Search Results - "Catterall, William A"

Voltage‐gated sodium channels at 60: structure, function and pathophysiology by Catterall, William A.

“…Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other excitable cells. The sodium current that initiates the nerve action…”
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Sodium channels, inherited epilepsy, and antiepileptic drugs by Catterall, William A

“…Voltage-gated sodium channels initiate action potentials in brain neurons, mutations in sodium channels cause inherited forms of epilepsy, and sodium channel…”
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Structure and function of voltage‐gated sodium channels at atomic resolution by Catterall, William A.

“…New Findings •  What is the topic of this review? The central goal of the research reviewed here is to understand the functional properties of voltage‐gated…”
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The chemical basis for electrical signaling by Catterall, William A, Wisedchaisri, Goragot, Zheng, Ning

“…A highlight of the knowledge derived in large part from structural work on physical motions and chemical interactions involved in voltage sensing, pore…”
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The crystal structure of a voltage-gated sodium channel by Payandeh, Jian, Scheuer, Todd, Zheng, Ning, Catterall, William A.

“…Voltage-gated sodium (Na V ) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the…”
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Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels by Catterall, William A, Lenaeus, Michael J, Gamal El-Din, Tamer M

“…Voltage-gated sodium and calcium channels are evolutionarily related transmembrane signaling proteins that initiate action potentials, neurotransmission,…”
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Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome by Kaplan, Joshua S., Stella, Nephi, Catterall, William A., Westenbroek, Ruth E.

“…Worldwide medicinal use of cannabis is rapidly escalating, despite limited evidence of its efficacy from preclinical and clinical studies. Here we show that…”
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Voltage gated sodium and calcium channels: Discovery, structure, function, and Pharmacology by Catterall, William A

“…Voltage-gated sodium channels initiate action potentials in nerve and muscle, and voltage-gated calcium channels couple depolarization of the plasma membrane…”
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The conformational cycle of a prototypical voltage-gated sodium channel by Catterall, William A., Wisedchaisri, Goragot, Zheng, Ning

“…Electrical signaling was a dramatic development in evolution, allowing complex single-cell organisms like Paramecium to coordinate movement and early metazoans…”
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Signaling complexes of voltage-gated sodium and calcium channels by Catterall, William A.

“…▶ Depolarization and Ca2+ transients generated by Na+ and Ca2+ channels are local signals. ▶ Targeting of effectors and regulatory proteins ensures signaling…”
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Enhancement of Inhibitory Neurotransmission by GABAA Receptors Having α2,3-Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism by Han, Sung, Tai, Chao, Jones, Christina J., Scheuer, Todd, Catterall, William A.

“…Autism spectrum disorder (ASD) may arise from increased ratio of excitatory to inhibitory neurotransmission in the brain. Many pharmacological treatments have…”
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Structural Basis for Pharmacology of Voltage-Gated Sodium and Calcium Channels by Catterall, William A, Swanson, Teresa M

“…Voltage-gated sodium channels initiate action potentials in nerve, muscle, and other electrically excitable cells. Voltage-gated calcium channels are activated…”
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Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel by Wisedchaisri, Goragot, Tonggu, Lige, McCord, Eedann, Gamal El-Din, Tamer M., Wang, Liguo, Zheng, Ning, Catterall, William A.

“…Voltage-gated sodium (NaV) channels initiate action potentials in nerve, muscle, and other electrically excitable cells. The structural basis of voltage gating…”
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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands by Southan, Christopher, Sharman, Joanna L, Benson, Helen E, Faccenda, Elena, Pawson, Adam J, Alexander, Stephen P H, Buneman, O Peter, Davenport, Anthony P, McGrath, John C, Peters, John A, Spedding, Michael, Catterall, William A, Fabbro, Doriano, Davies, Jamie A

“…The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, http://www.guidetopharmacology.org) provides expert-curated molecular interactions between successful and…”
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Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome by Tai, Chao, Abe, Yasuyuki, Westenbroek, Ruth E, Scheuer, Todd, Catterall, William A

“…Haploinsufficiency of the voltage-gated sodium channel Na V1.1 causes Dravet syndrome, an intractable developmental epilepsy syndrome with seizure onset in the…”
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels by Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M, Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Catterall, William A., Conner, Alex C., Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, Fenske, Stefanie, George, Chandy, Goldstein, Steve A. N., Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike, Jensen, Anders A., Kaczmarek, Leonard K., Kellenberger, Stephan, Kennedy, Charles, King, Brian, Kitchen, Philip, Lynch, Joseph W., Perez‐Reyes, Edward, Plant, Leigh D., Rash, Lachlan, Ren, Dejian, Salman, Mootaz M., Sivilotti, Lucia G., Smart, Trevor G., Snutch, Terrance P., Tian, Jinbin, Trimmer, James S., Van den Eynde, Charlotte, Vriens, Joris, Wei, Aguan D., Winn, Brenda T., Wulff, Heike, Xu, Haoxing, Yue, Lixia, Zhang, Xiaoli, Zhu, Michael

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
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Crystal structure of a voltage-gated sodium channel in two potentially inactivated states by Payandeh, Jian, Gamal El-Din, Tamer M., Scheuer, Todd, Zheng, Ning, Catterall, William A.

“…X-ray crystal structures of a bacterial voltage-gated sodium channel in two ‘inactivated’ conformations are reported, revealing several conformational…”
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Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs by Tang, Lin, Gamal El-Din, Tamer M., Swanson, Teresa M., Pryde, David C., Scheuer, Todd, Zheng, Ning, Catterall, William A.

“…Calcium channel blockers are widely used to treat cardiovascular diseases; new structural studies uncover how two different types of calcium-channel blockers…”
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Structural basis for Ca2+ selectivity of a voltage-gated calcium channel by Tang, Lin, Gamal El-Din, Tamer M., Payandeh, Jian, Martinez, Gilbert Q., Heard, Teresa M., Scheuer, Todd, Zheng, Ning, Catterall, William A.

“…Voltage-gated calcium (Ca V ) channels catalyse rapid, highly selective influx of Ca 2+ into cells despite a 70-fold higher extracellular concentration of Na +…”
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Structures of closed and open states of a voltage-gated sodium channel by Lenaeus, Michael J., El-Din, Tamer M. Gamal, Ing, Christopher, Ramanadane, Karthik, Pomès, Régis, Zheng, Ning, Catterall, William A.

“…Bacterial voltage-gated sodium channels (BacNavs) serve as models of their vertebrate counterparts. BacNavs contain conserved voltage-sensing and pore-forming…”
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