerland) (14-07-2021)“…Glial cells play an essential role in maintaining the proper functioning of the nervous system. They are more abundant than neurons in most neural tissues and…”
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Regulation of Expression of Extracellular Matrix Proteins by Differential Target Multiplexed Spinal Cord Stimulation (SCS) and Traditional Low-Rate SCS in a Rat Nerve Injury Model
Published in Biology (Basel, Switzerland) (31-03-2023)“…There is limited research on the association between the extracellular matrix (ECM) and chronic neuropathic pain. The objective of this study was twofold…”
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Acute Epidural Hematoma Formation in Cervical Spine After Interlaminar Epidural Steroid Injection Despite Discontinuation of Clopidogrel
Published in Regional anesthesia and pain medicine (01-05-2016)“…BACKGROUNDPerioperative management of patients on anticoagulant therapy prior to interventional pain procedures creates a challenge when balancing the risk of…”
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Glia to neuron ratio in the posterior aspect of the human spinal cord at thoracic segments relevant to spinal cord stimulation
Published in Journal of anatomy (01-11-2019)“…Spinal cord stimulation (SCS) applied between T8 and T11 segments has been shown to be effective for the treatment of chronic pain of the lower back and limbs…”
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Changes in Dorsal Root Ganglion Gene Expression in Response to Spinal Cord Stimulation
Published in Regional anesthesia and pain medicine (01-03-2017)“…BACKGROUND AND OBJECTIVESSpinal cord stimulation (SCS) has been shown to influence pain-related genes in the spinal cord directly under the stimulating…”
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