Search Results - "Cebeira, M"

Design and application of a 23-gene panel by next-generation sequencing for inherited coagulation bleeding disorders by Bastida, J. M., del Rey, M., Lozano, M. L., Sarasquete, M. E., Benito, R., Fontecha, M. E., Fisac, R., García-Frade, L. J., Aguilar, C., Martínez, M. P., Pardal, E., Aguilera, C., Pérez, B., Ramos, R., Cardesa, M. R., Martin-Antorán, J. M., Silvestre, L. A., Cebeira, M. J., Bermejo, N., Riesco, S., Mendoza, M. C., García-Sanz, R., González-Díaz, M., Hernández-Rivas, J. M., González-Porras, J. R.

“…Introduction Molecular testing of Inherited bleeding coagulation disorders (IBCDs) not only offers confirmation of diagnosis but also aids in genetic…”
Get full text

Cannabinoid tolerance and dependence: A review of studies in laboratory animals by González, Sara, Cebeira, Maribel, Fernández-Ruiz, Javier

“…Two are the issues on cannabis addiction that provoke more controversy from a research perspective. The first one is related to the development of tolerance…”
Get full text

Brain Regional Distribution of Endocannabinoids: Implications for Their Biosynthesis and Biological Function by Bisogno, T., Berrendero, F., Ambrosino, G., Cebeira, M., Ramos, J.A., Fernandez-Ruiz, J.J., Di Marzo, V.

“…The amounts, in nine different rat brain regions, of the two endocannabinoids, anandamide (arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG),…”
Get full text

Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets by Lastres-Becker, I., Cebeira, M., L. de Ceballos, M, Zeng, B. -Y., Jenner, P., Ramos, J. A., Fernández-Ruiz, J. J.

“…Recent evidence obtained in rat models of Parkinson's disease showed that the density of cannabinoid CB1 receptors and their endogenous ligands increase in…”
Get full text

Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development by Berrendero, F, García-Gil, L, Hernández, M L, Romero, J, Cebeira, M, de Miguel, R, Ramos, J A, Fernández-Ruiz, J J

“…In the present work, we analyzed cannabinoid receptor mRNA expression, binding and activation of signal transduction mechanisms in the fetal rat brain or in…”
Get full text

The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons by Romero, J, García, L, Cebeira, M, Zadrozny, D, Fernández-Ruiz, J J, Ramos, J A

“…The present study has been designed to test whether the recently described endogenous ligand for the cannabinoid receptor, arachidonylethanolamide, termed…”
Get more information

Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement by Rodríguez de Fonseca, F, Cebeira, M, Ramos, J A, Martín, M, Fernández-Ruiz, J J

“…Cannabinoid effects on brain dopaminergic activity vary as a function of gonadal status. In this work, we examined whether these variations might be due to sex…”
Get more information

Effects of pre- and perinatal exposure to hashish extracts on the ontogeny of brain dopaminergic neurons by Rodríguez de Fonseca, F, Cebeira, M, Fernández-Ruiz, J J, Navarro, M, Ramos, J A

“…The changes induced by maternal exposure to cannabinoids in the maturation of nigrostriatal, tuberoinfundibular and mesolimbic dopaminergic activities of rat…”
Get more information

Enhancement of Anandamide Formation in the Limbic Forebrain and Reduction of Endocannabinoid Contents in the Striatum of Δ9‐Tetrahydrocannabinol‐Tolerant Rats by Di Marzo, V., Berrendero, F., Bisogno, T., González, S., Cavaliere, P., Romero, J., Cebeira, M., Ramos, J. A., Fernández‐Ruiz, J. J.

“…: Recent studies have shown that the pharmacological tolerance observed after prolonged exposure to synthetic or plant‐derived cannabinoids in adult rats is…”
Get full text

Perinatal delta(9)-tetrahydrocannabinol exposure alters the responsiveness of hypothalamic dopaminergic neurons to dopamine-acting drugs in adult rats by García-Gil, L, De Miguel, R, Muñoz, R M, Cebeira, M, Villanua, M A, Ramos, J A, Fernández-Ruiz, J J

“…We have recently reported that perinatal cannabinoid exposure altered the normal development of dopaminergic neurons in the medial basal hypothalamus at early…”
Get full text

Acute effects of delta-9-tetrahydrocannabinol on dopaminergic activity in several rat brain areas by Rodríguez De Fonseca, F, Fernández-Ruiz, J J, Murphy, L L, Cebeira, M, Steger, R W, Bartke, A, Ramos, J A

“…In this work, we examined the acute effects of two doses of delta-9-tetrahydrocannabinol (THC) on several pre- and postsynaptic biochemical measures of…”
Get more information

Identification of a new potential mechanism responsible for severe bleeding in myeloma: immunoglobulins bind the heparin binding domain of antithrombin activating this endogenous anticoagulant by Martínez-Martínez, Irene, González-Porras, José Ramón, Cebeira, María José, de Arriba, Felipe, Espín, Salvador, Bohdan, Nataliya, Corrales, Fernando José, Corral, Javier, Vicente, Vicente

Get full text

Perinatal Δ9-tetrahydrocannabinol exposure alters the responsiveness of hypothalamic dopaminergic neurons to dopamine-acting drugs in adult rats by GARCA-GIL, L, DE MIGUEL, R, MUNOZ, R. M, CEBEIRA, M, VILLANUA, M. A, RAMOS, J. A, FERNANDEZ-RUIZ, J. J

Get full text

Monoclonal Gammopathy of Undetermined Significance: Predictors of Malignant Transformation and Recognition of an Evolving Type Characterized by a Progressive Increase in M Protein Size by Rosiñol, Laura, MD, Cibeira, M. Teresa, MD, Montoto, Silvia, MD, Rozman, María, MD, Esteve, Jordi, MD, Filella, Xavier, MD, Bladé, Joan, MD

“…OBJECTIVE To investigate the predictors of monoclonal gammopathy of undetermined significance (MGUS) by considering not only the initial features but also the…”
Get full text

Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to δ9-tetrahydrocannabinol by Romero, J., García, L., Fernández-Ruiz, J.J., Cebeira, M., Ramos, J.A.

“…A brain constituent, the N-amide derivative of arachidonic acid, termed anandamide, has been recently proposed as a possible endogenous ligand for the…”
Get full text

Modifications of striatal D2 dopaminergic postsynaptic sensitivity during development of morphine tolerance-dependence in mice by Navarro, M, Fernández-Ruiz, J J, Rodriguez de Fonseca, F, Hernández, M L, Cebeira, M, Ramos, J A

“…Alterations in the activity of striatal dopaminergic neurons have been implicated in the development of morphine tolerance-dependence in rodents. To further…”
Get more information

Modifications of mesolimbic and nigrostriatal dopaminergic activities after intracerebroventricular administration of prolactin by Hernández, M L, Fernández-Ruiz, J J, Navarro, M, de Miguel, R, Cebeira, M, Vaticón, L, Ramos, J A

“…In the present study we examined the effects of intracerebroventricular (i.c.v.) injections of prolactin (PRL) on the presynaptic activity and post-synaptic…”
Get full text

Possible role of dopamine and noradrenaline in the regulation of prolactin secretion from an ectopic anterior pituitary gland in female rats by Fernández-Ruiz, J J, Cebeira, M, Agrasal, C, Tresguerres, J A, Bartke, A, Esquifino, A I, Ramos, J A

“…It was recently reported that anterior pituitary tissue transplanted to an ectopic site contains measurable amounts of dopamine and noradrenaline. To examine…”
Get more information

Lack of effect of prolactin on the dopaminergic receptor sensitivity in striatal and limbic areas after experimentally-induced alterations in its peripheral levels by Cebeira, M, Hernandez, M L, Rodriguez de Fonseca, F, de Miguel, R, Fernandez-Ruiz, J J, Ramos, J A

“…Although it had been suggested that prolactin (PRL) modulates the dopaminergic receptor sensitivity in extrahypothalamic areas, recent studies have questioned…”
Get more information

Changes in endocannabinoid transmission in the basal ganglia in a rat model of Huntington's disease by Lastres-Becker, Isabel, Fezza, Filomena, Cebeira, Maribel, Bisogno, Tiziana, Ramos, José A, Milone, Alfredo, Fernández-Ruiz, Javier, Marzo, Vincenzo Di

“…Recent studies have demonstrated a loss of cannabinoid CB1 receptors in the basal ganglia in Huntington's disease (HD), but there are no data on…”
Get full text