Search Results - "Cavino, Katie"

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells by Xin, Yurong, Kim, Jinrang, Ni, Min, Wei, Yi, Okamoto, Haruka, Lee, Joseph, Adler, Christina, Cavino, Katie, Murphy, Andrew J., Yancopoulos, George D., Lin, Hsin Chieh, Gromada, Jesper

“…This study provides an assessment of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells. The system combines microfluidic…”
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Activin A more prominently regulates muscle mass in primates than does GDF8 by Latres, Esther, Mastaitis, Jason, Fury, Wen, Miloscio, Lawrence, Trejos, Jesus, Pangilinan, Jeffrey, Okamoto, Haruka, Cavino, Katie, Na, Erqian, Papatheodorou, Angelos, Willer, Tobias, Bai, Yu, Hae Kim, Jee, Rafique, Ashique, Jaspers, Stephen, Stitt, Trevor, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent…”
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Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice by Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Sun Y., Cheng, Xiping, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are…”
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Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice by Kim, Jinrang, Okamoto, Haruka, Huang, ZhiJiang, Anguiano, Guillermo, Chen, Shiuhwei, Liu, Qing, Cavino, Katie, Xin, Yurong, Na, Erqian, Hamid, Rachid, Lee, Joseph, Zambrowicz, Brian, Unger, Roger, Murphy, Andrew J., Xu, Yan, Yancopoulos, George D., Li, Wen-hong, Gromada, Jesper

“…Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic…”
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Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder by Cavino, Katie, Sung, Biin, Su, Qi, Na, Erqian, Kim, Jinrang, Cheng, Xiping, Gromada, Jesper, Okamoto, Haruka

“…The liver plays a critical role in maintaining ammonia homeostasis. Urea cycle defects, liver injury, or failure and glutamine synthetase (GS) deficiency…”
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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic α-Cells After Glucagon Receptor Inhibition by Kim, Jinrang, Dominguez Gutierrez, Giselle, Xin, Yurong, Cavino, Katie, Sung, Biin, Sipos, Bence, Kloeppel, Guenter, Gromada, Jesper, Okamoto, Haruka

“…Plasma amino acids and their transporters constitute an important part of the feedback loop between the liver and pancreatic α-cell function, and glucagon…”
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Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity by Kleiner, Sandra, Gomez, Daniel, Megra, Bezawit, Na, Erqian, Bhavsar, Ramandeep, Cavino, Katie, Xin, Yurong, Rojas, Jose, Dominguez-Gutierrez, Giselle, Zambrowicz, Brian, Carrat, Gaelle, Chabosseau, Pauline, Hu, Ming, Murphy, Andrew J., Yancopoulos, George D., Rutter, Guy A., Gromada, Jesper

“…SLC30A8 encodes a zinc transporter that is primarily expressed in the pancreatic islets of Langerhans. In β-cells it transports zinc into insulin-containing…”
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Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys by Okamoto, Haruka, Kim, Jinrang, Aglione, JohnPaul, Lee, Joseph, Cavino, Katie, Na, Erqian, Rafique, Ashique, Kim, Jee Hae, Harp, Joyce, Valenzuela, David M, Yancopoulos, George D, Murphy, Andrew J, Gromada, Jesper

“…Antagonizing glucagon action represents an attractive therapeutic option for reducing hepatic glucose production in settings of hyperglycemia where glucagon…”
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Increased SLC38A4 Amino Acid Transporter Expression in Human Pancreatic [alpha]-Cells After Glucagon Receptor Inhibition by Kim, Jinrang, Gutierrez, Giselle Dominguez, Xin, Yurong, Cavino, Katie, Sung, Biin, Sipos, Bence, Kloeppel, Guenter, Gromada, Jesper, Okamoto, Haruka

“…Plasma amino acids and their transporters constitute an important part of the feedback loop between the liver and pancreatic [alpha]-cell function, and…”
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Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature by Xin, Yurong, Okamoto, Haruka, Kim, Jinrang, Ni, Min, Adler, Christina, Cavino, Katie, Na, Erqian, Murphy, Andrew J, Yancopoulos, George D, Lin, Calvin, Gromada, Jesper

“…Aging improves pancreatic β-cell function in mice. This is a surprising finding because aging is typically associated with functional decline. We performed…”
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Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition by Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Steven, Stevis, Panayiotis E., Harp, Joyce, Murphy, Andrew J., Yancopoulos, George D., Gromada, Jesper

“…Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion…”
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Angptl4 does not control hyperglucagonemia or [alpha]-cell hyperplasia following glucagon receptor inhibition by Okamoto, Haruka, Cavino, Katie, Na, Erqian, Krumm, Elizabeth, Kim, Steven, Stevis, Panayiotis E, Harp, Joyce, Murphy, Andrew J, Yancopoulos, George D, Gromada, Jesper

“…Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion…”
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Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder by Cavino, Katie, Sung, Biin, Su, Qi, Na, Erqian, Kim, Jinrang, Cheng, Xiping, Gromada, Jesper, Okamoto, Haruka

“…The liver plays a critical role in maintaining ammonia homeostasis. Urea cycle defects, liver injury, or failure and glutamine synthetase (GS) deficiency…”
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Discovery of Isoxazole Analogues of Sazetidine-A as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists for the Treatment of Depression by Liu, Jianhua, Yu, Li-Fang, Eaton, J. Brek, Caldarone, Barbara, Cavino, Katie, Ruiz, Christina, Terry, Matthew, Fedolak, Allison, Wang, Daguang, Ghavami, Afshin, Lowe, David A, Brunner, Dani, Lukas, Ronald J, Kozikowski, Alan P

“…Depression, a common neurological condition, is one of the leading causes of disability and suicide worldwide. Standard treatment, targeting monoamine…”
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Single-Cell RNAseq Reveals That Pancreatic [beta]-Cells From Very Old Male Mice Have a Young Gene Signature by Xin, Yurong, Okamoto, Haruka, Kim, Jinrang, Ni, Min, Adler, Christina, Cavino, Katie, Na, Erqian, Murphy, Andrew J, Yancopoulos, George D, Lin, Calvin, Gromada, Jesper

“…Aging improves pancreatic [beta]-cell function in mice. This is a surprising finding because aging is typically associated with functional decline. We…”
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Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice by Mastaitis, Jason, Eckersdorff, Mark, Min, Soo, Xin, Yurong, Cavino, Katie, Aglione, Johnpaul, Okamoto, Haruka, Na, Erqian, Stitt, Trevor, Dominguez, Melissa G, Schmahl, Jennifer P, Lin, Calvin, Gale, Nicholas W, Valenzuela, David M, Murphy, Andrew J, Yancopoulos, George D, Gromada, Jesper

“…Secreted frizzled-related protein 4 (SFRP4) is an extracellular regulator of the wingless-type mouse mammary tumor virus integration site family (WNT) pathway…”
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Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380 by Caldarone, Barbara J., Wang, Daguang, Paterson, Neil E., Manzano, Michael, Fedolak, Allison, Cavino, Katie, Kwan, Mei, Hanania, Taleen, Chellappan, Sheela K., Kozikowski, Alan P., Olivier, Berend, Picciotto, Marina R., Ghavami, Afshin

“…Rationale Nicotinic acetylcholine receptor (nAChR) agonists, partial agonists, and antagonists have antidepressant-like effects in rodents and reduce symptoms…”
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Dissociation between duration of action in the forced swim test and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380 by Caldarone, Barbara J., Wang, Daguang, Paterson, Neil E., Manzano, Michael, Fedolak, Allison, Cavino, Katie, Kwan, Mei, Hanania, Taleen, Chellappan, Sheela K., Kozikowski, Alan P., Olivier, Berend, Picciotto, Marina R., Ghavami, Afshin

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