Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients

Association between endothelial biomarkers and lipid and glycemic levels: a cross-sectional study with diabetic patients

Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics. To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics. Cross-sectional study that evaluated lipid and glycemic levels and biomarkers...

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Bibliographic Details
Published in:Biomarkers in medicine Vol. 17; no. 22; pp. 935 - 946
Main Authors: Medina Néri, Ane Karoline, Silva, Ricardo Pereira, Meneses, Gdayllon Cavalcante, Costa Martins, Alice Maria, Portela Lima, Ana Ofélia, Callou Filho, Cesário Rui, Cavalcante Vidal, Francisco Daniel, de Oliveira Lima, Jeruza Mara, Rocha, Eduardo Arrais, da Silva Júnior, Geraldo Bezerra
Format: Journal Article
Language:English
Published: England Future Medicine Ltd 01-11-2023
Subjects:
Biomarkers
Blood Glucose
Cholesterol
Cholesterol, HDL
Cross-Sectional Studies
diabetes mellitus
Diabetes Mellitus, Type 2 - complications
FGFs • glycemic control
Glycated Hemoglobin
Humans
lipids
type 2 diabetes
Vascular Cell Adhesion Molecule-1
lipids
FGFs • glycemic control
diabetes mellitus
type 2 diabetes
biomarkers
vascular cell adhesion molecule-1
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Summary:Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics. To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics. Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics. Higher VCAM-1 levels were associated with higher low-density lipoprotein cholesterol and non-high-density lipoprotein (HDL) cholesterol levels (in the group with inadequate glycohemoglobin A1c [HbA1c] levels), with higher glycemic levels (in the group with inadequate HDL cholesterol levels) and with lower HDL cholesterol levels (both groups). VCAM-1 was independently associated with not achieving adequate HbA1c levels. In uncontrolled diabetics, VCAM-1 was independently associated with having inadequate HbA1c levels, suggesting they may already have endothelial damage.
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ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2023-0174