Search Results - "Cecchini, Matthew J."

Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis by Kareta, Michael S., Gorges, Laura L., Hafeez, Sana, Benayoun, Bérénice A., Marro, Samuele, Zmoos, Anne-Flore, Cecchini, Matthew J., Spacek, Damek, Batista, Luis F.Z., O’Brien, Megan, Ng, Yi-Han, Ang, Cheen Euong, Vaka, Dedeepya, Artandi, Steven E., Dick, Frederick A., Brunet, Anne, Sage, Julien, Wernig, Marius

“…Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of…”
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Comprehensive gene expression profiling identifies distinct and overlapping transcriptional profiles in non-specific interstitial pneumonia and idiopathic pulmonary fibrosis by Cecchini, Matthew J, Hosein, Karishma, Howlett, Christopher J, Joseph, Mariamma, Mura, Marco

“…The clinical-radiographic distinction between idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP) is challenging. We sought to…”
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An RB-EZH2 Complex Mediates Silencing of Repetitive DNA Sequences by Ishak, Charles A., Marshall, Aren E., Passos, Daniel T., White, Carlee R., Kim, Seung J., Cecchini, Matthew J., Ferwati, Sara, MacDonald, William A., Howlett, Christopher J., Welch, Ian D., Rubin, Seth M., Mann, Mellissa R.W., Dick, Frederick A.

“…Repetitive genomic regions include tandem sequence repeats and interspersed repeats, such as endogenous retroviruses and LINE-1 elements. Repressive…”
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Tumor-Infiltrating T Cells in EBV-Associated Gastric Carcinomas Exhibit High Levels of Multiple Markers of Activation, Effector Gene Expression, and Exhaustion by Salnikov, Mikhail, Prusinkiewicz, Martin A, Lin, Sherman, Ghasemi, Farhad, Cecchini, Matthew J, Mymryk, Joe S

“…Epstein-Barr virus (EBV) is a gamma-herpesvirus associated with 10% of all gastric cancers (GCs) and 1.5% of all human cancers. EBV-associated GCs (EBVaGCs)…”
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Spatially resolved gene expression profiles of fibrosing interstitial lung diseases by Kim, Seung J., Cecchini, Matthew J., Woo, Elissa, Jayawardena, Nathashi, Passos, Daniel T., Dick, Frederick A., Mura, Marco

“…Fibrosing interstitial lung diseases (ILDs) encompass a diverse range of scarring disorders that lead to progressive lung failure. Previous gene expression…”
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Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival by Keow, Jonathan, Cecchini, Matthew J, Jayawardena, Nathashi, Zompatori, Maurizio, Joseph, Mariamma G, Mura, Marco

“…Idiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and subsequent induction…”
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The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein by Cecchini, Matthew J, Dick, Frederick A

“…The pRB (retinoblastoma protein) has a central role in the control of the G(1)-S phase transition of the cell cycle that is mediated in part through the…”
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Using deep learning to predict tumor mutational burden from scans of H&E-stained multicenter slides of lung squamous cell carcinoma by Dammak, Salma, Cecchini, Matthew J, Breadner, Daniel, Ward, Aaron D

“…A high tumor mutational burden (TMB) is a promising biomarker for identifying lung squamous cell carcinoma (SqCC) patients who are more likely to benefit from…”
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Validation of the risk stratification score in idiopathic pulmonary fibrosis: study protocol of a prospective, multi-centre, observational, 3-year clinical trial by Manzetti, Gian Marco, Hosein, Karishma, Cecchini, Matthew J, Kwan, Keith, Abdelrazek, Mohamed, Zompatori, Maurizio, Rogliani, Paola, Mura, Marco

“…Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and considerable variability in the…”
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Haploinsufficiency of an RB-E2F1-Condensin II complex leads to aberrant replication and aneuploidy by Coschi, Courtney H, Ishak, Charles A, Gallo, David, Marshall, Aren, Talluri, Srikanth, Wang, Jianxin, Cecchini, Matthew J, Martens, Alison L, Percy, Vanessa, Welch, Ian, Boutros, Paul C, Brown, Grant W, Dick, Frederick A

“…Genome instability is a characteristic of malignant cells; however, evidence for its contribution to tumorigenesis has been enigmatic. In this study, we…”
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Context dependent roles for RB-E2F transcriptional regulation in tumor suppression by Thwaites, Michael J, Cecchini, Matthew J, Passos, Daniel T, Zakirova, Komila, Dick, Frederick A

“…RB-E2F transcriptional control plays a key role in regulating the timing of cell cycle progression from G1 to S-phase in response to growth factor stimulation…”
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Analysis of cell cycle position in mammalian cells by Cecchini, Matthew J, Amiri, Mehdi, Dick, Frederick A

“…The regulation of cell proliferation is central to tissue morphogenesis during the development of multicellular organisms. Furthermore, loss of control of cell…”
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Pathways to Precision: Guideline for Programmed Death Ligand-1 and Tumor Mutation Burden Testing to Support the Selection of Immune Checkpoint Therapies in Lung Cancer by Cecchini, Matthew J

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Loss of the retinoblastoma tumor suppressor correlates with improved outcome in patients with lung adenocarcinoma treated with surgery and chemotherapy by Cecchini, Matthew J., MD, PhD, Ishak, Charles A., BSc, Passos, Daniel T., DVM, PhD, Warner, Andrew, MSc, Palma, David A., MD, PhD, FRCPC, Howlett, Christopher J., MD, PhD, FRCPC, Driman, David K., MBChB, FRCPC, Dick, Frederick A., PhD

“…Summary The retinoblastoma tumor suppressor pathway is frequently inactivated in human cancer, enabling unrestrained proliferation. Most cancers, however,…”
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Osteopontin lung gene expression is a marker of disease severity in pulmonary arterial hypertension by Mura, Marco, Cecchini, Matthew J., Joseph, Mariamma, Granton, John T.

“…ABSTRACT Background and objective Osteopontin (OPN) is a pleiotropic cytokine involved in the proliferation of pulmonary artery smooth muscle cells (PA‐SMC)…”
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Pathology of Vaping-Associated Lung Injury by Butt, Yasmeen M, Smith, Maxwell L, Tazelaar, Henry D, Vaszar, Laszlo T, Swanson, Karen L, Cecchini, Matthew J, Boland, Jennifer M, Bois, Melanie C, Boyum, James H, Froemming, Adam T, Khoor, Andras, Mira-Avendano, Isabel, Patel, Aiyub, Larsen, Brandon T

“…This letter describes findings in 17 patients with a history of vaping who had lung biopsies after presenting with symptoms and bilateral pulmonary opacities…”
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Implementing a structured digital-based online pathology curriculum for trainees at the time of COVID-19 by Roy, Simon F, Cecchini, Matthew J

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Determination of Ki-67 indices in neuroendocrine tumours of the gastrointestinal tract: the past, the present, and the future by Houpt, Jacob A., Liu, Eric, Wang, Hui, Cecchini, Matthew J., Ling, Charles, Zhang, Qi

“…Ki-67 index (Ki-67i) is integral to the grading of many tumours. There remains considerable variability across pathologists in methods used to determine Ki-67i…”
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Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023 by Tian, Roland, Wang, Eric, Sivasubramaniam, Priyadharshini, Baskota, Swikrity U, Sharma, Anurag, Cecchini, Matthew J

“…Social media is a powerful tool in pathology education and professional networking that connects pathologists and pathology trainees from around the world…”
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Pathologists in pursuit of the COVID-19 culprit by Yi, Eunhee S, Cecchini, Matthew J, Bois, Melanie C

“…In addition to pneumonia and respiratory failure, thromboembolic events (sometimes clinically unsuspected at death) are common, according to a 12-case autopsy…”
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