Search Results - "Cebak, John E"
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Lipidomics biomarker studies: Errors, limitations, and the future
Published in Biochemical and biophysical research communications (07-10-2018)“…Lipidomics is an ever-expanding subfield of metabolomics that surveys 3000 to 5000 individual lipids across more than 56 lipid subclasses, including lipid…”
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Human Brain Lipidomics: Utilities of Chloride Adducts in Flow Injection Analysis
Published in Life (Basel, Switzerland) (28-04-2021)“…Ceramides have been implicated in a number of disease processes. However, current means of evaluation with flow infusion analysis (FIA) have been limited…”
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Pharmacological analysis of the cortical neuronal cytoskeletal protective efficacy of the calpain inhibitor SNJ‐1945 in a mouse traumatic brain injury model
Published in Journal of neurochemistry (01-04-2013)“…The efficacy of the amphipathic ketoamide calpain inhibitor SNJ‐1945 in attenuating calpain‐mediated degradation of the neuronal cytoskeletal protein…”
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Tear Film Amphiphilic and Anti-Inflammatory Lipids in Bovine Pink Eye
Published in Metabolites (21-11-2018)“…: Tear film fluid serves as a dynamic barrier that both lubricates the eye and protects against allergens and infectious agents. However, a detailed analysis…”
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Reduced Plasma Levels of Very-Long-Chain Dicarboxylic Acid 28:4 in Italian and Brazilian Colorectal Cancer Patient Cohorts
Published in Metabolites (06-12-2018)“…There are currently no blood-based biomarkers for early diagnosis of colorectal cancer. Previous research has suggested that very-long-chain dicarboxylic acid…”
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Newer pharmacological approaches for antioxidant neuroprotection in traumatic brain injury
Published in Neuropharmacology (01-02-2019)“…Reactive oxygen species-induced oxidative damage remains an extensively validated secondary injury mechanism in traumatic brain injury (TBI) as demonstrated by…”
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Concomitant presentation of eosinophilic or oncocytic mucoepidermoid carcinoma, immunoglobulin G4–related disease, and adult-onset asthma and periocular xanthogranuloma: Case report of 3 uncommon clinical entities
Published in Medicine (Baltimore) (12-08-2022)“…Immunoglobulin (Ig) G4-related disease (IgG4-RD) reportedly has a strong relationship with adult-onset asthma and periocular xanthogranuloma (AAPOX) and may be…”
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Phenelzine Protects Brain Mitochondrial Function In Vitro and In Vivo following Traumatic Brain Injury by Scavenging the Reactive Carbonyls 4-Hydroxynonenal and Acrolein Leading to Cortical Histological Neuroprotection
Published in Journal of neurotrauma (01-04-2017)“…Lipid peroxidation (LP) is a key contributor to the pathophysiology of traumatic brain injury (TBI). Traditional antioxidant therapies are intended to scavenge…”
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Diacylglycerols as biomarkers of sustained immune activation in Proteinopathies associated with dementia
Published in Clinica chimica acta (01-01-2018)“…Cognitive decline is a devastating clinical condition, heavily correlated with age progression. In the cases of Alzheimer's disease, Parkinson's disease, and…”
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Continuous Infusion of Phenelzine, Cyclosporine A, or Their Combination: Evaluation of Mitochondrial Bioenergetics, Oxidative Damage, and Cytoskeletal Degradation following Severe Controlled Cortical Impact Traumatic Brain Injury in Rats
Published in Journal of neurotrauma (01-06-2018)“…To date, all monotherapy clinical traumatic brain injury (TBI) trials have failed, and there are currently no Food and Drug Administration (FDA)-approved…”
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Phenelzine Mitochondrial Functional Preservation and Neuroprotection after Traumatic Brain Injury Related to Scavenging of the Lipid Peroxidation-Derived Aldehyde 4-Hydroxy-2-Nonenal
Published in Journal of cerebral blood flow and metabolism (01-04-2013)“…Phenelzine (PZ) is a scavenger of the lipid peroxidation (LP)-derived reactive aldehyde 4-hydroxynonenal (4-HNE) due to its hydrazine functional group, which…”
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