Search Results - "Catlett, Natalie L"

Reverse causal reasoning: applying qualitative causal knowledge to the interpretation of high-throughput data by Catlett, Natalie L, Bargnesi, Anthony J, Ungerer, Stephen, Seagaran, Toby, Ladd, William, Elliston, Keith O, Pratt, Dexter

“…Gene expression profiling and other genome-scale measurement technologies provide comprehensive information about molecular changes resulting from a chemical…”
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Whole-Genome Analysis of Two-Component Signal Transduction Genes in Fungal Pathogens by Catlett, Natalie L, Yoder, Olen C, Turgeon, B Gillian

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Training and evaluation corpora for the extraction of causal relationships encoded in biological expression language (BEL) by Fluck, Juliane, Madan, Sumit, Ansari, Sam, Kodamullil, Alpha T, Karki, Reagon, Rastegar-Mojarad, Majid, Catlett, Natalie L, Hayes, William, Szostak, Justyna, Hoeng, Julia, Peitsch, Manuel

“…Success in extracting biological relationships is mainly dependent on the complexity of the task as well as the availability of high-quality training data…”
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Comparative transcriptional network modeling of three PPAR-α/γ co-agonists reveals distinct metabolic gene signatures in primary human hepatocytes by Deehan, Renée, Maerz-Weiss, Pia, Catlett, Natalie L, Steiner, Guido, Wong, Ben, Wright, Matthew B, Blander, Gil, Elliston, Keith O, Ladd, William, Bobadilla, Maria, Mizrahi, Jacques, Haefliger, Carolina, Edgar, Alan

“…To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-α/γ agonist, aleglitazar, with…”
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Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole by Weisman, Lois S, Tang, Fusheng, Kauffman, Emily J, Novak, Jennifer L, Nau, Johnathan J, Catlett, Natalie L

“…Normal cellular function requires that organelles be positioned in specific locations. The direction in which molecular motors move organelles is based in part…”
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Identification of an Organelle-Specific Myosin V Receptor by Ishikawa, Kuniko, Catlett, Natalie L., Novak, Jennifer L., Tang, Fusheng, Nau, Johnathan J., Weisman, Lois S.

“…Class V myosins are widely distributed among diverse organisms and move cargo along actin filaments. Some myosin Vs move multiple types of cargo, where the…”
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The terminal tail region of a yeast myosin-V mediates its attachment to vacuole membranes and sites of polarized growth by Catlett, N.L. (University of Iowa, Iowa City.), Weisman, L.S

“…The Saccharomyces cerevisiae myosin-V, Myo2p, has been implicated in the polarized movement of several organelles and is essential for yeast viability. We have…”
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Divide and multiply: organelle partitioning in yeast by Catlett, Natalie L, Weisman, Lois S

“…The mechanisms ensuring accurate partitioning of yeast vacuoles and mitochondria are distinct, yet they share common elements. Both organelles move along actin…”
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Two Distinct Regions in a Yeast Myosin-V Tail Domain Are Required for the Movement of Different Cargoes by Catlett, Natalie L., Duex, Jason E., Tang, Fusheng, Weisman, Lois S.

“…The Saccharomyces cerevisiae myosin-V, Myo2p, is essential for polarized growth, most likely through transport of secretory vesicles to the developing bud…”
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A Point Mutation in the Cargo-Binding Domain of Myosin V Affects Its Interaction with Multiple Cargoes by Pashkova, Natasha, Catlett, Natalie L, Novak, Jennifer L, Weisman, Lois S

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A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue by Schlage, Walter K, Westra, Jurjen W, Gebel, Stephan, Catlett, Natalie L, Mathis, Carole, Frushour, Brian P, Hengstermann, Arnd, Van Hooser, Aaron, Poussin, Carine, Wong, Ben, Lietz, Michael, Park, Jennifer, Drubin, David, Veljkovic, Emilija, Peitsch, Manuel C, Hoeng, Julia, Deehan, Renee

“…Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors…”
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Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy by Laifenfeld, Daphna, Drubin, David A, Catlett, Natalie L, Park, Jennifer S, Van Hooser, Aaron A, Frushour, Brian P, de Graaf, David, Fryburg, David A, Deehan, Renée

“…The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major…”
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Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole by Wang, Y.X, Catlett, N.L, Weisman, L.S

“…During each cell cycle, the yeast vacuole actively partitions between mother and daughter cells. This process requires actin, profilin, an unconventional…”
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Myosin V attachment to cargo requires the tight association of two functional subdomains by Pashkova, Natasha, Catlett, Natalie L, Novak, Jennifer L, Wu, Guanming, Lu, Renne, Cohen, Robert E, Weisman, Lois S

“…The myosin V carboxyl-terminal globular tail domain is essential for the attachment of myosin V to all known cargoes. Previously, the globular tail was viewed…”
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Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae by Hill, K.L. (University of Iowa, Iowa City, IA.), Catlett, N.L, Weisman, L.S

“…During cell division, cytoplasmic organelles are not synthesized de novo, rather they are replicated and partitioned between daughter cells. Partitioning of…”
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MYC as a candidate upstream controller involved in TYMS gene expression and 5-FU/folate treatment efficacy in colorectal cancer by Drubin, David A., Hess, Anne-Katrin, Catlett, Natalie L., Di Cara, Alessandro, Wettergren, Yvonne, Tell, Roger

“…Abstract only e15512 Background: One of the target enzymes of 5-fluorouracil (5-FU)-based therapies is thymidylate synthase (TS) encoded by the TYMS gene. To…”
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Abstract 4132: Predictive classifiers for response to c-Met targeted therapies in lung and colon cancer by Drubin, David, Catlett, Natalie L., Park, Jennifer, Van Hooser, Aaron A., Frushour, Brian P., Kenney, Renee Deehan

“…Abstract A fundamental challenge in the development of cancer therapies is the co-development of companion biomarkers to select patients most likely to respond…”
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Comparative Transcriptional Network Modeling of Three PPAR-[alpha]/[gamma] Co-Agonists Reveals Distinct Metabolic Gene Signatures in Primary Human Hepatocytes by Deehan, Renée, Maerz-Weiss, Pia, Catlett, Natalie L, Steiner, Guido, Wong, Ben, Wright, Matthew B, Blander, Gil, Elliston, Keith O, Ladd, William, Bobadilla, Maria, Mizrahi, Jacques, Haefliger, Carolina, Edgar, Alan

“…Aims To compare the molecular and biologic signatures of a balanced dual peroxisome proliferator-activated receptor (PPAR)-[alpha]/[gamma] agonist,…”
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Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology by Bonangelino, Cecilia J., Catlett, Natalie L., Weisman, Lois S.

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