Search Results - "Catlin, N.R."

Developmental and reproductive toxicity studies in Sprague-Dawley rats and New Zealand white rabbits with palbociclib by Catlin, N.R., Bowman, C.J., Engel, S.M., Sacaan, A., Lewis, E.M., Cappon, G.D.

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Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 Mpro inhibitor in animal models by Catlin, N.R., Bowman, C.J., Campion, S.N., Cheung, J.R., Nowland, W.S., Sathish, J.G., Stethem, C.M., Updyke, L., Cappon, G.D.

“…•No adverse effects of nirmatrelvir on rat fertility or reproduction.•Nirmatrelvir is not teratogenic in rats or rabbits.•No clinically relevant risks…”
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Reproductive and developmental toxicity assessment of palbociclib, a CDK4/6 inhibitor, in Sprague-Dawley rats and New Zealand White rabbits by Catlin, N.R., Bowman, C.J., Engel, S.M., Sacaan, A., Thibault, S., Lewis, E.M., Cappon, G.D.

“…•Palbociclib was not teratogenic in rats or rabbits.•Palbociclib caused no effects on male or female functional fertility.•Seminiferous tubule degeneration was…”
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