Metabolic syndrome, levels of androgens, and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy

Metabolic syndrome, levels of androgens, and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy

Robust data evaluating the association of preoperative parameters of the patients with quality of life after radical prostatectomy are lacking. We investigated whether clinical and biological preoperative characteristics of the patients were associated with impaired patient-reported quality of life...

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Bibliographic Details
Published in:Asian journal of andrology Vol. 23; no. 4; pp. 370 - 375
Main Authors: Neuzillet, Yann, Rouanne, Mathieu, Dreyfus, Jean-François, Raynaud, Jean-Pierre, Schneider, Marc, Roupret, Morgan, Drouin, Sarah, Galiano, Marc, Cathelinau, Xavier, Lebret, Thierry, Botto, Henry
Format: Journal Article
Language:English
Published: China Wolters Kluwer India Pvt. Ltd 01-07-2021
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer – Medknow
Wolters Kluwer - Medknow
Wolters Kluwer Medknow Publications
Subjects:
Cancer surgery
Erectile dysfunction
Hormones, Sex
Human health and pathology
Impotence
Life Sciences
metabolic syndrome; quality of life; radical prostatectomy; sexual outcomes; testosterone deficiency
Original
Patients
Prostate cancer
Quality of life
Questionnaires
Surgery
Urological surgery
Urology and Nephrology
metabolic syndrome
radical prostatectomy
sexual outcomes
quality of life
testosterone deficiency
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Summary:Robust data evaluating the association of preoperative parameters of the patients with quality of life after radical prostatectomy are lacking. We investigated whether clinical and biological preoperative characteristics of the patients were associated with impaired patient-reported quality of life (QoL) and sexual outcomes 1 year after radical prostatectomy. We evaluated patient-reported outcomes among the 1343 men participating in the AndroCan trial (NCT02235142). QoL and erectile dysfunction (ED) were assessed before and 1 year after radical prostatectomy using validated self-assessment questionnaires (Aging Male's Symptoms [AMS] and the 5-item abridged version of the International Index of Erectile Function [IIEF5]). At baseline, 1194 patients (88.9%) accepted to participate. A total of 750 (55.8%) patients answered the 1-year postoperative questionnaires. Out of them, only 378 (50.4% of responders) provided answers that could be used for calculations. One year after prostatectomy, ED had worsened by 8.0 (95% confidence interval [CI]: 7.3-8.7; P < 0.0001) out of a maximum of 20. The global AMS score has worsened by 2.8 (95% CI: 1.7-3.8; P < 0.0001). ED scores 1 year postsurgery were positively correlated with preoperative age and percentage of fat mass, and negatively correlated with total cholesterol, dehydroepiandrosterone (DHEA), and androstenediol (D5); AMS were poorly correlated with preoperative parameters. QoL and sexual symptoms significantly worsened after radical prostatectomy. Baseline bioavailable testosterone levels were significantly correlated with smaller changes on AMS somatic subscores postprostatectomy. These findings may be used to inform patients with newly diagnosed prostate cancer.
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ISSN:1008-682X
1745-7262
DOI:10.4103/aja.aja_88_20