Search Results - "Ceccarelli, Simona M"

Carnitine Palmitoyltransferase (CPT) Modulators: A Medicinal Chemistry Perspective on 35 Years of Research by Ceccarelli, Simona M, Chomienne, Odile, Gubler, Marcel, Arduini, Arduino

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Metabolite Identification via LC-SPE-NMR-MS of the In vitro Biooxidation Products of a Lead mGlu5 Allosteric Antagonist and Impact on the Improvement of Metabolic Stability in the Series by Ceccarelli, Simona M., Schlotterbeck, Götz, Boissin, Patrick, Binder, Martin, Buettelmann, Bernd, Hanlon, Steven, Jaeschke, Georg, Kolczewski, Sabine, Kupfer, Ernst, Peters, Jens-Uwe, Porter, Richard H. P., Prinssen, Eric P., Rueher, Marianne, Ruf, Iris, Spooren, Will, Stämpfli, Andreas, Vieira, Eric

“…Detailed information on the metabolic fate of lead compounds can be a powerful tool for an informed approach to the stabilization of metabolically labile…”
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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors by Kühne, Holger, Obst-Sander, Ulrike, Kuhn, Bernd, Conte, Aurelia, Ceccarelli, Simona M., Neidhart, Werner, Rudolph, Markus G., Ottaviani, Giorgio, Gasser, Rodolfo, So, Sung-Sau, Li, Shirley, Zhang, Xiaolei, Gao, Lin, Myers, Michael

“…[Display omitted] Dual inhibition of fatty acid binding proteins 4 and 5 (FABP4 and FABP5) is expected to provide beneficial effects on a number of metabolic…”
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LC-SPE-NMR-MS: a total analysis system for bioanalysis by Schlotterbeck, Götz, Ceccarelli, Simona M

“…Liquid chromatography (LC)-solid-phase extraction (SPE)-nuclear magnetic resonance (NMR)-mass spectrometry (MS) coupling is a key technology for fast and…”
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Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure by Ceccarelli, Simona M., Jaeschke, Georg, Buettelmann, Bernd, Huwyler, Jörg, Kolczewski, Sabine, Peters, Jens-Uwe, Prinssen, Eric, Porter, Richard, Spooren, Will, Vieira, Eric

“…A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the…”
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Discovery of N-(2-aryl-cyclohexyl) substituted spiropiperidines as a novel class of GlyT1 inhibitors by Pinard, Emmanuel, Ceccarelli, Simona M., Stalder, Henri, Alberati, Daniela

“…Screening of the Roche compound library led to the identification of cis- N-(2-phenyl-cyclohexyl)-spiropiperidine 1 as structurally novel GlyT1 inhibitor. The…”
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Discovery of N-(2-hydroxy-2-aryl-cyclohexyl) substituted spiropiperidines as GlyT1 antagonists with improved pharmacological profile by Ceccarelli, Simona M., Pinard, Emmanuel, Stalder, Henri, Alberati, Daniela

“…During SAR exploration of N-(2-aryl-cyclohexyl) substituted spiropiperidine as GlyT1 inhibitors, it was found that introduction of a hydroxy group in position…”
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Synthetic studies on the sarcodictyins: synthesis of fully functionalized cyclization precursors by Ceccarelli, Simona M, Piarulli, Umberto, Gennari, Cesare

“…A strategy featuring a key retrosynthetic disconnection at the C2–C3 position was applied to the total synthesis of the common diterpenoid tricyclic skeleton…”
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Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists by Jaeschke, Georg, Porter, Richard, Büttelmann, Bernd, Ceccarelli, Simona M., Guba, Wolfgang, Kuhn, Bernd, Kolczewski, Sabine, Huwyler, Jörg, Mutel, Vincent, Peters, Jens-Uwe, Ballard, Theresa, Prinssen, Eric, Vieira, Eric, Wichmann, Jürgen, Spooren, Will

“…Optimization of affinity and microsomal stability led to identification of the potent, metabolically stable fenobam analog 4l. Robust in vivo efficacy of 4l…”
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Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors by Alberati, Daniela, Ceccarelli, Simona M., Jolidon, Synèse, Krafft, Eva A., Kurt, Anke, Maier, Axel, Pinard, Emmanuel, Stalder, Henri, Studer, Deborah, Thomas, Andrew W., Zimmerli, Daniel

“…A novel class of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-ones have been discovered and developed as potent and selective GlyT1…”
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A carbonylative cross-coupling strategy to the total synthesis of the sarcodictyins: preliminary studies and synthesis of a cyclization precursor by Ceccarelli, Simona M, Piarulli, Umberto, Telser, Joachim, Gennari, Cesare

“…Preliminary studies were conducted on the implementation of a new strategy to the total synthesis of the common diterpenoid tricyclic skeleton of sarcodictyins…”
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Synthesis of a simplified sarcodictyin analogue which retains microtubule stabilising properties by Telser, Joachim, Beumer, Raphael, Bell, Andrew A, Ceccarelli, Simona M, Monti, Diego, Gennari, Cesare

“…A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15 . The precursor diene is accessed via…”
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