Cellular and Molecular Immune Response to Chikungunya Virus Infection

Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the...

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Bibliographic Details
Published in:	Frontiers in cellular and infection microbiology Vol. 8; p. 345
Main Authors:	Tanabe, Ithallo S B, Tanabe, Eloiza L L, Santos, Elane C, Martins, Wanessa V, Araújo, Isadora M T C, Cavalcante, Maria C A, Lima, Ana R V, Câmara, Niels O S, Anderson, Leticia, Yunusov, Dinar, Bassi, Ênio J
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 10-10-2018
Subjects:	adaptative immunity Cellular and Infection Microbiology Chikungunya virus immune response immunological markers immunovirology innate immunity innate immunity immune response vaccines Chikungunya virus immunovirology adaptative immunity immunological markers
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Summary:	Chikungunya virus (CHIKV) is a re-emergent arthropod-borne virus (arbovirus) that causes a disease characterized primarily by fever, rash and severe persistent polyarthralgia. In the last decade, CHIKV has become a serious public health problem causing several outbreaks around the world. Despite the fact that CHIKV has been around since 1952, our knowledge about immunopathology, innate and adaptive immune response involved in this infectious disease is incomplete. In this review, we provide an updated summary of the current knowledge about immune response to CHIKV and about soluble immunological markers associated with the morbidity, prognosis and chronicity of this arbovirus disease. In addition, we discuss the progress in the research of new vaccines for preventing CHIKV infection and the use of monoclonal antibodies as a promising therapeutic strategy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Reviewed by: Chad J. Roy, Tulane University School of Medicine, United States; Raul Isea, Fundación Instituto de Estudios Avanzados (IDEA), Venezuela Edited by: Alan G. Goodman, Washington State University, United States These authors have contributed equally to this work This article was submitted to Virus and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
ISSN:	2235-2988 2235-2988
DOI:	10.3389/fcimb.2018.00345