Changes in bone Pb accumulation: Cause and effect of altered bone turnover

Abstract This paper assesses the magnitude of Pb uptake in cortical and trabecular bones in healthy animals and animals with altered balance in bone turnover, and the impact of exposure to Pb on serum markers of bone formation and resorption. The results reported herein provide physiological evidenc...

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Bibliographic Details
Published in:	Bone (New York, N.Y.) Vol. 64; pp. 228 - 234
Main Authors:	Brito, José A.A, Costa, Isabel M, e Silva, Alexandra Maia, Marques, José M.S, Zagalo, Carlos M, Cavaleiro, Inês I.B, Fernandes, Tânia A.P, Gonçalves, Luísa L
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01-07-2014 Elsevier
Subjects:	Animals Biological and medical sciences Biomarkers - metabolism Bone and Bones - metabolism Bone Remodeling Bone turnover Diseases of the osteoarticular system Female Fundamental and applied biological sciences. Psychology Half-Life Kinetic models Lead - metabolism Lead - pharmacokinetics Medical sciences Orthopedics Osteoporosis Osteoporosis. Osteomalacia. Paget disease Pb exposure Rats Rats, Wistar Skeleton and joints Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: osteoarticular system, musculoskeletal system Osteoporosis Pb exposure Bone turnover Kinetic models Morphology Diseases of the osteoarticular system Models Kinetics Bone Bone remodeling
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Summary:	Abstract This paper assesses the magnitude of Pb uptake in cortical and trabecular bones in healthy animals and animals with altered balance in bone turnover, and the impact of exposure to Pb on serum markers of bone formation and resorption. The results reported herein provide physiological evidence that Pb distributes differently in central compartments in Pb metabolism, such as cortical and trabecular bones, in healthy animals and animals with altered balance in bone turnover, and that exposure to Pb does have an impact on bone resorption resulting in OC-dependent osteopenia. These findings show that Pb may play a role in the etiology of osteoporosis and that its concentration in bones varies as a result of altered bone turnover characteristic of this disease, a long standing question in the field. In addition, data collected in this study are consistent with previous observations of increased half-life of Pb in bone at higher exposures. This evidence is relevant for the necessary revision of current physiologically based kinetic models for Pb in humans.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	8756-3282 1873-2763
DOI:	10.1016/j.bone.2014.04.021