Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats

Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wis...

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Published in:Phytotherapy research Vol. 23; no. 9; pp. 1276 - 1280
Main Authors: de Almeida, Edvaldo Rodrigues, Lucena, Flávia Raquel Santos, Silva, Camilla Vila Nova Soares, da Silva Costa-Junior, Wilson, Cavalcanti, Jouse Bezerra, Couto, Gerald Bosco Lindoso, da Silva, Luiz Lúcio Soares, da Mota, Diógenes Luís, da Silveira, Alex Benício, de Sousa Filho, Samuel Daniel, da Silva, Aldo Cezar Passilongo
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley '' Sons, Ltd 01-09-2009
John Wiley & Sons, Ltd
Wiley
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Summary:Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. β-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations. Copyright © 2009 John Wiley '' Sons, Ltd.
Bibliography:http://dx.doi.org/10.1002/ptr.2646
ArticleID:PTR2646
ark:/67375/WNG-S04LV0CF-3
istex:671F02C3B61FE8BCA106ECF4EB89AD70640B63D2
Conselho Nacional de Pesquisa (CNPq); Universidade Federal de Pernambuco (UFPE).
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.2646