Conversion of the C3 component of complement in sera of hanseniasis patients

The levels of total C3 (native C3 plus its degradation products) and the degree of conversion of native C3 into its breakdown products were studied in sera of Virchowian (V), tuberculoid (T), indeterminate (I), and Virchowian with erythema nodosum Hansenicum (ENH) patients. Sera from normal individu...

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Bibliographic Details
Published in:	Hansenologia internationalis Vol. 8; no. 1; p. 5
Main Authors:	Kliemann, T A, Martinez, E L, Irulegui, I, de Souza, Z W, Cavalcanti, Z M
Format:	Journal Article
Language:	English
Published:	Brazil Instituto Lauro de Souza Lima 01-06-1983
Subjects:	Antigen-Antibody Complex - immunology Complement 3 Complement Activation Complement C3 - metabolism Hanseniasi Humans Immunodiffusion Immunoelectrophoresis Leprosy - immunology
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Summary:	The levels of total C3 (native C3 plus its degradation products) and the degree of conversion of native C3 into its breakdown products were studied in sera of Virchowian (V), tuberculoid (T), indeterminate (I), and Virchowian with erythema nodosum Hansenicum (ENH) patients. Sera from normal individuals (N) were also analysed. While the levels of total C3 were not significantly different among the groups, the percentage of conversion of C3 into its degradation products was significantly higher in V and ENH sera. The activation of the complement system and the involvement of immune complexes (IC) are discussed.
ISSN:	0100-3283 1982-5161
DOI:	10.47878/hi.1983.v8.35578