Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats
Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wis...
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Published in: | Phytotherapy research Vol. 23; no. 9; pp. 1276 - 1280 |
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Main Authors: | , , , , , , , , , , |
Format: | Journal Article |
Language: | English |
Published: |
Chichester, UK
John Wiley '' Sons, Ltd
01-09-2009
John Wiley & Sons, Ltd Wiley |
Subjects: | |
Online Access: | Get full text |
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Summary: | Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. Copyright © 2009 John Wiley '' Sons, Ltd. |
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Bibliography: | http://dx.doi.org/10.1002/ptr.2646 ArticleID:PTR2646 ark:/67375/WNG-S04LV0CF-3 istex:671F02C3B61FE8BCA106ECF4EB89AD70640B63D2 Conselho Nacional de Pesquisa (CNPq); Universidade Federal de Pernambuco (UFPE). |
ISSN: | 0951-418X 1099-1573 |
DOI: | 10.1002/ptr.2646 |