Search Results - "Cazzulo, Juan Jose"

Transketolase from Leishmania mexicana has a dual subcellular localization by Veitch, Nicola J, Maugeri, Dante A, Cazzulo, Juan Jose, Lindqvist, Ylva, Barrett, Michael P

“…Transketolase has been characterized in Leishmania mexicana. A gene encoding this enzyme was identified and cloned. The gene was expressed in Escherichia coli…”
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Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity by Pérez, Brian, Bouvier, León A, Cazzulo, Juan José, Agüero, Fernán, Salas-Sarduy, Emir, Alvarez, Vanina E

“…A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development…”
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Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes by Salas-Sarduy, Emir, Landaburu, Lionel Urán, Karpiak, Joel, Madauss, Kevin P., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina Eder

“…American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite…”
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DNA‐damage inducible protein 1 is a conserved metacaspase substrate that is cleaved and further destabilized in yeast under specific metabolic conditions by Bouvier, León A., Niemirowicz, Gabriela T., Salas‐Sarduy, Emir, Cazzulo, Juan José, Alvarez, Vanina E.

“…Metacaspases, distant relatives of metazoan caspases, have been shown to participate in programmed cell death in plants and in progression of the cell cycle…”
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Structure, kinetic characterization and subcellular localization of the two ribulose 5-phosphate epimerase isoenzymes from Trypanosoma cruzi by Gonzalez, Soledad Natalia, Valsecchi, Wanda Mariela, Maugeri, Dante, Delfino, José María, Cazzulo, Juan José

“…The enzyme of the pentose phosphate pathway (PPP) ribulose-5-phosphate-epimerase (RPE) is encoded by two genes present in the genome of Trypanosoma cruzi CL…”
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Target-based Screening of the Chagas Box: Setting Up Enzymatic Assays to Discover Specific Inhibitors Across Bioactive Compounds by Salas-Sarduy, Emir, Niemirowicz, Gabriela T, José Cazzulo, Juan, Alvarez, Vanina E

“…Chagas disease is a neglected tropical illness caused by the protozoan parasite Trypanosoma cruzi. The disease is endemic in Latin America with about 6 million…”
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Update on relevant trypanosome peptidases: Validated targets and future challenges by Alvarez, Vanina E., Iribarren, Paula A., Niemirowicz, Gabriela T., Cazzulo, Juan José

“…Trypanosoma cruzi, the agent of the American Trypanosomiasis, Chagas disease, and Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense, the agents…”
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The glucose-6-phosphate dehydrogenase from Trypanosoma cruzi: Its role in the defense of the parasite against oxidative stress by Igoillo-Esteve, Mariana, Cazzulo, Juan José

“…The Trypanosoma cruzi glucose-6-phosphate dehydrogenase (G6PDH) is encoded by several genes located in three of the parasite chromosomes. All the sequences…”
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Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes by Salas-Sarduy, Emir, Landaburu, Lionel Urán, Carmona, Adriana K, Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina E, Niemirowicz, Gabriela T

“…Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including…”
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Biosynthesis of SUMOylated Proteins in Bacteria Using the Trypanosoma brucei Enzymatic System by Iribarren, Paula Ana, Berazategui, María Agustina, Cazzulo, Juan José, Alvarez, Vanina Eder

“…Post-translational modification with the Small Ubiquitin-like Modifier (SUMO) is conserved in eukaryotic organisms and plays important regulatory roles in…”
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Effects of proteinase inhibitors on the growth and differentiation of Trypanosoma cruzi by Franke de Cazzulo, B M, Martínez, J, North, M J, Coombs, G H, Cazzulo, J J

“…Three proteinase inhibitors, one peptidyl acyloxymethyl ketone (AMK), Z-Phe-Lys-CH2-OCO-(2,4,6-Me3)Ph.HCl, and two diazomethyl ketones (DMKs), Z-Phe-Phe-DMK…”
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All Trypanosoma cruzi developmental forms present lysosome-related organelles by Sant’Anna, Celso, Parussini, Fabiola, Lourenço, Daniela, de Souza, Wanderley, Cazzulo, Juan Jose, Cunha-e-Silva, Narcisa Leal

“…Trypanosoma cruzi epimastigote forms concentrate their major protease, cruzipain, in the same compartment where these parasites store macromolecules obtained…”
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Glucose metabolism in Trypanosoma cruzi by Maugeri, Dante A, Cannata, Joaquin J B, Cazzulo, Juan-José

“…The causative agent of Chagas disease, Trypanosoma cruzi, metabolizes glucose through two major pathways: glycolysis and the pentose phosphate pathway. Glucose…”
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Design, synthesis, and evaluation of substrate – analogue inhibitors of Trypanosoma cruzi ribose 5-phosphate isomerase type B by Gonzalez, Soledad Natalia, Mills, Jonathan J., Maugeri, Dante, Olaya, Christopher, Laguera, Breana L., Enders, Jeffrey R., Sherman, Julian, Rodriguez, Ana, Pierce, Joshua G., Cazzulo, Juan José, D'Antonio, Edward L.

“…[Display omitted] Ribose 5-phosphate isomerase type B (RPI-B) is a key enzyme of the pentose phosphate pathway that catalyzes the isomerization of ribose…”
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Analysis of the cysteine proteinases of Leishmania mexicana and Trypanosoma cruzi using specific antisera by Robertson, C D, Martinez, J, Cazzulo, J J, Coombs, G H

“…Antisera raised against papain and cysteine proteinases (CPs) purified from Leishmania mexicana and Trypanosoma cruzi have been used to study the proteins in…”
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Substrate specificity profiling of M32 metallocarboxypeptidases from Trypanosoma cruzi and Trypanosoma brucei by Frasch, Alejandra P., Bouvier, León A., Oppenheimer, Florencia M., Juliano, Maria Aparecida, Juliano, Luiz, Carmona, Adriana K., Cazzulo, Juan José, Niemirowicz, Gabriela T.

“…Positional scanning synthetic combinatorial FRET peptide libraries were used to determine the substrate specificity of two trypanosomatid M32…”
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Antiparasitic effect of a fraction enriched in tight-binding protease inhibitors isolated from the Caribbean coral Plexaura homomalla by Salas-Sarduy, Emir, Cabrera-Muñoz, Aymara, Cauerhff, Ana, González-González, Yamile, Trejo, Sebastián A., Chidichimo, Agustina, Chávez-Planes, Maria de los Angeles, Cazzulo, Juan José

“…•Plexaura homomalla extract inhibits Cruzipain and Falcipain 2 in the nanomolar range.•An inhibitor-enriched fraction is active against cysteine(CP) and…”
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The 6-phosphogluconate dehydrogenase of Leishmania (Leishmania) mexicana: gene characterization and protein structure prediction by González, Deyanira, Pérez, José Luis, Serrano, María Luisa, Igoillo-Esteve, Mariana, Cazzulo, Juan José, Barrett, Michael P, Bubis, José, Mendoza-León, Alexis

“…6-Phosphogluconate dehydrogenase (6PGDH) is a key enzyme of the oxidative branch involved in the generation of NADPH and ribulose 5-phosphate. In the present…”
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The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease by Jose Cazzulo, J, Stoka, V, Turk, V

“…Trypanosoma cruzi, the causative agent of the American Trypanosomiasis, Chagas disease, contains a major cysteine proteinase (CP), cruzipain (also known as…”
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Biosynthesis of SUMOylated Proteins in Bacteria Using the Trypanosoma brucei Enzymatic System: e0134950 by Iribarren, Paula Ana, Berazategui, Maria Agustina, Cazzulo, Juan Jose, Alvarez, Vanina Eder

“…Post-translational modification with the Small Ubiquitin-like Modifier (SUMO) is conserved in eukaryotic organisms and plays important regulatory roles in…”
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