Search Results - "Cavedine, Lee R."

Abstract 4245: Drug response metrics and pharmacological profiling using the OncoPanel™ cell-based profiling service by Wageman, Charles R., Cavedine, Lee R., Norman, Vanessa, Robinson, Natiya, Lu, Tracy, McBain, Victoria, Murphy, Joseph, Stehle, Kayla, Garner, Steven M., Croff, Alyssa M., Epkins, Brogan A., Dempsey, Kristin, King, Alastair J., Parry, Jesse J.

“…Abstract High-throughput, cell-based drug screening platforms are essential to guiding drug discovery programs and can rapidly generate large amounts of…”
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Abstract 2073: Profiling and comparison of breast cancer standard of care agents using the OncoPanel™ cell-based profiling service by King, Alastair J., Cavedine, Lee R., Croff, Alyssa M., Dempsey, Kristin C., Epkins, Brogan A., Garner, Steven M., Lu, Tracy, McBain, Victoria V., Murphy, Joseph W., Norman, Vanessa L., Robinson, Natiya E., Stehle, Kayla A., Wageman, Charles R., Parry, Jesse J.

“…Abstract Oncology drugs with clinical utility for the treatment of breast cancer span a wide range of different mechanisms and cancer type profiles…”
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Abstract 1391: Establishment and validation of a high-content imaging assay with a 14-day incubation for the testing of epigenetic target-based therapeutics by Parry, Jesse J., Norman, Vanessa L., Wageman, Charles R., Cavedine, Lee R., Sindelar, Timothy J., Croff, Alyssa M., Garner, Steven M., Epkins, Brogan A., Robinson, Natiya E., Dempsey, Kristin C., Warrior, Usha, King, Alastair J.

“…Abstract Given the importance and significance of targeting mutations and epigenetic modification in cancer therapy, we sought to expand on our ability to test…”
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Abstract 2260: Exploring drug response metrics for biomarker discovery using the OncoPanel™ cell-based profiling service by Wageman, Charles R., Parry, Jesse J., Cavedine, Lee R., Croff, Alyssa M., Garner, Steven M., Epkins, Brogan A., Robinson, Natiya E., Dempsey, Kristin C., Norman, Vanessa L., Warrior, Usha, King, Alastair J.

“…Abstract Using drug response data, generated by the OncoPanelTM cell-based profiling service, we investigated the differences between traditional and…”
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Abstract 4701: A novel microtubule disruptor exerts broad anticancer efficacy with a tolerable safety profile by Lelie, Herman, Brandsma, Inger, Hendriks, Giel, Cavedine, Lee R., Epkins, Brogan A., Garner, Steven M., Cook, Andrew J., Renganathan, Muthukrishnan, Zhao, Yong, King, Alastair J., Chan, Peter Y.W., Risinger, April, Koutsioumpa, Marina

“…Abstract Initial evaluation of the prenylated hydroxy-stilbene isolated from bee propolis, AUS_001, in the NCI 60 human cell line anticancer screen showed…”
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Abstract 2116: Combining the power of different profiling approaches to better understand the activity of kinase inhibitor drugs by King, Alastair J., Parry, Jesse J., Burkart, Samantha C., Cavedine, Lee R., Cracchiolo, Alyssa M., Epkins, Brogan A., Garner, Steven M., Sindelar, Timothy J., Wageman, Charles R., Davies, Stephen P., Plater, Andrew, Woodward, Anna M., Warrior, Usha

“…Abstract Profiling of inhibitors for eventual therapeutic use is an essential part of drug discovery and development. Evaluating the in vitro potency of kinase…”
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Abstract 5075: Phenotypic human tumor cell line profiling and predictive biomarker analysis for epigenetic inhibitors by Warrior, Usha, Parry, Jesse J., Burkart, Samantha C., Cavedine, Lee R., Cracchiolo, Alyssa M., Epkins, Brogan A., Garner, Steven M., Sindelar, Timothy J., Wageman, Charles R., King, Alastair J.

“…Abstract In recent years, epigenetic target inhibitors have emerged as viable therapeutics for treating various types of cancers. Testing of the epigenetic…”
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Abstract 5787: Validation of spheroids with long-term incubation for high-throughput screening by Parry, Jesse J., Garner, Steven M., Cavedine, Lee R., Cracchiolo, Alyssa M., Epkins, Brogan A., Burkart, Samantha C., Sindelar, Timothy J., Wageman, Charles R., Warrior, Usha, King, Alastair J.

“…Abstract The OncoPanel™ service has established 100 genomically-characterized human tumor cell lines as targets for the screening of compounds in 3D spheroid…”
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Abstract 2769: Qualification of human tumor cell lines for inclusion in the OncoPanel™ cell-based profiling and screening service by Garner, Steven M., Krings, Jillian V., Hoehn, Emily C., Lofton, Erin N., Rose, Lyndsey M., Cavedine, Lee R., Lahm, Brendan M., Collver, Kaleb, Powers, Kaitlyne, Herishen, Lindsey, King, Alastair J.

“…Abstract It is estimated that in the U.S. alone, roughly $200 billion are spent each year on cancer drug discovery. Although this spending is significant, we…”
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