Search Results - "Cavanagh, Jonathan"

Anti-inflammatory Drugs in the Treatment of Depression by Cavanagh, Jonathan T

“…The last two decades have seen a flourishing of research into the immunobiology of psychiatric phenotypes, in particular major depressive disorder. Both…”
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Rheumatoid arthritis and depression: an inflammatory perspective by Nerurkar, Louis, Siebert, Stefan, McInnes, Iain B, Cavanagh, Jonathan

“…The coexistence of immune-mediated inflammatory diseases with depression has long been recognised. Data that illustrate the intimate associations between…”
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The Systemic Response to Topical Aldara Treatment is Mediated Through Direct TLR7 Stimulation as Imiquimod Enters the Circulation by Nerurkar, Louis, McColl, Alison, Graham, Gerard, Cavanagh, Jonathan

“…Topical application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely used mouse model for investigating the pathogenesis…”
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Indirect evidence of selective glial involvement in glutamate-based mechanisms of mood regulation in depression: Meta-analysis of absolute prefrontal neuro-metabolic concentrations by Arnone, Danilo, Mumuni, Abdul Nashirudeen, Jauhar, Sameer, Condon, Barrie, Cavanagh, Jonathan

“…Abstract Proton magnetic resonance spectroscopy (1 H MRS) measures glutamatergic metabolites namely glutamate and glutamine located in neurons and astrocytes…”
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Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes by Thomson, Carolyn A, McColl, Alison, Graham, Gerard J, Cavanagh, Jonathan

“…Recent years have seen an explosion of research pertaining to biological psychiatry, yet despite subsequent advances in our understanding of neuroimmune…”
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Distinct trans-placental effects of maternal immune activation by TLR3 and TLR7 agonists: implications for schizophrenia risk by Kwon, Jaedeok, Suessmilch, Maria, McColl, Alison, Cavanagh, Jonathan, Morris, Brian J.

“…Exposure to infection in utero predisposes towards psychiatric diseases such as autism, depression and schizophrenia in later life. The mechanisms involved are…”
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Predicting one-year outcome in first episode psychosis using machine learning by Leighton, Samuel P, Krishnadas, Rajeev, Chung, Kelly, Blair, Alison, Brown, Susie, Clark, Suzy, Sowerbutts, Kathryn, Schwannauer, Matthias, Cavanagh, Jonathan, Gumley, Andrew I

“…Early illness course correlates with long-term outcome in psychosis. Accurate prediction could allow more focused intervention. Earlier intervention…”
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Whole-blood expression of inflammasome- and glucocorticoid-related mRNAs correctly separates treatment-resistant depressed patients from drug-free and responsive patients in the BIODEP study by Cattaneo, Annamaria, Ferrari, Clarissa, Turner, Lorinda, Mariani, Nicole, Enache, Daniela, Hastings, Caitlin, Kose, Melisa, Lombardo, Giulia, McLaughlin, Anna P., Nettis, Maria A., Nikkheslat, Naghmeh, Sforzini, Luca, Worrell, Courtney, Zajkowska, Zuzanna, Cattane, Nadia, Lopizzo, Nicola, Mazzelli, Monica, Pointon, Linda, Cowen, Philip J., Cavanagh, Jonathan, Harrison, Neil A., de Boer, Peter, Jones, Declan, Drevets, Wayne C., Mondelli, Valeria, Bullmore, Edward T., Pariante, Carmine M.

“…The mRNA expression signatures associated with the ‘pro-inflammatory’ phenotype of depression, and the differential signatures associated with depression…”
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A systematic review of manic and depressive prodromes by Jackson, Alison, Cavanagh, Jonathan, Scott, Jan

“…Background: This paper explores whether individuals with a mood disorder can identify the nature and duration of depressive and manic prodromes. Methods:…”
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Work environment discomfort and injury: an ergonomic survey study of the American Society of Pediatric Otolaryngology members by Cavanagh, Jonathan, MD, MSc, Brake, Maria, MD, Kearns, Donald, MD, Hong, Paul, MD, FRCSC

“…Abstract Background Workplace-related musculoskeletal pain has been studied in various occupations, but it is rarely reported in the surgical literature…”
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JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk by Openshaw, Rebecca L, Kwon, Jaedeok, McColl, Alison, Penninger, Josef M, Cavanagh, Jonathan, Pratt, Judith A, Morris, Brian J

“…Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining…”
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Depression and anxiety in an early rheumatoid arthritis inception cohort. associations with demographic, socioeconomic and disease features by Fragoulis, George E, Cavanagh, Jonathan, Tindell, Alistair, Derakhshan, Mohammad, Paterson, Caron, Porter, Duncan, McInnes, Iain B, Siebert, Stefan

“…ObjectiveDepression and anxiety are not uncommon in Rheumatoid arthritis (RA). It is increasingly recognised that they are associated with high disease…”
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No evidence for differential gene expression in major depressive disorder PBMCs, but robust evidence of elevated biological ageing by Cole, John J., McColl, Alison, Shaw, Robin, Lynall, Mary-Ellen, Cowen, Philip J., de Boer, Peter, Drevets, Wayne C., Harrison, Neil, Pariante, Carmine, Pointon, Linda, Goodyear, Carl, Bullmore, Edward, Cavanagh, Jonathan

“…The increasingly compelling data supporting the involvement of immunobiological mechanisms in Major Depressive Disorder (MDD) might provide some explanation…”
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Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study by Sforzini, Luca, Cattaneo, Annamaria, Ferrari, Clarissa, Turner, Lorinda, Mariani, Nicole, Enache, Daniela, Hastings, Caitlin, Lombardo, Giulia, Nettis, Maria A., Nikkheslat, Naghmeh, Worrell, Courtney, Zajkowska, Zuzanna, Kose, Melisa, Cattane, Nadia, Lopizzo, Nicola, Mazzelli, Monica, Pointon, Linda, Cowen, Philip J., Cavanagh, Jonathan, Harrison, Neil A., Jones, Declan, Drevets, Wayne C., Mondelli, Valeria, Bullmore, Edward T., Pariante, Carmine M.

“…Compelling evidence demonstrates that some individuals suffering from major depressive disorder (MDD) exhibit increased levels of inflammation. Most studies…”
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Accelerated telomere attrition is associated with relative household income, diet and inflammation in the pSoBid cohort by Shiels, Paul G, McGlynn, Liane M, MacIntyre, Alan, Johnson, Paul C D, Batty, G David, Burns, Harry, Cavanagh, Jonathan, Deans, Kevin A, Ford, Ian, McConnachie, Alex, McGinty, Agnes, McLean, Jennifer S, Millar, Keith, Sattar, Naveed, Tannahill, Carol, Velupillai, Yoga N, Packard, Chris J

“…It has previously been hypothesized that lower socio-economic status can accelerate biological ageing, and predispose to early onset of disease. This study…”
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Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain by Dunai, Cordelia, Hetherington, Claire, Boardman, Sarah A, Clark, Jordan J, Sharma, Parul, Subramaniam, Krishanthi, Tharmaratnam, Kukatharmini, Needham, Edward J, Williams, Robyn, Huang, Yun, Wood, Greta K, Collie, Ceryce, Fower, Andrew, Fox, Hannah, Ellul, Mark A, Held, Marie, Egbe, Franklyn N, Griffiths, Michael, Solomon, Tom, Breen, Gerome, Kipar, Anja, Cavanagh, Jonathan, Irani, Sarosh R, Vincent, Angela, Stewart, James P, Taams, Leonie S, Menon, David K, Michael, Benedict D

“…Neurological complications, including encephalopathy and stroke, occur in a significant proportion of COVID-19 cases but viral protein is seldom detected in…”
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Challenges and implications of routine depression screening for depression in chronic disease and multimorbidity: a cross sectional study by Jani, Bhautesh Dinesh, Purves, David, Barry, Sarah, Cavanagh, Jonathan, McLean, Gary, Mair, Frances S

“…Depression screening in chronic disease is advocated but its impact on routine practice is uncertain. We examine the effects of a programme of incentivised…”
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Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland by Green, Claire, Stolicyn, Aleks, Harris, Mathew A., Shen, Xueyi, Romaniuk, Liana, Barbu, Miruna C., Hawkins, Emma L., Wardlaw, Joanna M., Steele, J. Douglas, Waiter, Gordon D., Sandu, Anca-Larisa, Campbell, Archie, Porteous, David J., Seckl, Jonathan R., Lawrie, Stephen M., Reynolds, Rebecca M., Cavanagh, Jonathan, McIntosh, Andrew M., Whalley, Heather C.

“…Hypothalamic–pituitary–adrenal (HPA) axis dysregulation has been commonly reported in major depressive disorder (MDD), but with considerable heterogeneity of…”
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The role of cytokines in modulating learning and memory and brain plasticity by Bourgognon, Julie-Myrtille, Cavanagh, Jonathan

“…Cytokines are proteins secreted in the central nervous system by neurons, microglia, astrocytes and infiltrating peripheral immune cells under physiological…”
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Early life socioeconomic adversity is associated in adult life with chronic inflammation, carotid atherosclerosis, poorer lung function and decreased cognitive performance: a cross-sectional, population-based study by Packard, Chris J, Bezlyak, Vladimir, McLean, Jennifer S, Batty, G David, Ford, Ian, Burns, Harry, Cavanagh, Jonathan, Deans, Kevin A, Henderson, Marion, McGinty, Agnes, Millar, Keith, Sattar, Naveed, Shiels, Paul G, Velupillai, Yoga N, Tannahill, Carol

“…Socioeconomic gradients in health persist despite public health campaigns and improvements in healthcare. The Psychosocial and Biological Determinants of…”
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