Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp2)–H Bond Selenylation of Imidazo[2,1‑b]thiazole and Related Structures

Urea Hydrogen Peroxide and Ethyl Lactate, an Eco-Friendly Combo System in the Direct C(sp2)–H Bond Selenylation of Imidazo[2,1‑b]thiazole and Related Structures

Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo­[2,1-b]­thiazole by using half molar equivalent diorganyl diselenides in ethyl lactate as a greener solvent. The reaction features high yields, easy performance on gram scale, metal-fr...

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Bibliographic Details
Published in:ACS omega Vol. 8; no. 42; pp. 39535 - 39545
Main Authors: Moraes, Cassio A. O., Santos, Rafaely B. C., Cavalcante, Marcos F. O., Guilhermi, Jhefferson S., Ali, Muhammad A., Botteselle, Giancarlo V., Frizon, Tiago E. A., Shah, Muhammad I. A., Lião, Luciano M., Beatriz, Adilson, Saba, Sumbal, Rafique, Jamal
Format: Journal Article
Language:English
Published: American Chemical Society 24-10-2023
Online Access:Get full text
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Summary:Herein, we describe a urea hydrogen peroxide-mediated sustainable protocol for the synthesis of selenylated imidazo­[2,1-b]­thiazole by using half molar equivalent diorganyl diselenides in ethyl lactate as a greener solvent. The reaction features high yields, easy performance on gram scale, metal-free conditions, as well as applicability to imidazopyridine and imidazopyrimidine.
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ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.3c05338