Search Results - "Cawello, W"

Lacosamide cardiac safety: a thorough QT/QTc trial in healthy volunteers by Kropeit, D., Johnson, M., Cawello, W., Rudd, G. D., Horstmann, R.

“…Objective To determine whether lacosamide prolongs the corrected QT interval (QTc). Materials and methods In this randomized, double‐blind, positive‐ and…”
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Thorough QT/QTc Study in Patients With Advanced Parkinson's Disease: Cardiac Safety of Rotigotine by Malik, M, Andreas, J‐O, Hnatkova, K, Hoeckendorff, J, Cawello, W, Middle, M, Horstmann, R, Braun, M

“…The potential effects of the dopamine agonist rotigotine on cardiac repolarization were studied in patients with Parkinson's disease, which affects…”
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196 Low potential for drug–drug-interaction of lacosamide by Thomas, D., Scharfenecker, U., Nickel, B., Doty, P., Cawello, W., Horstmann, R.

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Connection of pharmacokinetics and pharmacodynamics--how does it work? by Cawello, W

“…The present article gives an introduction to the correlation between drug transports and drug action in a body system. Direct linked model uses the law of mass…”
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Moexipril shows a long duration of action related to an extended pharmacokinetic half-life and prolonged ACE inhibition by Cawello, W, Boekens, H, Waitzinger, J, Miller, U

“…To characterize the lipophilic ACE inhibitor moexipril and its active metabolite moexiprilat regarding the duration of action, the susceptibility of the…”
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Metabolism and pharmacokinetics of prostaglandin E1 administered by intravenous infusion in human subjects by CAWELLO, W, SCHWEER, H, MÜLLER, R, BONN, R, SEYBERTH, H. W

“…In a single-blind, randomized, two-way cross-over study with 12 healthy male volunteers, 60 micrograms of prostaglandin E1 (PGE1) or placebo was administered…”
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Dose proportional pharmacokinetics of alprostadil (prostaglandin E1) in healthy volunteers following intravenous infusion by Cawello, W., Leonhardt, A., Schweer, H., Seyberth, HW, Bonn, R., Lomeli, AL

“…Prostaglandin E1 (PGE1) (30, 60, 120 micrograms) was administered by intravenous infusion over a 120 min period in an open, three way randomized, cross‐over…”
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Lacosamide Has No Effect on the Enzymatic Activity of CYP3A4 (P01.076) by Cawello, W., Surmann, E., Waitzinger, J.

“…Abstract only…”
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The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate by KNAUF, H, CAWELLO, W, SCHMIDT, G, MUTSCHLER, E

“…The effect of the thiazide diuretic, bemetizide, on the excretion of Na+, K+, Cl-, Ca2+, and Mg2+ in relation to the glomerular filtration rate (GFR) was…”
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P57 Filling the gap for children with heart failure: the EU-funded drug development program LENA (labeling of enalapril from neonates up to adolescents) by Laeer, S, Breitkreutz, J, Klingmann, I, Lagler, F, Dalinghaus, M, Bajcetic, M, de Wildt, S, Clark, AK, Breur, H, Male, C, Jovanovic, I, Djukic, M, Mir, TS, Szatmári, A, Vukomanovi, V, Ablonczy, L, Burckhardt, BB, Cawello, W, Kleine, K, Obarcanin, E, Spatenkova, L, Swoboda, V, Van der Meulen, M, Wagner, P, Walsh, J

“…BackgroundACE-inhibitors are first choice treatment for adult and paediatric patients with heart failure. Since there are no systematic data on…”
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Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics by Faisal, Muhammad, Cawello, Willi, Burckhardt, Bjoern B, Laer, Stephanie

“…Comparative pharmacokinetic (PK) data analysis of drugs administered using developed child-appropriate and market authorized dosage formulation is sparse and…”
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Low Lacosamide Plasma Protein Binding in Lacosamide-Naive Patients (P01.077) by Fountain, N., Staelens, L., Tytgat, D., Rudd, G. D., Jacques, P., Cawello, W.

“…Abstract only…”
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Lack of a pharmacokinetic interaction between moexipril and hydrochlorothiazide by HUTT, V, MICHAELIS, K, VERBESSELT, R, DE SCHEPPER, P. J, SALOMON, P, BONN, R, CAWELLO, W, ANGEHRN, J. C

“…To investigate the potential for pharmacokinetic interactions between moexipril, a new converting enzyme inhibitor, and hydrochlorothiazide after single dose…”
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On the metabolism of prostaglandin E1 administered intravenously to human volunteers by Peskar, B A, Cawello, W, Rogatti, W, Rudofsky, G

“…We have demonstrated recently the formation of a biologically active metabolite of prostaglandin (PG) E1, 13,14-dihydro-PGE1, during intravenous infusions of…”
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Moexipril does not alter the pharmacokinetics or pharmacodynamics of warfarin by VAN HECKEN, A, VERBESSELT, R, DEPRE, M, TJANDRAMAGA, T. B, ANGEHRN, J, CAWELLO, W, DE SCHEPPER, P. J

“…The potential effect of moexipril, a new converting enzyme inhibitor, on the pharmacokinetics and pharmacodynamics of a single dose of warfarin has been…”
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641 LACOSAMIDE HAS NO POTENTIAL FOR INTERACTION WITH METFORMIN by Schiltmeyer, B., Thomas, D., Cawello, W., Hammes, W., Horstmann, R.

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640 LOW POTENTIAL FOR DRUG-DRUG-INTERACTION OF LACOSAMIDE by Thomas, D., Scharfenecker, U., Schiltmeyer, B., Doty, P., Cawello, W., Horstmann, R.

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Pharmacokinetics of isosorbide-5-nitrate during haemodialysis and peritoneal dialysis by EVERS, J, BONN, R, BOERTZ, A, CAWELLO, W, LUCKOW, V, FEY, M, ABOUDAN, F, DICKMANS, H.-A

“…The pharmacokinetics of isosorbide-5-nitrate (IS-5-N) was studied in ten patients on haemodialysis (HD) after a single oral dose of 20 mg IS-5-N, and in six…”
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Pharmacokinetics of isosorbide-5-nitrate in renal failure by EVERS, J, KRAKAMP, B, KLIMKAIT, W, DICKMANS, H. A, MADDOCK, J, LUCKOW, V, CAWELLO, W, WEISS, M

“…The pharmacokinetics of the antianginal drug isosorbide-5-nitrate (IS-5-N) was studied in 20 patients with varying degrees of chronic renal failure after…”
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Pharmacokinetics of isosorbide dinitrate, isosorbide-2-nitrate and isosorbide-5-nitrate in renal insufficiency after repeated oral dosage by Evers, J, Bonn, R, Boertz, A, Cawello, W, Dickmans, H A, Weiss, M

“…The pharmacokinetics of isosorbide dinitrate (ISDN) and its two active metabolites isosorbide-2-nitrate (IS-2-N) and isosorbide-5-nitrate (IS-5-N) were studied…”
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