Relationship between erythrocyte catalase and serum adenosine deaminase activities in eclampsia

Relationship between erythrocyte catalase and serum adenosine deaminase activities in eclampsia

Objective. To examine the relationship between antioxidant status and T-cell activation in the pathogenesis of eclampsia by measuring the activities of erythrocyte catalase, an enzyme of antioxidant mechanism, and serum adenosine deaminase (ADA), regarded as a marker of T-cell activation. Methods. A...

Full description

Saved in:
Bibliographic Details
Published in:The journal of maternal-fetal & neonatal medicine Vol. 22; no. 4; pp. 321 - 324
Main Authors: Kolusari, Ali, Kurdoglu, Mertihan, Bugdayci, Guler, Adali, Ertan, Yildizhan, Recep, Cebi, Ay egul, Demir, Halit, Sahin, Guler, Kamaci, Mansur
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01-01-2009
Taylor & Francis
Subjects:
adenosine deaminase
Adenosine Deaminase - blood
Adolescent
Adult
Antioxidants - metabolism
catalase
Catalase - metabolism
Eclampsia
Eclampsia - blood
Eclampsia - immunology
erythrocyte
Erythrocytes - enzymology
Female
Humans
Lymphocyte Activation
Pregnancy
T-Lymphocytes - physiology
Young Adult
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. To examine the relationship between antioxidant status and T-cell activation in the pathogenesis of eclampsia by measuring the activities of erythrocyte catalase, an enzyme of antioxidant mechanism, and serum adenosine deaminase (ADA), regarded as a marker of T-cell activation. Methods. A total of 60 patients [20 eclamptic (E) pregnant women, 20 healthy pregnant (HP) women and 20 non-pregnant (NP) women] were included in the study. Maternal venous blood samples were obtained from each patient during weeks 28-37 of gestation, and biochemical analyses of catalase activity in erythrocytes and ADA activity in serum were carried out. Results. Erythrocyte catalase activity was significantly lower and serum ADA activity was significantly higher in the E pregnant women when compared with the HP women and NP women (P <0.001). No significant correlation was observed between erythrocyte catalase activity and serum ADA activity. Conclusions. Erythrocyte catalase and serum ADA activities may at least in part contribute to the pathogenesis of eclampsia. However, more studies are needed to verify and clarify the relationship between antioxidant status and T-cell activation in eclampsia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1476-7058
1476-4954
DOI:10.1080/14767050802702356