Search Results - "Ceña‐Díez, Rafael"

Mechanistic Studies of Viral Entry: An Overview of Dendrimer‐Based Microbicides As Entry Inhibitors Against Both HIV and HSV‐2 Overlapped Infections by Sepúlveda‐Crespo, Daniel, Ceña‐Díez, Rafael, Jiménez, José Luis, Ángeles Muñoz‐Fernández, Ma

“…This review provides an overview of the development of different dendrimers, mainly polyanionic, against human immunodeficiency virus (HIV) and genital herpes…”
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Broad synergistic antiviral efficacy between a novel elite controller-derived dipeptide and antiretrovirals against drug-resistant HIV-1 by Giammarino, Federica, Sönnerborg, Anders, Ceña-Diez, Rafael

“…The naturally occurring dipeptide Tryptophylglycine (WG) is enhanced in human immunodeficiency virus (HIV-1) infected Elite Controllers (EC). We have shown…”
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Fecal Metabolome Signature in the HIV-1 Elite Control Phenotype: Enrichment of Dipeptides Acts as an HIV-1 Antagonist but a Prevotella Agonist by Sperk, Maike, Ambikan, Anoop T, Ray, Shilpa, Singh, Kamal, Mikaeloff, Flora, Diez, Rafael Ceña, Narayanan, Ashwathy, Vesterbacka, Jan, Nowak, Piotr, Sönnerborg, Anders, Neogi, Ujjwal

“…HIV-1 elite controllers (EC) are a rare group among HIV-1-infected individuals who can naturally control viral replication for a prolonged period. Due to their…”
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Safety of G2-S16 Polyanionic Carbosilane Dendrimer as Possible HIV-1 Vaginal Microbicide by Martin-Moreno, Alba, Ceña-Diez, Rafael, Serramía, María Jesús, Jiménez, José Luis, Gómez-Ramírez, Rafael, Muñoz-Fernández, Mariángeles

“…The UNAIDS objective for 2020 was 500,000 new HIV-1 infections per year; however, the latest annual reported data confirmed 1.7 million new HIV-1 infections in…”
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Synthetic Mucin Gels with Self‐Healing Properties Augment Lubricity and Inhibit HIV‐1 and HSV‐2 Transmission by Kretschmer, Martin, Ceña‐Diez, Rafael, Butnarasu, Cosmin, Silveira, Valentin, Dobryden, Illia, Visentin, Sonja, Berglund, Per, Sönnerborg, Anders, Lieleg, Oliver, Crouzier, Thomas, Yan, Hongji

“…Mucus is a self‐healing gel that lubricates the moist epithelium and provides protection against viruses by binding to viruses smaller than the gel's mesh size…”
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Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action by Ceña-Diez, Rafael, Vacas-Córdoba, Enrique, García-Broncano, Pilar, de la Mata, F J, Gómez, Rafael, Maly, Marek, Muñoz-Fernández, M Ángeles

“…Topical microbicides to stop sexually transmitted diseases, such as herpes simplex virus type 2 (HSV-2), are urgently needed. The emerging field of…”
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Role of G2-S16 Polyanionic Carbosilane Dendrimer in the Prevention of Respiratory Syncytial Virus Infection In Vitro and In Vivo in Mice by Rodriguez-Izquierdo, Ignacio, Ceña-Diez, Rafael, Serramia, Maria Jesús, Rodriguez-Fernández, Rosa, Martínez, Isidoro, Muñoz-Fernández, Mariángeles

“…The respiratory syncytial virus (RSV) causes respiratory infection and bronchiolitis, requiring hospitalization mainly in infants. The interaction between RSV,…”
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Efficacy of HIV antiviral polyanionic carbosilane dendrimer G2-S16 in the presence of semen by Ceña-Diez, Rafael, García-Broncano, Pilar, de la Mata, Francisco Javier, Gómez, Rafael, Muñoz-Fernández, M Ángeles

“…The development of a safe and effective microbicide to prevent the sexual transmission of human immunodeficiency virus (HIV)-1 is urgently needed…”
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Characterization of the Upper Respiratory Bacterial Microbiome in Critically Ill COVID-19 Patients by Bai, Xiangning, Narayanan, Aswathy, Skagerberg, Magdalena, Ceña-Diez, Rafael, Giske, Christian G, Strålin, Kristoffer, Sönnerborg, Anders

“…The upper respiratory tract (URT) microbiome can contribute to the acquisition and severity of respiratory viral infections. The described associations between…”
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Cationic Dendrimer G2-S16 Inhibits Herpes Simplex Type 2 Infection and Protects Mice Vaginal Microbiome by Guerrero-Beltrán, Carlos, Garcia-Heredia, Inmaculada, Ceña-Diez, Rafael, Rodriguez-Izquierdo, Ignacio, Serramía, María Jesús, Martinez-Hernandez, Francisco, Lluesma-Gomez, Mónica, Martinez-Garcia, Manuel, Muñoz-Fernández, María Ángeles

“…The G2-S16 polyanionic carbosilane dendrimer is a promising microbicide that inhibits HSV-2 infection in vitro and in vivo in mice models. This G2-S16…”
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Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections: MECHANISTIC STUDIES OF VIRAL ENTRY by Sepúlveda-Crespo, Daniel, Ceña-Díez, Rafael, Jiménez, José Luis, Ángeles Muñoz-Fernández, Ma

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Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide by Ceña-Diez, Rafael, Spetz, Anna-Lena, Sönnerborg, Anders

“…The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-am:ssON) showed synergistic antiviral activity against HIV-1 integrase-,…”
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New anionic poly(alkylideneamine) dendrimers as microbicide agents against HIV-1 infection by Maciel, Dina, Guerrero-Beltrán, Carlos, Ceña-Diez, Rafael, Tomás, Helena, Muñoz-Fernández, M Ángeles, Rodrigues, João

“…Acquired immune deficiency syndrome (AIDS) due to human immunodeficiency virus type-1 (HIV-1) represents one of the most important sexually transmitted…”
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Efficacy of carbosilane dendrimers with an antiretroviral combination against HIV-1 in the presence of semen-derived enhancer of viral infection by García-Broncano, Pilar, Ceña-Diez, Rafael, de la Mata, Francisco J., Gómez, Rafael, Resino, Salvador, Muñoz-Fernández, M. Ángeles

“…Amyloid fibrils, which are present in semen, were considered to be a cause of topical vaginal gel ineffectiveness in vivo after microbicides failed as HIV-1…”
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G2-S16 dendrimer as a candidate for a microbicide to prevent HIV-1 infection in women by Ceña-Diez, Rafael, García-Broncano, Pilar, Javier de la Mata, Francisco, Gómez, Rafael, Resino, Salvador, Muñoz-Fernández, MªÁngeles

“…Unprotected heterosexual intercourse is the first route for sustaining the global spread of human immunodeficiency virus type 1 (HIV-1), being responsible for…”
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Naturally occurring dipeptide from elite controllers with dual anti-HIV-1 mechanism by Ceña-Diez, Rafael, Narayanan, Aswathy, Ray, Shilpa, van de Klundert, Maarten, Rodriguez, Jimmy E, Nilvebrant, Johan, Nygren, Per-Åke, Végvári, Ákos, van Domselaar, Robert, Sönnerborg, Anders

“…•WG-am is a naturally occurring dipeptide from elite controllers with anti-HIV activity.•WG-am is a new antiviral compound with two independent mechanisms of…”
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G1-S4 or G2-S16 carbosilane dendrimer in combination with Platycodin D as a promising vaginal microbicide candidate with contraceptive activity by Ceña-Diez, Rafael, Martin-Moreno, Alba, de la Mata, F Javier, Gómez-Ramirez, Rafael, Muñoz, Eduardo, Ardoy, Manuel, Muñoz-Fernández, Ma Ángeles

“…HIV-1 and herpes simplex virus type-2 (HSV-2) represent two of the most relevant sexually transmitted diseases (STDs) worldwide. Moreover, each year there are…”
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Molecular Epidemiology of HIV-1 in Eastern Europe and Russia by van de Klundert, Maarten A. A., Antonova, Anastasiia, Di Teodoro, Giulia, Ceña Diez, Rafael, Chkhartishvili, Nikoloz, Heger, Eva, Kuznetsova, Anna, Lebedev, Aleksey, Narayanan, Aswathy, Ozhmegova, Ekaterina, Pronin, Alexander, Shemshura, Andrey, Tumanov, Alexandr, Pfeifer, Nico, Kaiser, Rolf, Saladini, Francesco, Zazzi, Maurizio, Incardona, Francesca, Bobkova, Marina, Sönnerborg, Anders

“…The HIV epidemic in Eastern Europe and Russia is large and not well-controlled. To describe the more recent molecular epidemiology of HIV-1, transmitted drug…”
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Novel Naturally Occurring Dipeptides and Single-Stranded Oligonucleotide Act as Entry Inhibitors and Exhibit a Strong Synergistic Anti-HIV-1 Profile by Ceña-Diez, Rafael, Singh, Kamalendra, Spetz, Anna-Lena, Sönnerborg, Anders

“…Introduction The availability of new classes of antiretroviral drugs is critical for treatment-experienced patients due to drug resistance to and unwanted side…”
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New synthetic procedure for the antiviral sulfonate carbosilane dendrimer G2-S16 and its fluorescein-labelled derivative for biological studies by Gutiérrez-Ulloa, Carlos, Peña-González, Cornelia E, Barrios-Gumiel, Andrea, Ceña-Díez, Rafael, Serramía-Lobera, M. Jesús, Muñoz-Fernández, M. Ángeles, Javier de la Mata, F, Sánchez-Nieves, Javier, Gómez, Rafael

“…The anionic carbosilane (CBS) dendrimer with sulfonate groups G2-S16 is a promising compound for the preparation of a microbicide gel to prevent HIV infection…”
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