Search Results - "Caulkett, Peter W.R."

Synthesis and applications of C2-symmetric guanidine bases by Allingham, Matthew T., Howard-Jones, Andrew, Murphy, Patrick J., Thomas, Dafydd A., Caulkett, Peter W.R.

“…The preparation of the tetracyclic C 2-symmetric guanidinium salts 5 and 11– 13 is reported together with their application to enantioselective…”
Get full text

Synthesis, applications and mechanistic investigations of C2 symmetric guanidinium salts by Allingham, Matthew T., Bennett, Elliot L., Davies, Deniol H., Harper, Philip M., Howard-Jones, Andrew, Mehdar, Yassin T.H., Murphy, Patrick J., Thomas, Dafydd A., Caulkett, Peter W.R., Potter, David, Lam, Casey M., O'Donoghue, AnnMarie C.

“…A range of guanidinium catalysts was prepared in six or seven synthetic steps and applied to the phase transfer alkylation of a glycinate Schiff's base in…”
Get full text

Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life by Pike, Kurt G., Allen, Joanne V., Caulkett, Peter W.R., Clarke, David S., Donald, Craig S., Fenwick, Mark L., Johnson, Keith M., Johnstone, Craig, McKerrecher, Darren, Rayner, John W., Walker, Rolf P., Wilson, Ingrid

“…The continued discovery of a novel series of pyridine acid containing glucokinase activators is described. The composite parameter of unbound clearance was…”
Get full text

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy by McKerrecher, Darren, Allen, Joanne V., Caulkett, Peter W.R., Donald, Craig S., Fenwick, Mark L., Grange, Emma, Johnson, Keith M., Johnstone, Craig, Jones, Clifford D., Pike, Kurt G., Rayner, John W., Walker, Rolf P.

“…The optimisation of a series of glucokinase activators is described, including attempts to uncouple the relationship between potency and plasma protein…”
Get full text

Discovery, synthesis and biological evaluation of novel glucokinase activators by McKerrecher, Darren, Allen, Joanne V., Bowker, Suzanne S., Boyd, Scott, Caulkett, Peter W.R., Currie, Gordon S., Davies, Christopher D., Fenwick, Mark L., Gaskin, Harold, Grange, Emma, Hargreaves, Rod B., Hayter, Barry R., James, Roger, Johnson, Keith M., Johnstone, Craig, Jones, Clifford D., Lackie, Sarah, Rayner, John W., Walker, Rolf P.

“…[Display omitted] The identification, synthesis and SAR of a novel series of glucokinase activators is described. The interplay between lipophilicity, potency…”
Get full text

Synthesis of a Novel C2-Symmetric Guanidine Base by HOWARD-JONES, Andrew, MURPHY, Patrick J., THOMAS, Dafydd A., CAULKETT, Peter W. R.

Get full text

(5Z)-7-(2,2-Dimethyl-4-phenyl-1,3-dioxan-cis-5-yl)heptenoic acid: a specific thromboxane A2 receptor antagonist by Brewster, Andrew G, Caulkett, Peter W. R, Jessup, Reg

Get full text