Search Results - "Cearley, Cassia"

Transduction Characteristics of Adeno-associated Virus Vectors Expressing Cap Serotypes 7, 8, 9, and Rh10 in the Mouse Brain by Cearley, Cassia N, Wolfe, John H

“…Recombinant adeno-associated viral (AAV) vectors can transduce cells of the CNS, resulting in long-term expression. AAV vector transduction varies depending on…”
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A Single Injection of an Adeno-Associated Virus Vector into Nuclei with Divergent Connections Results in Widespread Vector Distribution in the Brain and Global Correction of a Neurogenetic Disease by Cearley, Cassia N, Wolfe, John H

“…Neurogenetic disorders typically affect cells throughout the brain. Adeno-associated virus (AAV) vector-mediated transfer of a normal cDNA can correct the…”
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Rat ultrasonic vocalizations as a measure of the emotional component of chronic pain by Burgdorf, Jeffrey S, Ghoreishi-Haack, Nayereh, Cearley, Cassia N, Kroes, Roger A, Moskal, Joseph R

“…In humans, chronic pain is often expressed as a spontaneous emotional response which can lead to fragmented sleep. Rat 50-kHz and 20-kHz ultrasonic…”
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Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology by Parente, Michael K, Rozen, Ramona, Cearley, Cassia N, Wolfe, John H

“…The characteristic neurological feature of many neurogenetic diseases is intellectual disability. Although specific neuropathological features have been…”
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Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey by Vandenberghe, Luk H, Bell, Peter, Maguire, Albert M, Cearley, Cassia N, Xiao, Ru, Calcedo, Roberto, Wang, Lili, Castle, Michael J, Maguire, Alexandra C, Grant, Rebecca, Wolfe, John H, Wilson, James M, Bennett, Jean

“…Gene therapy is emerging as a therapeutic modality for treating disorders of the retina. Photoreceptor cells are the primary cell type affected in many…”
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NYX‐458 Improves Cognitive Performance in a Primate Parkinson's Disease Model by Barth, A.L, Schneider, J.S., Johnston, T.H., Hill, M.P., Brotchie, J.M., Moskal, J.R., Cearley, Cassia N.

“…BACKGROUND NYX‐458 is a N‐methyl‐d‐aspartate receptor (NMDAR) modulator that enhances synaptic plasticity. Dopaminergic cell loss in Parkinson's disease (PD)…”
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Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain by Cearley, Cassia N, Vandenberghe, Luk H, Parente, Michael K, Carnish, Erin R, Wilson, James M, Wolfe, John H

“…A wide diversity of adeno-associated virus (AAV) structural proteins uncovered from latent genomes in primate tissue has expanded the number of AAV vector…”
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NYX-2925 Is a Novel N -Methyl-d-Aspartate Receptor Modulator that Induces Rapid and Long-Lasting Analgesia in Rat Models of Neuropathic Pain by Ghoreishi-Haack, Nayereh, Priebe, Jessica M, Aguado, Jacqueline D, Colechio, Elizabeth M, Burgdorf, Jeffrey S, Bowers, M Scott, Cearley, Cassia N, Khan, M Amin, Moskal, Joseph R

“…NYX-2925 [(2S,3R)-3-hydroxy-2-((R)-5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide] is a novel -methyl-d-aspartate (NMDA) receptor modulator that…”
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Acute Cocaine Increases Interleukin-1β mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens by Cearley, Cassia N., Blindheim, Kelly, Sorg, Barbara A., Krueger, James M., Churchill, Lynn

“…The cytokine, interleukin-1β (IL1β) is a sleep regulatory substance whose expression is enhanced in response to neuronal stimulation. In this study, IL1β mRNA…”
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The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC by Morrison, Gladys, Asiedu, Marina N., Priebe, Jessica M., Dunning, Jacqueline, Ghoreishi-Haack, Nayereh, Kroes, Roger A., Bowers, M. Scott, Barth, Amanda L., Cearley, Cassia N., Moskal, Joseph R.

“…•Direct injection of the NMDAR modulator NYX-2925 in the mPFC, reverses allodynia.•Src activity is downregulated in the mPFC of a CCI neuropathic pain…”
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899. Utilizing the Vector Transport Properties of AAV-9 as a Method To Get Widespread Distribution of a Therapeutic Gene within the CNS by Cearley, Cassia N., Wolfe, John H.

“…The use of gene therapy to treat disorders of the central nervous system has been limited due to the invasiveness of the multiple injections needed for…”
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NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory by Khan, M Amin, Houck, David R, Gross, Amanda L, Zhang, Xiao-Lei, Cearley, Cassia, Madsen, Torsten M, Kroes, Roger A, Stanton, Patric K, Burgdorf, Jeffrey, Moskal, Joseph R

“…N-methyl-D-aspartate receptors are one member of a family of ionotropic glutamate receptors that play a pivotal role in synaptic plasticity processes…”
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NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-[beta]-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory by Khan, M. Amin, Houck, David R, Gross, Amanda L, Zhang, Xiao-lei, Cearley, Cassia, Madsen, Torsten M, Kroes, Roger A, Stanton, Patric K, Burgdorf, Jeffrey, Moskal, Joseph R

“…Background: N-methyl-D-aspartate receptors are one member of a family of ionotropic glutamate receptors that play a pivotal role in synaptic plasticity…”
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Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1β or tumor necrosis factor α by Churchill, Lynn, Taishi, Ping, Wang, Mingfei, Brandt, Judith, Cearley, Cassia, Rehman, Abdur, Krueger, James M.

“…Brain cytokine mRNA levels are impacted by systemic cytokines. For example, systemic interleukin-1β (IL1β) increases brain IL1β mRNA; subdiaphragmatic vagotomy…”
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Acute Cocaine Increases Interleukin-1I2 mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens by Cearley, Cassia N, Blindheim, Kelly, Sorg, Barbara A, Krueger, James M, Churchill, Lynn

“…The cytokine, interleukin-1I2 (IL1I2) is a sleep regulatory substance whose expression is enhanced in response to neuronal stimulation. In this study, IL1I2…”
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Acute Cocaine Increases Interleukin-1[beta] mRNA and Immunoreactive Cells in the Cortex and Nucleus Accumbens by Cearley, Cassia N, Blindheim, Kelly, Sorg, Barbara A, Krueger, James M, Churchill, Lynn

“…Issue Title: Special Issue: In Honor of Dr. Dianna Johnson The cytokine, interleukin-1β (IL1β) is a sleep regulatory substance whose expression is enhanced in…”
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Time of day differences in IL1β and TNFα mRNA levels in specific regions of the rat brain by Cearley, Cassia, Churchill, Lynn, Krueger, James M.

“…Interleukin-1β (IL1β) and tumor necrosis factor-α (TNFα) are involved in several physiological functions regulated by brain. The current studies were performed…”
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Time of day differences in IL1beta and TNFalpha mRNA levels in specific regions of the rat brain by Cearley, Cassia, Churchill, Lynn, Krueger, James M

“…Interleukin-1beta (IL1beta) and tumor necrosis factor-alpha (TNFalpha) are involved in several physiological functions regulated by brain. The current studies…”
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Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1beta or tumor necrosis factor alpha by Churchill, Lynn, Taishi, Ping, Wang, Mingfei, Brandt, Judith, Cearley, Cassia, Rehman, Abdur, Krueger, James M

“…Brain cytokine mRNA levels are impacted by systemic cytokines. For example, systemic interleukin-1beta (IL1beta) increases brain IL1beta mRNA; subdiaphragmatic…”
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Time of day differences in IL1β and TNFα mRNA levels in specific regions of the rat brain by CEARLEY, Cassia, CHURCHILL, Lynn, KRUEGER, James M

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