Search Results - "Catozzi, Simona"

Predicted ‘wiring landscape’ of Ras-effector interactions in 29 human tissues by Catozzi, Simona, Halasz, Melinda, Kiel, Christina

“…Ras is a plasma membrane (PM)-associated signaling hub protein that interacts with its partners (effectors) in a mutually exclusive fashion. We have shown…”
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Reconstruction and analysis of a large-scale binary Ras-effector signaling network by Catozzi, Simona, Ternet, Camille, Gourrege, Alize, Wynne, Kieran, Oliviero, Giorgio, Kiel, Christina

“…Ras is a key cellular signaling hub that controls numerous cell fates via multiple downstream effector pathways. While pathways downstream of effectors such as…”
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Interspecies and in vitro‐in vivo scaling for quantitative modeling of whole‐body drug pharmacokinetics in patients: Application to the anticancer drug oxaliplatin by Catozzi, Simona, Hill, Roger, Li, Xiao‐Mei, Dulong, Sandrine, Collard, Elodie, Ballesta, Annabelle

“…Quantitative systems pharmacology holds the promises of integrating results from laboratory animals or in vitro human systems into the design of human…”
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Whole-cell energy modeling reveals quantitative changes of predicted energy flows in RAS mutant cancer cell lines by Sevrin, Thomas, Strasser, Lisa, Ternet, Camille, Junk, Philipp, Caffarini, Miriam, Prins, Stella, D’Arcy, Cian, Catozzi, Simona, Oliviero, Giorgio, Wynne, Kieran, Kiel, Christina, Luthert, Philip J.

“…Cellular utilization of available energy flows to drive a multitude of forms of cellular “work” is a major biological constraint. Cells steer metabolism to…”
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Early morning immune checkpoint blockade and overall survival of patients with metastatic cancer: An In-depth chronotherapeutic study by Catozzi, Simona, Assaad, Souad, Delrieu, Lidia, Favier, Bertrand, Dumas, Elise, Hamy, Anne-Sophie, Latouche, Aurélien, Crochet, Hugo, Blay, Jean-Yves, Mullaert, Jimmy, Ballesta, Annabelle, Heudel, Pierre

“…Recent retrospective studies suggest potential large patient’s benefit through proper timing of immune checkpoint blockers (ICB). The association between ICB…”
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Analysis of Ras-effector interaction competition in large intestine and colorectal cancer context by Ibáňez Gaspar, Verónica, Catozzi, Simona, Ternet, Camille, Luthert, Philip J., Kiel, Christina

“…Cancer is the second leading cause of death globally, and colorectal cancer (CRC) is among the five most common cancers. The small GTPase KRAS is an oncogene…”
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Analysis of context-specific KRAS-effector (sub)complexes in Caco-2 cells by Ternet, Camille, Junk, Philipp, Sevrin, Thomas, Catozzi, Simona, Wåhlén, Erik, Heldin, Johan, Oliviero, Giorgio, Wynne, Kieran, Kiel, Christina

“…Ras is a key switch controlling cell behavior. In the GTP-bound form, Ras interacts with numerous effectors in a mutually exclusive manner, where individual…”
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Abstract PO4-13-06: Effect of neoadjuvant dose-dense dose-intense chemotherapy timing infusion on complete histological response rate among patients with triple negative breast cancer (SIMCLOCK) by Bouchez, Clementine, Catozzi, Simona, Cuvier, Caroline, Someil, Laetitia, De Bazelaire, Cedric, Miquel, Catherine, Mhamdi, Nozha, Teixeira, Luis, Espie, Marc, Moati, Emilie, Droin, Leonor, Ballesta, Annabelle, Giacchetti, Sylvie

“…Background: Triple-negative breast cancers (TNBC) exhibit major responses to dose-dense, dose-intense (DD-DI) neoadjuvant chemotherapy (NAC) (1). Although…”
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Signaling cascades transmit information downstream and upstream but unlikely simultaneously by Catozzi, Simona, Di-Bella, Juan Pablo, Ventura, Alejandra C, Sepulchre, Jacques-Alexandre

“…Signal transduction is the process through which cells communicate with the external environment, interpret stimuli and respond to them. This mechanism is…”
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