Search Results - "Cazzaniga, Gianni"

High-Throughput Immunogenetics for Clinical and Research Applications in Immunohematology: Potential and Challenges by Langerak, Anton W, Brüggemann, Monika, Davi, Frédéric, Darzentas, Nikos, van Dongen, Jacques J M, Gonzalez, David, Cazzaniga, Gianni, Giudicelli, Véronique, Lefranc, Marie-Paule, Giraud, Mathieu, Macintyre, Elizabeth A, Hummel, Michael, Pott, Christiane, Groenen, Patricia J T A, Stamatopoulos, Kostas

“…Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-throughput way have their limitations in terms of resolution, coverage,…”
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Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis by Agraz-Doblas, Antonio, Bueno, Clara, Bashford-Rogers, Rachael, Roy, Anindita, Schneider, Pauline, Bardini, Michela, Ballerini, Paola, Cazzaniga, Gianni, Moreno, Thaidy, Revilla, Carlos, Gut, Marta, Valsecchi, Maria G, Roberts, Irene, Pieters, Rob, De Lorenzo, Paola, Varela, Ignacio, Menendez, Pablo, Stam, Ronald W

“…B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients…”
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Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions by Meyer, Claus, Lopes, Bruno A., Caye-Eude, Aurélie, Cavé, Hélène, Arfeuille, Chloé, Cuccuini, Wendy, Sutton, Rosemary, Venn, Nicola C., Oh, Seung Hwan, Tsaur, Grigory, Escherich, Gabriele, Feuchtinger, Tobias, Kosasih, Hansen J., Khaw, Seong L., Ekert, Paul G., Pombo-de-Oliveira, Maria S., Bidet, Audrey, Djahanschiri, Bardya, Ebersberger, Ingo, Zaliova, Marketa, Zuna, Jan, Zermanova, Zuzana, Juvonen, Vesa, Grümayer, Renate Panzer, Fazio, Grazia, Cazzaniga, Gianni, Larghero, Patrizia, Emerenciano, Mariana, Marschalek, Rolf

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Absent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency by Saettini, Francesco, Poli, Cecilia, Vengoechea, Jaime, Bonanomi, Sonia, Orellana, Julio C., Fazio, Grazia, Rodriguez, Fred H., Noguera, Loreani P., Booth, Claire, Jarur-Chamy, Valentina, Shams, Marissa, Iascone, Maria, Vukic, Maja, Gasperini, Serena, Quadri, Manuel, Barroeta Seijas, Amairelys, Rivers, Elizabeth, Mauri, Mario, Badolato, Raffaele, Cazzaniga, Gianni, Bugarin, Cristina, Gaipa, Giuseppe, Kroes, Wilma G.M., Moratto, Daniele, van Oostaijen-ten Dam, Monique M., Baas, Frank, van der Maarel, Silvère, Piazza, Rocco, Coban-Akdemir, Zeynep H., Lupski, James R., Yuan, Bo, Chinn, Ivan K., Daxinger, Lucia, Biondi, Andrea

“…Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3…”
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HDAC6 inhibition decreases leukemic stem cell expansion driven by Hedgehog hyperactivation by restoring primary ciliogenesis by Pezzotta, Alex, Gentile, Ilaria, Genovese, Donatella, Totaro, Maria Grazia, Battaglia, Cristina, Leung, Anskar Yu-Hung, Fumagalli, Monica, Parma, Matteo, Cazzaniga, Gianni, Fazio, Grazia, Alcalay, Myriam, Marozzi, Anna, Pistocchi, Anna

“…Aberrant activation of the Hh pathway promotes cell proliferation and multi-drug resistance (MDR) in several cancers, including Acute Myeloid Leukemia (AML)…”
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Randomized post-induction and delayed intensification therapy in high-risk pediatric acute lymphoblastic leukemia: long-term results of the international AIEOP-BFM ALL 2000 trial by Attarbaschi, Andishe, Mann, Georg, Zimmermann, Martin, Bader, Peter, Barisone, Elena, Basso, Giuseppe, Biondi, Andrea, Cario, Gunnar, Cazzaniga, Gianni, Colombini, Antonella, Flotho, Christian, Kuhlen, Michaela, Lang, Peter, Lauten, Melchior, Linderkamp, Christin, Locatelli, Franco, Lo Nigro, Luca, Möricke, Anja, Niggli, Felix, Panzer-Grümayer, Renate, Parasole, Rosanna, Peters, Christina, Caterina Putti, Maria, Rizzari, Carmelo, Suttorp, Meinolf, Valsecchi, Maria Grazia, Conter, Valentino, Schrappe, Martin

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Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols by Cario, Gunnar, Leoni, Veronica, Conter, Valentino, Attarbaschi, Andishe, Zaliova, Marketa, Sramkova, Lucie, Cazzaniga, Gianni, Fazio, Grazia, Sutton, Rosemary, Elitzur, Sarah, Izraeli, Shai, Lauten, Melchior, Locatelli, Franco, Basso, Giuseppe, Buldini, Barbara, Bergmann, Anke K, Lentes, Jana, Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte, Haas, Oskar A, Schewe, Denis, Buchmann, Swantje, Moericke, Anja, White, Deborah, Revesz, Tamas, Stanulla, Martin, Mann, Georg, Bodmer, Nicole, Arad-Cohen, Nira, Zuna, Jan, Valsecchi, Maria Grazia, Zimmermann, Martin, Schrappe, Martin, Biondi, Andrea

“…ABL-class fusions other than characterize around 2-3% of precursor B-cell acute lymphoblastic leukemia. Case series indicated that patients suffering from…”
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Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts by Chiaretti, Sabina, Vitale, Antonella, Cazzaniga, Gianni, Orlando, Sonia Maria, Silvestri, Daniela, Fazi, Paola, Valsecchi, Maria Grazia, Elia, Loredana, Testi, Anna Maria, Mancini, Francesca, Conter, Valentino, te Kronnie, Geertruy, Ferrara, Felicetto, Di Raimondo, Francesco, Tedeschi, Alessandra, Fioritoni, Giuseppe, Fabbiano, Francesco, Meloni, Giovanna, Specchia, Giorgina, Pizzolo, Giovanni, Mandelli, Franco, Guarini, Anna, Basso, Giuseppe, Biondi, Andrea, Foà, Robin

“…The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of…”
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NIPBL : a new player in myeloid cell differentiation by Mazzola, Mara, Deflorian, Gianluca, Pezzotta, Alex, Ferrari, Laura, Fazio, Grazia, Bresciani, Erica, Saitta, Claudia, Ferrari, Luca, Fumagalli, Monica, Parma, Matteo, Marasca, Federica, Bodega, Beatrice, Riva, Paola, Cotelli, Franco, Biondi, Andrea, Marozzi, Anna, Cazzaniga, Gianni, Pistocchi, Anna

“…The nucleophosmin 1 gene ( ) is the most frequently mutated gene in acute myeloid leukemia. Notably, mutations are always accompanied by additional mutations…”
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Antibody Deficiency in Patients with Biallelic KARS1 Mutations by Saettini, Francesco, Guerra, Fabiola, Fazio, Grazia, Bugarin, Cristina, McMillan, Hugh J, Ohtake, Akira, Ardissone, Anna, Itoh, Masayuki, Giglio, Sabrina, Cappuccio, Gerarda, Giardino, Giuliana, Romano, Roberta, Quadri, Manuel, Gasperini, Serena, Moratto, Daniele, Chiarini, Marco, Akira, Ishiguro, Fukuhara, Yasuyuki, Hayakawa, Itaru, Okazaki, Yasushi, Mauri, Mario, Piazza, Rocco, Cazzaniga, Gianni, Biondi, Andrea

“…Biallelic KARS1 mutations cause KARS-related diseases, a rare syndromic condition encompassing central and peripheral nervous system impairment, heart and…”
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Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4 + Infant ALL by Bardini, Michela, Trentin, Luca, Rizzo, Francesca, Vieri, Margherita, Savino, Angela M, Garrido Castro, Patricia, Fazio, Grazia, Van Roon, Eddy H J, Kerstjens, Mark, Smithers, Nicholas, Prinjha, Rab K, Te Kronnie, Geertruy, Basso, Giuseppe, Stam, Ronald W, Pieters, Rob, Biondi, Andrea, Cazzaniga, Gianni

“…-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis…”
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More precisely defining risk peri-HCT in pediatric ALL: pre- vs post-MRD measures, serial positivity, and risk modeling by Bader, Peter, Salzmann-Manrique, Emilia, Balduzzi, Adriana, Dalle, Jean-Hugues, Woolfrey, Ann E., Bar, Merav, Verneris, Michael R., Borowitz, Michael J., Shah, Nirali N., Gossai, Nathan, Shaw, Peter J., Chen, Allen R., Schultz, Kirk R., Kreyenberg, Hermann, Di Maio, Lucia, Cazzaniga, Gianni, Eckert, Cornelia, van der Velden, Vincent H.J., Sutton, Rosemary, Lankester, Arjan, Peters, Christina, Klingebiel, Thomas E., Willasch, Andre M., Grupp, Stephan A., Pulsipher, Michael A.

“…Detection of minimal residual disease (MRD) pre– and post–hematopoietic cell transplantation (HCT) for pediatric acute lymphoblastic leukemia (ALL) has been…”
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Recurrent Germline Variant in RAD21 Predisposes Children to Lymphoblastic Leukemia or Lymphoma by Schedel, Anne, Friedrich, Ulrike Anne, Morcos, Mina N F, Wagener, Rabea, Mehtonen, Juha, Watrin, Titus, Saitta, Claudia, Brozou, Triantafyllia, Michler, Pia, Walter, Carolin, Försti, Asta, Baksi, Arka, Menzel, Maria, Horak, Peter, Paramasivam, Nagarajan, Fazio, Grazia, Autry, Robert J, Fröhling, Stefan, Suttorp, Meinolf, Gertzen, Christoph, Gohlke, Holger, Bhatia, Sanil, Wadt, Karin, Schmiegelow, Kjeld, Dugas, Martin, Richter, Daniela, Glimm, Hanno, Heinäniemi, Merja, Jessberger, Rolf, Cazzaniga, Gianni, Borkhardt, Arndt, Hauer, Julia, Auer, Franziska

“…Somatic loss of function mutations in cohesin genes are frequently associated with various cancer types, while cohesin disruption in the germline causes…”
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P1056: NEXT GENERATION SEQUENCING IDENTIFIES SUBGROUPS OF PATIENTS WITH TRIPLE NEGATIVE/ PRIMARY THROMBOCYTOSIS WITH DIFFERENT CLINICAL OUTCOMES by Sangiorgio, Valentina, Giovanni Piazza, Rocco, Mottadelli, Federica, Pagni, Fabio, Elena, Inzoli, Gambacorti‐Passerini, Carlo, Cazzaniga, Gianni, Maria Elli, Elena

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The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia by Casolaro, Alessia, Golay, Josee, Albanese, Clara, Ceruti, Roberta, Patton, Veronica, Cribioli, Sabrina, Pezzoni, Alice, Losa, Marco, Texido, Gemma, Giussani, Ursula, Marchesi, Francesco, Amboldi, Nadia, Valsasina, Barbara, Bungaro, Silvia, Cazzaniga, Gianni, Rambaldi, Alessandro, Introna, Martino, Pesenti, Enrico, Alzani, Rachele

“…CD56 is expressed in 15-20% of acute myeloid leukaemias (AML) and is associated with extramedullary diffusion, multidrug resistance and poor prognosis. We…”
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Clinical features and outcome of SIL/TAL1-positive T-cell acute lymphoblastic leukemia in children and adolescents: a 10-year experience of the AIEOP group by D'Angiò, Mariella, Valsecchi, Maria G, Testi, Anna M, Conter, Valentino, Nunes, Vittorio, Parasole, Rosanna, Colombini, Antonella, Santoro, Nicola, Varotto, Stefania, Caniglia, Maurizio, Silvestri, Daniela, Consarino, Caterina, Levati, Laura, Magrin, Elisa, Locatelli, Franco, Basso, Giuseppe, Foà, Robin, Biondi, Andrea, Cazzaniga, Gianni

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Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency by Muñoz-López, Alvaro, Romero-Moya, Damià, Prieto, Cristina, Ramos-Mejía, Verónica, Agraz-Doblas, Antonio, Varela, Ignacio, Buschbeck, Marcus, Palau, Anna, Carvajal-Vergara, Xonia, Giorgetti, Alessandra, Ford, Anthony, Lako, Majlinda, Granada, Isabel, Ruiz-Xivillé, Neus, Rodríguez-Perales, Sandra, Torres-Ruíz, Raul, Stam, Ronald W., Fuster, Jose Luis, Fraga, Mario F., Nakanishi, Mahito, Cazzaniga, Gianni, Bardini, Michela, Cobo, Isabel, Bayon, Gustavo F., Fernandez, Agustin F., Bueno, Clara, Menendez, Pablo

“…Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple…”
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Strategy to prevent epitope masking in CAR.CD19+ B-cell leukemia blasts by Quintarelli, Concetta, Guercio, Marika, Manni, Simona, Boffa, Iolanda, Sinibaldi, Matilde, Di Cecca, Stefano, Caruso, Simona, Abbaszadeh, Zeinab, Camera, Antonio, Cembrola, Biancamaria, Ciccone, Roselia, Orfao, Alberto, Martin-Martin, Lourdes, Gutierrez-Herrero, Sara, Herrero-Garcia, Maria, Cazzaniga, Gianni, Nunes, Vittorio, Songia, Simona, Marcatili, Paolo, Marin, Frederikke I, Ruella, Marco, Bertaina, Valentina, Vinti, Luciana, Del Bufalo, Francesca, Algeri, Mattia, Merli, Pietro, De Angelis, Biagio, Locatelli, Franco

“…Chimeric antigen receptor T-cells (CAR T-cells) for the treatment of relapsing/refractory B-cell precursor acute lymphoblastic leukemia have led to exciting…”
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P337: IKZF1 DELETIONS IN B‐ALL: FROM ITS GENETIC BASIS TO DIAGNOSTIC ENHANCEMENT by Lopes, Bruno A., Meyer, Claus, Bouzada, Heloysa, Külp, Marius, Luiza Tardem Maciel, Ana, Larghero, Patrizia, Da Conceição Barbosa, Thayana, Poubel, Caroline P., Barbieri, Caroline, Venn, Nicola C., Dalla‐Pozza, Luciano, Barbaric, Draga, Palmi, Chiara, Fazio, Grazia, Saitta, Claudia, Ferraz Aguiar, Thais, Lins, Mecneide M., Ikoma, Maura R. V., Schramm, Marcia, Chapchap, Eduardo, Cazzaniga, Gianni, Sutton, Rosemary, Marschalek, Rolf, Emerenciano, Mariana

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IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia by Lopes, Bruno A., Meyer, Claus, Barbosa, Thayana C., Poubel, Caroline P., Mansur, Marcela B., Duployez, Nicolas, Bashton, Matthew, Harrison, Christine J., zur Stadt, Udo, Horstmann, Martin, Pombo-de-Oliveira, Maria S., Palmi, Chiara, Cazzaniga, Gianni, Venn, Nicola C., Sutton, Rosemary, Alonso, Cristina N., Tsaur, Grigory, Gupta, Sanjeev K., Bakhshi, Sameer, Marschalek, Rolf, Emerenciano, Mariana

“…IKZF1 deletion (ΔIKZF1) is an important predictor of relapse in both childhood and adult B-cell precursor acute lymphoblastic leukemia (B-ALL). Previously, we…”
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