Major neurotransmitter systems in dorsal hippocampus and basolateral amygdala control social recognition memory

Social recognition memory (SRM) is crucial for reproduction, forming social groups, and species survival. Despite its importance, SRM is still relatively little studied. Here we examine the participation of the CA1 region of the dorsal hippocampus (CA1) and the basolateral amygdala (BLA) and that of...

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Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 33; pp. E4914 - E4919
Main Authors:	Zinn, Carolina Garrido, Clairis, Nicolas, Cavalcante, Lorena Evelyn Silva, Furini, Cristiane Regina Guerino, de Carvalho Myskiw, Jociane, Izquierdo, Ivan
Format:	Journal Article
Language:	English
Published:	United States National Academy of Sciences 16-08-2016
Series:	PNAS Plus
Subjects:	Amygdala - physiology Animals Biological Sciences Brain Hippocampus - physiology Male Memory Memory Consolidation Neurotransmitter Agents - physiology Neurotransmitters PNAS Plus Rats Rats, Wistar Receptors, Adrenergic - physiology Receptors, Dopamine - physiology Receptors, Histamine H2 - physiology Recognition Rodents Social Behavior norepinephrine basolateral amygdala hippocampus dopamine social memory
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Summary:	Social recognition memory (SRM) is crucial for reproduction, forming social groups, and species survival. Despite its importance, SRM is still relatively little studied. Here we examine the participation of the CA1 region of the dorsal hippocampus (CA1) and the basolateral amygdala (BLA) and that of dopaminergic, noradrenergic, and histaminergic systems in both structures in the consolidation of SRM. Male Wistar rats received intra-CA1 or intra-BLA infusions of different drugs immediately after the sample phase of a social discrimination task and 24-h later were subjected to a 5-min retention test. Animals treated with the protein synthesis inhibitor, anisomycin, into either the CA1 or BLA were unable to recognize the previously exposed juvenile (familiar) during the retention test. When infused into the CA1, the β-adrenoreceptor agonist, isoproterenol, the D1/D5 dopaminergic receptor antagonist, SCH23390, and the H2 histaminergic receptor antagonist, ranitidine, also hindered the recognition of the familiar juvenile 24-h later. The latter drug effects were more intense in the CA1 than in the BLA. When infused into the BLA, the β-adrenoreceptor antagonist, timolol, the D1/D5 dopamine receptor agonist, SKF38393, and the H2 histaminergic receptor agonist, ranitidine, also hindered recognition of the familiar juvenile 24-h later. In all cases, the impairment to recognize the familiar juvenile was abolished by the coinfusion of agonist plus antagonist. Clearly, both the CA1 and BLA, probably in that order, play major roles in the consolidation of SRM, but these roles are different in each structure vis-à-vis the involvement of the β-noradrenergic, D1/D5-dopaminergic, and H2-histaminergic receptors therein.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Contributed by Ivan Izquierdo, June 21, 2016 (sent for review May 23, 2016; reviewed by Federico Bermudez-Rattoni and Julietta Frey) 1J.d.C.M. and I.I. contributed equally to this work. Author contributions: C.G.Z., N.C., C.R.G.F., J.d.C.M., and I.I. designed research; C.G.Z., N.C., L.E.S.C., and C.R.G.F. performed research; C.G.Z., N.C., L.E.S.C., C.R.G.F., J.d.C.M., and I.I. analyzed data; and C.G.Z., J.d.C.M., and I.I. wrote the paper. Reviewers: F.B.-R., National University of Mexico; and J.F., Lunds University.
ISSN:	0027-8424 1091-6490
DOI:	10.1073/pnas.1609883113