Search Results - "Catino, J J"

The Oxidative Mannich Reaction Catalyzed by Dirhodium Caprolactamate by Catino, Arthur J, Nichols, Jason M, Nettles, Brian J, Doyle, Michael P

“…Dirhodium caprolactamate [Rh2(cap)4] is a highly effective catalyst for the oxidative Mannich reaction. The reaction proceeds via C−H oxidation of a tertiary…”
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Benzylic Oxidation Catalyzed by Dirhodium(II,III) Caprolactamate by Catino, Arthur J, Nichols, Jason M, Choi, Hojae, Gottipamula, Sidhartha, Doyle, Michael P

“…Dirhodium caprolactamate [Rh2(cap)4] is an effective catalyst for benzylic oxidation with tert-butyl hydroperoxide (TBHP) under mild conditions. Sodium…”
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Approach to the Tricyclic Core of the Tigliane–Daphnane Diterpenes. Concerning the Utility of Transannular Aldol Additions by Catino, Arthur J, Sherlock, Alexandra, Shieh, Peyton, Wzorek, Joseph S, Evans, David A

“…Two transannular (TA) aldol reactions were used to assemble the tricyclic carbon skeleton found in the tigliane and daphnane classes of diterpene natural…”
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Efficient Aziridination of Olefins Catalyzed by Mixed-Valent Dirhodium(II,III) Caprolactamate by Catino, Arthur J, Nichols, Jason M, Forslund, Raymond E, Doyle, Michael P

“…A mild, efficient, and selective aziridination of olefins catalyzed by dirhodium(II) caprolactamate [Rh2(cap)4·2CH3CN] is described. Use of…”
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K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors by Whyte, David B., Kirschmeier, Paul, Hockenberry, Tish N., Nunez-Oliva, Irma, James, Linda, Catino, Joseph J., Bishop, W. Robert, Pai, Jin-Keon

“…The association of mutant forms of Ras protein with a variety of human cancers has stimulated intense interest in therapies based on inhibiting oncogenic Ras…”
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Dirhodium(II) Caprolactamate:  An Exceptional Catalyst for Allylic Oxidation by Catino, Arthur J, Forslund, Raymond E, Doyle, Michael P

“…The oxidation of organic molecules represents a fundamentally important chemical process. Particularly important is allylic oxidation, whereby a single…”
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice by MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

“…We have been developing a series of nonpeptidic, small molecule farnesyl protein transferase inhibitors that share a common tricyclic nucleus and compete with…”
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Interleukin-10 inhibits tumor metastasis through an NK cell-dependent mechanism by Zheng, L M, Ojcius, D M, Garaud, F, Roth, C, Maxwell, E, Li, Z, Rong, H, Chen, J, Wang, X Y, Catino, J J, King, I

“…Interleukin-10 (IL-10) is a recently described pleiotropic cytokine secreted mainly by type 2 helper T cells. Previous studies have shown that IL-10 suppresses…”
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Activity of temozolomide in the treatment of central nervous system tumor xenografts by FRIEDMAN, H. S, DOLAN, M. E, PEGG, A. E, MARCELLI, S, KEIR, S, CATINO, J. J, BIGNER, D. D, SCHOLD, S. C

“…The activity of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin- 4(3H)-one (temozolomide) in the treatment of a panel of xenografts derived from…”
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A short stereoselective synthesis of (+)- and (−)-2-oxabicyclo[3.3.0]oct-6-en-3-one by intramolecular carbon–hydrogen insertion catalyzed by chiral dirhodium(II) carboxamidates by Doyle, Michael P, Catino, Arthur J

“…The synthesis of (1 S,5 R)-(−)-2-oxabicyclo[3.3.0]oct-6-en-3-one, a useful synthetic precursor en route to various prostaglandins, from divinylcarbinol via…”
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Human smooth muscle α-actin gene is a transcriptional target of the p53 tumor suppressor protein by COMER, K. A, DENNIS, P. A, ARMSTRONG, L, CATINO, J. J, KASTAN, M. B, CHANDRA KUMAR, C

“…Smooth muscle (sm) alpha-actin is expressed in vascular smooth muscle cells and fibroblast cells. Its expression is regulated by cell proliferation and…”
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A Simple Method for the Visualization of Chair and Twist-Boat Transition States in Torsionally Controlled Addition Reactions by Niederer, Kyle A, Fodor, Matthew D, Catino, Arthur J

“…Torsional effects influence kinetic selectivity in a wide range of organic transformations. As such, textbooks commonly use Newman projections to illustrate…”
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Efficacy of p53 adenovirus-mediated gene therapy against human breast cancer xenografts by Nielsen, L L, Dell, J, Maxwell, E, Armstrong, L, Maneval, D, Catino, J J

“…In response to DNA damage, p53 protein accumulates in the cell nucleus causing cells to undergo DNA repair or apoptosis, programmed cell death. Reintroduction…”
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Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex by Taveras, A.G., Remiszewski, S.W., Doll, R.J., Cesarz, D., Huang, E.C., Kirschmeier, P., Pramanik, B.N., Snow, M.E., Wang, Y.-S., del Rosario, J.D., Vibulbhan, B., Bauer, B.B., Brown, J.E., Carr, D., Catino, J., Evans, C.A., Girijavallabhan, V., Heimark, L., James, L., Liberles, S., Nash, C., Perkins, L., Senior, M.M., Tsarbopoulos, A., Ganguly, A.K., Aust, R., Brown, E., Delisle, D., Fuhrman, S., Hendrickson, T., Kissinger, C., Love, R., Sisson, W., Villafranca, E., Webber, S.E.

“…The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide,…”
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Esperamicins, a Class of Potent Antitumor Antibiotics: Mechanism of Action by Long, Byron H., Golik, Jerzy, Forenza, Salvatore, Ward, Brian, Rehfuss, Robert, Dabrowiak, James C., Catino, Joseph J., Musial, Steve T., Brookshire, Kenneth W., Doyle, Terrence W.

“…The esperamicins represent a class of antitumor antibiotics characterized by an unusual chemical core structure and extremely potent cytotoxicity. The…”
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Health sector reform and reproductive health in Latin America and the Caribbean: strengthening the links by Langer, A, Nigenda, G, Catino, J

“…Many countries in Latin America and the Caribbean (LAC) are currently reforming their national health sectors and also implementing a comprehensive approach to…”
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Suppression of Ras transformation by serum response factor by JAE-HONG KIM, JOHANSEN, F.-E, ROBERTSON, N, CATINO, J. J, PRYWES, R, CHANDRA KUMAR, C

“…Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE) found in the promoter regions of a number of…”
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Production and biological activity of rebeccamycin, a novel antitumor agent by Bush, J A, Long, B H, Catino, J J, Bradner, W T, Tomita, K

“…An actinomycete, strain C-38,383, was selected in a screening program for the isolation of novel antitumor agents. A yellow crystalline product, named…”
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Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice by MING LIU, BRYANT, M. S, ROSSMAN, R. R, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, MALLAMS, A. K, DOLL, R. J, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, JIANPING CHEN, SUININHG LEE, YAREMKO, B, ZUJUN LI, DELL, J, LIPARI, P, MALKOWSKI, M, PRIOLI, N

“…The products of the Ha-, Ki-, and N-ras proto-oncogenes comprise a family of 21 kDa guanine nucleotide-binding proteins which play a crucial role in growth…”
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Two serum response elements mediate transcriptional repression of human smooth muscle alpha-actin promoter in ras-transformed cells by Bushel, P, Kim, J H, Chang, W, Catino, J J, Ruley, H E, Kumar, C C

“…The mechanism by which activated ras oncogene expression leads to repression of genes encoding specific actin filament proteins is not understood. However,…”
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