Search Results - "Cecilia Garlanda"

Macrophages as tools and targets in cancer therapy by Mantovani, Alberto, Allavena, Paola, Marchesi, Federica, Garlanda, Cecilia

“…Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular…”
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IL‐1 and IL‐1 regulatory pathways in cancer progression and therapy by Mantovani, Alberto, Barajon, Isabella, Garlanda, Cecilia

“…Summary Inflammation is an important component of the tumor microenvironment. IL‐1 is an inflammatory cytokine which plays a key role in carcinogenesis and…”
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Complement as a target in COVID-19? by Risitano, Antonio M., Mastellos, Dimitrios C., Huber-Lang, Markus, Yancopoulou, Despina, Garlanda, Cecilia, Ciceri, Fabio, Lambris, John D.

“…There is an urgent need to develop effective therapies for COVID-19. Here, we urge immunologists and clinicians to consider the potential of targeting the…”
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PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer by Garlanda, Cecilia, Bottazzi, Barbara, Magrini, Elena, Inforzato, Antonio, Mantovani, Alberto

“…Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component…”
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Tumor-associated myeloid cells: diversity and therapeutic targeting by Mantovani, Alberto, Marchesi, Federica, Jaillon, Sebastien, Garlanda, Cecilia, Allavena, Paola

“…Myeloid cells in tumor tissues constitute a dynamic immune population characterized by a non-uniform phenotype and diverse functional activities. Both…”
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Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance by Allavena, Paola, Sica, Antonio, Garlanda, Cecilia, Mantovani, Alberto

“…An intrinsic (oncogene-driven) pathway and an extrinsic (microenvironment-driven) pathway connect inflammatory reactions and cancer. M2-polarized…”
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Tumor associated macrophages and neutrophils in tumor progression by Galdiero, Maria R., Garlanda, Cecilia, Jaillon, Sébastien, Marone, Gianni, Mantovani, Alberto

“…Tumor‐associated macrophages (TAMs) are a key component of the tumor microenvironment and orchestrate various aspects of cancer. Diversity and plasticity are…”
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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19 by Brunetta, Enrico, Folci, Marco, Bottazzi, Barbara, De Santis, Maria, Gritti, Giuseppe, Protti, Alessandro, Mapelli, Sarah N., Bonovas, Stefanos, Piovani, Daniele, Leone, Roberto, My, Ilaria, Zanon, Veronica, Spata, Gianmarco, Bacci, Monica, Supino, Domenico, Carnevale, Silvia, Sironi, Marina, Davoudian, Sadaf, Peano, Clelia, Landi, Francesco, Di Marco, Fabiano, Raimondi, Federico, Gianatti, Andrea, Angelini, Claudio, Rambaldi, Alessandro, Garlanda, Cecilia, Ciccarelli, Michele, Cecconi, Maurizio, Mantovani, Alberto

“…Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of…”
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The Dual Complexity of PTX3 in Health and Disease: A Balancing Act? by Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia

“…The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as…”
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The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer by Doni, Andrea, Stravalaci, Matteo, Inforzato, Antonio, Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia, Bottazzi, Barbara

“…The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and…”
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An integrated view of humoral innate immunity: pentraxins as a paradigm by Bottazzi, Barbara, Doni, Andrea, Garlanda, Cecilia, Mantovani, Alberto

“…The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are…”
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Tumor associated macrophages and neutrophils in cancer by Galdiero, Maria Rosaria, Bonavita, Eduardo, Barajon, Isabella, Garlanda, Cecilia, Mantovani, Alberto, Jaillon, Sébastien

“…Abstract The tumor microenvironment is a complex framework, in which myeloid cells play important roles in sculpting cancer development from tumor initiation…”
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Pentraxins in the activation and regulation of innate immunity by Daigo, Kenji, Inforzato, Antonio, Barajon, Isabella, Garlanda, Cecilia, Bottazzi, Barbara, Meri, Seppo, Mantovani, Alberto

“…Summary Humoral fluid phase pattern recognition molecules (PRMs) are a key component of the activation and regulation of innate immunity. Humoral PRMs are…”
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Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules by Stravalaci, Matteo, Pagani, Isabel, Paraboschi, Elvezia Maria, Pedotti, Mattia, Doni, Andrea, Scavello, Francesco, Mapelli, Sarah N., Sironi, Marina, Perucchini, Chiara, Varani, Luca, Matkovic, Milos, Cavalli, Andrea, Cesana, Daniela, Gallina, Pierangela, Pedemonte, Nicoletta, Capurro, Valeria, Clementi, Nicola, Mancini, Nicasio, Invernizzi, Pietro, Bayarri-Olmos, Rafael, Garred, Peter, Rappuoli, Rino, Duga, Stefano, Bottazzi, Barbara, Uguccioni, Mariagrazia, Asselta, Rosanna, Vicenzi, Elisa, Mantovani, Alberto, Garlanda, Cecilia

“…The humoral arm of innate immunity includes diverse molecules with antibody-like functions, some of which serve as disease severity biomarkers in coronavirus…”
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Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure by Lombardi, Marta, Parolisi, Roberta, Scaroni, Federica, Bonfanti, Elisabetta, Gualerzi, Alice, Gabrielli, Martina, Kerlero de Rosbo, Nicole, Uccelli, Antonio, Giussani, Paola, Viani, Paola, Garlanda, Cecilia, Abbracchio, Maria P., Chaabane, Linda, Buffo, Annalisa, Fumagalli, Marta, Verderio, Claudia

“…Microglia are highly plastic immune cells which exist in a continuum of activation states. By shaping the function of oligodendrocyte precursor cells (OPCs),…”
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Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3 by Mantovani, Alberto, Garlanda, Cecilia, Doni, Andrea, Bottazzi, Barbara

“…Pentraxins are a family of multimeric pattern-recognition proteins highly conserved in evolution. Based on the primary structure of the subunit, the pentraxins…”
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Complement C3 vs C5 inhibition in severe COVID-19: Early clinical findings reveal differential biological efficacy by Mastellos, Dimitrios C., Pires da Silva, Bruno G.P., Fonseca, Benedito A.L., Fonseca, Natasha P., Auxiliadora-Martins, Maria, Mastaglio, Sara, Ruggeri, Annalisa, Sironi, Marina, Radermacher, Peter, Chrysanthopoulou, Akrivi, Skendros, Panagiotis, Ritis, Konstantinos, Manfra, Ilenia, Iacobelli, Simona, Huber-Lang, Markus, Nilsson, Bo, Yancopoulou, Despina, Connolly, E. Sander, Garlanda, Cecilia, Ciceri, Fabio, Risitano, Antonio M., Calado, Rodrigo T., Lambris, John D.

“…Growing clinical evidence has implicated complement as a pivotal driver of COVID-19 immunopathology. Deregulated complement activation may fuel cytokine-driven…”
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Extracellular forms of IL-37 inhibit innate inflammation in vitro and in vivo but require the IL-1 family decoy receptor IL-1R8 by Li, Suzhao, Neff, C. Preston, Barber, Kristina, Hong, Jaewoo, Luo, Yuchun, Azam, Tania, Palmer, Brent E., Fujita, Mayumi, Garlanda, Cecilia, Mantovani, Alberto, Kim, Soohyun, Dinarello, Charles Anthony

“…Significance Interleukin-1 family members are highly inflammatory but IL-37 member broadly suppresses inflammation and specific immunity. Initially, the…”
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Negative regulatory receptors of the IL-1 family by Garlanda, Cecilia, Riva, Federica, Bonavita, Eduardo, Mantovani, Alberto

“…Abstract The IL-1 family of ligands and receptors has a central role in both innate and adaptive immune responses and is tightly controlled by antagonists,…”
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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch by Lee, Jacob S, Cella, Marina, McDonald, Keely G, Garlanda, Cecilia, Kennedy, Gregory D, Nukaya, Manabu, Mantovani, Alberto, Kopan, Raphael, Bradfield, Christopher A, Newberry, Rodney D, Colonna, Marco

“…The generation of certain gut innate lymphoid cell (ILC) populations requires the aryl hydrocarbon receptor (AHR). Colonna and colleagues show that the…”
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