Search Results - "Ceccaldi, Alexandre"
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Delivering the power of nanomedicine to patients today
Published in Journal of controlled release (10-10-2020)“…The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified…”
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No effect of triheptanoin on exercise performance in McArdle disease
Published in Annals of clinical and translational neurology (01-10-2019)“…Objective To study if treatment with triheptanoin, a 7‐carbon triglyceride, improves exercise tolerance in patients with McArdle disease. McArdle patients have…”
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3
Triplex Formation on DNA Targets: How To Choose the Oligonucleotide
Published in Biochemistry (Easton) (25-11-2008)“…Triplex-forming oligonucleotides (TFOs) are sequence-specific DNA binders. TFOs provide a tool for controlling gene expression or, when attached to an…”
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Reduced Rivaroxaban Dose Versus Dual Antiplatelet Therapy After Left Atrial Appendage Closure: ADRIFT a Randomized Pilot Study
Published in Circulation. Cardiovascular interventions (01-07-2020)“…Percutaneous left atrial appendage closure (LAAC) exposes to the risk of device thrombosis in patients with atrial fibrillation who frequently have a…”
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5
Synthesis and Evaluation of Analogues of N‑Phthaloyl‑l‑tryptophan (RG108) as Inhibitors of DNA Methyltransferase 1
Published in Journal of medicinal chemistry (23-01-2014)“…DNA methyltransferases (DNMT) are promising drug targets in cancer provided that new, more specific, and chemically stable inhibitors are discovered. Among the…”
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Copeptin as a prognostic biomarker in acute myocardial infarction
Published in International journal of cardiology (01-01-2019)“…Copeptin - the C-terminal section of vasopressin precursor - is a novel biomarker, that has been shown to be a useful prognostic factor in heart failure,…”
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Altered cardiac reserve is a determinant of exercise intolerance in sickle cell anaemia patients
Published in European journal of clinical investigation (01-01-2022)“…Background The underlying mechanisms of exercise intolerance in sickle cell anaemia (SCA) patients are complex and not yet completely understood. While latent…”
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Cardiac manifestations in sickle cell disease varies with patient genotype
Published in British journal of haematology (01-06-2018)“…Summary Cardiac involvement is well characterized in sickle cell anaemia (SCA) but cardiac features associated with Haemoglobin SC (HbSC) disease are mostly…”
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Low level exercise echocardiography helps diagnose early stage heart failure with preserved ejection fraction: a study of echocardiography versus catheterization
Published in Clinical research in cardiology (01-03-2017)“…Background Increased left ventricular end-diastolic pressure (LVEDP) with exercise is an early sign of heart failure with preserved left ventricular ejection…”
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C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development
Published in Chembiochem : a European journal of chemical biology (14-06-2011)“…DNA methylation is involved in the regulation of gene expression and plays an important role in normal developmental processes and diseases, such as cancer…”
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Impact of negative inotropic drugs on accuracy of diastolic stress echocardiography for evaluation of left ventricular filling pressure
Published in Scientific reports (25-08-2017)“…The ratio of early diastolic trans-mitral flow velocity to tissue-Doppler mitral annular early diastolic velocity (E/e′), and left ventricular end-diastolic…”
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12
Reduced Rivaroxaban Dose Versus Dual Antiplatelet Therapy After Left Atrial Appendage Closure
Published in Circulation. Cardiovascular interventions (01-07-2020)“…Background: Percutaneous left atrial appendage closure (LAAC) exposes to the risk of device thrombosis in patients with atrial fibrillation who frequently have…”
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13
Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide
Published in Chembiochem : a European journal of chemical biology (02-01-2012)“…DNA methyltransferases (DNMTs) are responsible for DNA methylation, an epigenetic modification involved in gene regulation. Families of conjugates of…”
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DNA methylation associated with polycomb repression in retinoic acid receptor β silencing
Published in The FASEB journal (01-04-2013)“…Retinoic acid receptor β 2 (RARβ2) is a tumor suppressor gene whose loss of expression is recurrent in prostate cancers. Here we studied the epigenetic…”
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Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella
Published in Journal of cardiovascular translational research (01-04-2019)“…Non-invasive means of evaluating appropriate cardiac unloading remain to be established. We hypothesized that myocardial deformation assessed by…”
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Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library
Published in ACS chemical biology (15-03-2013)“…In order to discover new inhibitors of the DNA methyltransferase 3A/3L complex, we used a medium-throughput nonradioactive screen on a random collection of…”
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0147: Cardiac involvement in hemoglobin SC disease compared to homozygous sickle-cell anemia
Published in Archives of cardiovascular diseases supplements (01-01-2016)Get full text
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22 Cardiac involvement in hemoglobin SC disease compared to homozygous sickle-cell anemia
Published in Archives of cardiovascular diseases supplements (01-05-2015)Get full text
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DNA methyltransferase assays
Published in Methods in molecular biology (Clifton, N.J.) (01-01-2011)“…DNA methyltransferases are important enzymes and their inhibition has many potential applications. The investigation of DNA methyltransferases as well as…”
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Triple Helix-Forming Oligonucleotides Conjugated to New Inhibitors of Topoisomerase II: Synthesis and Binding Properties
Published in Bioconjugate chemistry (01-07-2005)“…Triplex-forming oligonucleotides (TFOs) are among the most specific DNA ligands and represent an important tool for specific regulation of gene expression…”
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