Search Results - "Caution, Kyle"

Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…Burkholderia cenocepacia ( B. cenocepacia ) is an opportunistic bacterium; causing severe life threatening systemic infections in immunocompromised individuals…”
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Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation by Caution, Kyle, Young, Nicholas, Robledo-Avila, Frank, Krause, Kathrin, Abu Khweek, Arwa, Hamilton, Kaitlin, Badr, Asmaa, Vaidya, Anup, Daily, Kylene, Gosu, Hawin, Anne, Midhun N K, Eltobgy, Mostafa, Dakhlallah, Duaa, Argwal, Sudha, Estfanous, Shady, Zhang, Xiaoli, Partida-Sanchez, Santiago, Gavrilin, Mikhail A, Jarjour, Wael N, Amer, Amal O

“…Gout is characterized by attacks of arthritis with hyperuricemia and monosodium urate (MSU) crystal-induced inflammation within joints. Innate immune responses…”
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Physical activity prevents acute inflammation in a gout model by downregulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammation in gout patients by Jablonski, Kyle, Young, Nicholas A, Henry, Caitlin, Caution, Kyle, Kalyanasundaram, Anuradha, Okafor, Ifeoma, Harb, Peter, Schwarz, Emmy, Consiglio, Paul, Cirimotich, Chris M, Bratasz, Anna, Sarkar, Anasuya, Amer, Amal O, Jarjour, Wael N, Schlesinger, Naomi

“…Gout is the most prevalent inflammatory arthritis. To study the effects of regular physical activity and exercise intensity on inflammation and clinical…”
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Author Correction: Gasdermin D restricts Burkholderia cenocepacia infection in vitro and in vivo by Estfanous, Shady, Krause, Kathrin, Anne, Midhun N. K., Eltobgy, Mostafa, Caution, Kyle, Khweek, Arwa Abu, Hamilton, Kaitlin, Badr, Asmaa, Daily, Kylene, Carafice, Cierra, Baetzhold, Daniel, Zhang, Xiaoli, Li, Tianliang, Wen, Haitao, Gavrilin, Mikhail A., Haffez, Hesham, Soror, Sameh, Amer, Amal O.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis by Abdulrahman, Basant A., Khweek, Arwa Abu, Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Abdelaziz, Dalia H.A., Newland, Christie, Rosales-Reyes, Roberto, Kopp, Benjamin, McCoy, Karen, Montione, Richard, Schlesinger, Larry S., Gavrilin, Mikhail A., Wewers, Mark D., Valvano, Miguel A., Amer, Amal O.

“…Cystic fibrosis (CF) is the most common inherited lethal disease of Caucasians which results in multi organ dysfunction. However, 85% of the deaths are due to…”
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Systemic priming and intranasal booster with a BcfA-adjuvanted acellular pertussis vaccine generates CD4+ IL-17+ nasal tissue resident T cells and reduces B. pertussis nasal colonization by Yount, Kacy S, Hall, Jesse M, Caution, Kyle, Shamseldin, Mohamed M, Guo, Myra, Marion, Keirsten, Fullen, Audra R, Huang, Yimin, Maynard, Jennifer A, Quataert, Sally A, Deora, Rajendar, Dubey, Purnima

“…Resurgence of pertussis, caused by Bordetella pertussis, necessitates novel vaccines and vaccination strategies to combat this disease. Alum-adjuvanted…”
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A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy by Khweek, Arwa A., Caution, Kyle, Akhter, Anwari, Abdulrahman, Basant A., Tazi, Mia, Hassan, Hoda, Majumdar, Neal, Doran, Andrew, Guirado, Evelyn, Schlesinger, Larry S., Shuman, Howard, Amer, Amal O.

“…Legionella pneumophila (L. pneumophila) is an intracellular bacterium of human alveolar macrophages that causes Legionnaires’ disease. In contrast to humans,…”
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Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes by Abdelaziz, Dalia H., Gavrilin, Mikhail A., Akhter, Anwari, Caution, Kyle, Kotrange, Sheetal, Khweek, Arwa Abu, Abdulrahman, Basant A., Grandhi, Jaykumar, Hassan, Zeinab A., Marsh, Clay, Wewers, Mark D., Amer, Amal O.

“…The ability of Legionella pneumophila to cause pneumonia is determined by its capability to evade the immune system and grow within human monocytes and their…”
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Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages by Kotrange, Sheetal, Kopp, Benjamin, Akhter, Anwari, Abdelaziz, Dalia, Abu Khweek, Arwa, Caution, Kyle, Abdulrahman, Basant, Wewers, Mark D., McCoy, Karen, Marsh, Clay, Loutet, Slade A., Ortega, Ximena, Valvano, Miguel A., Amer, Amal O.

“…B. cenocepacia O antigen, host TLR4 and caspase‐1 contribute to IL‐1β production by infected macrophage. Burkholderia cenocepacia infections in CF patients…”
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Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti‐pertussis Vaccine by Wang, Peng, Huo, Chang‐xin, Lang, Shuyao, Caution, Kyle, Nick, Setare Tahmasebi, Dubey, Purnima, Deora, Rajendar, Huang, Xuefei

“…With the infection rate of Bordetella pertussis at a 60‐year high, there is an urgent need for new anti‐pertussis vaccines. The lipopolysaccharide (LPS) of B…”
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Aging is associated with hypermethylation of autophagy genes in macrophages by Khalil, Hany, Tazi, Mia, Caution, Kyle, Ahmed, Amr, Kanneganti, Apurva, Assani, Kaivon, Kopp, Benjamin, Marsh, Clay, Dakhlallah, Duaa, Amer, Amal O.

“…Autophagy is a biological process characterized by self-digestion and involves induction of autophagosome formation, leading to degradation of autophagic…”
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Characterizing the cellular and humoral immune responses to Tdap during pregnancy compared to non-pregnant controls by Hall, Jesse M, Caution, Kyle J, Yuan, Yan, Holt, Kia, Gupta, Yash, Mir, Umul, Stafford, Cameron, Skoff, Tami, Hariri, Susan, Pan, Xueliang, Worly, Brett, Dubey, Purnima

“…Abstract Maternal Tdap vaccination during pregnancy is recommended to protect infants from pertussis, pre-vaccination. However, it is unclear whether maternal…”
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Development of a next generation pertussis vaccine: An unbiased biochemical approach to identify novel CD4+ T cell recognized antigens from Bordetella pertussis by Shamseldin, Mohamed Medhat, Hernandez, Gabrielle, Verzani, Eva, Hall, Jesse M, Caution, Kyle J, Carr, Steven A, Deora, Rajendar, Abbelin, Jenn, Dubey, Purnima

“…Abstract Waning acellular pertussis vaccine (aPV) efficacy has brought about the reemergence of pertussis despite global vaccine coverage. Decreasing vaccine…”
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CASP4/caspase-11 promotes autophagosome formation in response to bacterial infection by Krause, Kathrin, Caution, Kyle, Badr, Asmaa, Hamilton, Kaitlin, Saleh, Abdulmuti, Patel, Khushbu, Seveau, Stephanie, Hall-Stoodley, Luanne, Hegazi, Rana, Zhang, Xiaoli, Gavrilin, Mikhail A., Amer, Amal O.

“…CASP4/caspase-11-dependent inflammasome activation is important for the clearance of various Gram-negative bacteria entering the host cytosol. Additionally,…”
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Chemical Synthesis and Immunological Evaluation of Pertussis-Like Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine by Wang, Peng, Huo, Chang-xin, Lang, Shuyao, Caution, Kyle, Nick, Setare Tahmasebi, Dubey, Purnima, Deora, Rajendar, Huang, Xuefei

“…The 60-year high Bordetella pertussis ( B. pertussis ) infection rate in the world suggests the urgent need for new anti-pertussis vaccines. Lipopolysaccharide…”
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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice by Caution, Kyle, Yount, Kacy, Deora, Rajendar, Dubey, Purnima

“…Vaccines are a 20 century medical marvel. They have dramatically reduced the morbidity and mortality caused by infectious diseases and contributed to a…”
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Caspase-11 and caspase-1 differentially modulate actin polymerization via RhoA and Slingshot proteins to promote bacterial clearance by Caution, Kyle, Gavrilin, Mikhail A., Tazi, Mia, Kanneganti, Apurva, Layman, Daniel, Hoque, Sheshadri, Krause, Kathrin, Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NOD-like receptor family and caspase-1. Caspase-1 is required for the fusion of the…”
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An intricate link between autophagy and microRNAs in cystic fibrosis (HUM1P.262) by Tazi, Mia, Dakhlallah, Duaa, Khalil, Hany, Caution, Kyle, Marsh, Clay

“…Abstract Each year 1,000 children and adults are diagnosed with Cystic Fibrosis (CF), a fatal genetic disorder that critically affects the lungs. Autophagy, a…”
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An Intricate Link between MicroRNAs and Regulation of Autophagy in Cystic Fibrosis by Tazi, Mia, Dakhlallah, Duaa, Caution, Kyle, Marsh, Clay, Amer, Amal

“…Abstract only Each year 1,000 individuals are diagnosed with Cystic Fibrosis (CF), a lethal, inherited disease characterized by severe infection and…”
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Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages by Tazi, Mia F., Dakhlallah, Duaa A., Caution, Kyle, Gerber, Madelyn M., Chang, Sheng-Wei, Khalil, Hany, Kopp, Benjamin T., Ahmed, Amr E., Krause, Kathrin, Davis, Ian, Marsh, Clay, Lovett-Racke, Amy E., Schlesinger, Larry S., Cormet-Boyaka, Estelle, Amer, Amal O.

“…Cystic fibrosis (CF) is a fatal, genetic disorder that critically affects the lungs and is directly caused by mutations in the CF transmembrane conductance…”
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