Search Results - "Cavazzuti, Antonio"
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Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development
Published in Proceedings of the National Academy of Sciences - PNAS (05-02-2008)“…Pteridine reductase (PTR1) is essential for salvage of pterins by parasitic trypanosomatids and is a target for the development of improved therapies. To…”
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Therapeutic Efficacy of Stable Analogues of Vasoactive Intestinal Peptide against Pathogens
Published in The Journal of biological chemistry (23-05-2014)“…Vasoactive intestinal peptide (VIP) is an anti-inflammatory neuropeptide recently identified as a potential antimicrobial peptide. To overcome the metabolic…”
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Protective role of the neuropeptide urocortin II against experimental sepsis and leishmaniasis by direct killing of pathogens
Published in The Journal of immunology (1950) (15-12-2013)“…We currently face an alarming resurgence in infectious diseases characterized by antimicrobial resistance and therapeutic failure. This has generated the…”
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Antibacterial Agent Discovery Using Thymidylate Synthase Biolibrary Screening
Published in Journal of medicinal chemistry (05-10-2006)“…Thymidylate synthase (TS, ThyA) catalyzes the reductive methylation of 2‘-deoxyuridine 5‘-monophosphate to 2‘-deoxythymidine 5‘-monophosphate, an essential…”
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