Search Results - "Cawston, Timothy E"

Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption by Young, David A, Lakey, Rachel L, Pennington, Caroline J, Jones, Debra, Kevorkian, Lara, Edwards, Dylan R, Cawston, Timothy E, Clark, Ian M

“…Cartilage destruction in the arthritides is thought to be mediated by two main enzyme families: the matrix metalloproteinases (MMPs) are responsible for…”
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Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients by Murphy, Desmond M, Forrest, Ian A, Corris, Paul A, Johnson, Gail E, Small, Therese, Jones, Debbie, Fisher, Andrew J, Egan, Jim J, Cawston, Timothy E, Ward, Chris, Lordan, James L

“…Obliterative bronchiolitis (OB), the major cause of chronic lung allograft dysfunction, is characterized by airway neutrophilia, inflammation, and remodeling,…”
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Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis by Milner, Jennifer M, Kevorkian, Lara, Young, David A, Jones, Debra, Wait, Robin, Donell, Simon T, Barksby, Emma, Patterson, Angela M, Middleton, Jim, Cravatt, Benjamin F, Clark, Ian M, Rowan, Andrew D, Cawston, Timothy E

“…Arthritis is characterised by the proteolytic degradation of articular cartilage leading to a loss of joint function. Articular cartilage is composed of an…”
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Azithromycin Attenuates Effects of Lipopolysaccharide on Lung Allograft Bronchial Epithelial Cells by Murphy, Desmond M., MRCP, PhD, Forrest, Ian A., MRCP, Corris, Paul A., FRCP, Johnson, Gail E., FIBMS, Small, Therese, RCCP, Jones, Debbie, BSc, Fisher, Andrew J., MRCP, Egan, Jim J., MRCP, Cawston, Timothy E., PhD, Lordan, James L., MRCP, Ward, Chris, PhD

“…Background The bronchial epithelium is a source of mediators that may play a role in the airway inflammation and remodeling of post-transplant obliterative…”
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The Effects of Cyclosporin on the Collagenolytic Activity of Gingival Fibroblasts by Hyland, Paula L., Traynor, Patrick S., Myrillas, Theofilos T., Marley, John J., Linden, Gerard J., Winter, Paul, Leadbetter, Nicola, Cawston, Timothy E., Irwin, Chris R.

“…Background: The immunosuppressive agent cyclosporin is associated with a number of major side‐effects including the development of gingival overgrowth…”
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The Role of Soluble Interleukin (IL)‐6 Receptor in Mediating the effects of IL‐6 on Matrix Metalloproteinase‐1 and Tissue Inhibitor of Metalloproteinase‐1 Expression by Gingival Fibroblasts by Irwin, Chris R., Myrillas, Theofilos T., Traynor, Patrick, Leadbetter, Nicola, Cawston, Timothy E.

“…Background: Interleukin‐6 (IL‐6) is a multifunctional cytokine thought to play a role in the tissue destruction that characterizes periodontal disease. IL‐6…”
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Effect of azithromycin on primary bronchial epithelial cells derived from stable lung allografts by Murphy, Desmond M, Forrest, Ian A, Ward, Chris, Corris, Paul A, Johnson, Gail E, Jones, Debbie, Fisher, Andrew J, Egan, Jim J, Cawston, Timothy E, Lordan, James L

“…Recent studies of the macrolide antibiotic azithromycin in OB, including one from our centre, have reported improved lung function with rescue therapy. 1 The…”
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Tenascin-C and human tendon degeneration by Riley, GP, Harrall, RL, Cawston, TE, Hazleman, BL, Mackie, EJ

“…We investigated the distribution of tenascin in supraspinatus tendons to determine whether an alteration in tenascin expression was associated with human…”
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Preferential binding of collagenase to α2‐macroglobulin in the presence of the tissue inhibitor of metalloproteinases by Cawston, Timothy E., Mercer, Elizabeth

“…The binding of collagenase to both α2‐niacroglobulin and the tissue inhibitor of metalloproteinases was studied using purified materials. Collagenase bound…”
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Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1 by Clark, I M, Rowan, A D, Edwards, D R, Bech-Hansen, T, Mann, D A, Bahr, M J, Cawston, T E

“…The active forms of all of the matrix metalloproteinases (MMPs) are inhibited by a family of specific inhibitors, the tissue inhibitors of metalloproteinases…”
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Preferential binding of collagenase to α 2-macroglobulin in the presence of the tissue inhibitor of metalloproteinases by Cawston, Timothy E., Mercer, Elizabeth

“…The binding of collagenase to both α2-niacroglobulin and the tissue inhibitor of metalloproteinases was studied using purified materials. Collagenase bound…”
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Tissue inhibitor of metalloproteinases: serum levels during pregnancy and labor, term and preterm by Clark, I M, Morrison, J J, Hackett, G A, Powell, E K, Cawston, T E, Smith, S K

“…To determine the levels in serum of tissue inhibitor of metalloproteinases (TIMP) in pregnancy and to examine the possibility of a time course in relation to…”
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Preparation of recombinant tissue inhibitor of metalloproteinases‐1 (TIMP‐1) in high yield and identification of a hydrophobic surface feature by Hodges, Deborah J., Reid, David G., Rowan, Andrew D., Clark, Ian M., Cawston, Timothy E.

“…The work presented here describes an effective method for refolding recombinant tissue inhibitor of metalloproteinases‐1 (TIMP‐1), a 21‐kDa protein with six…”
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Tissue collagenase: serum levels during pregnancy and parturition by Morrison, J J, Clark, I M, Powell, E K, Cawston, T E, Hackett, G A, Smith, S K

“…Serum levels of tissue collagenase, matrix metalloproteinase-1, were measured in both longitudinal and cross-sectional studies, in 332 pregnant women and 27…”
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Human lung mast cell tryptase fails to activate procollagenase or degrade proteoglycan by Johnson, D A, Cawston, T E

“…Pig synovial and human skin fibroblast procollagenases were treated with highly purified tryptase, the major proteinase of human mast cells, to determine…”
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