Search Results - "Cathcart, K S"

Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients by SLATTER, J. G, SCHAAF, L. J, MILLER, L. L, BAKER, D. S, PESHECK, C. V, LORD, R. S, SAMS, J. P, FEENSTRA, K. L, JOHNSON, M. G, BOMBARDT, P. A, CATHCART, K. S, VERBURG, M. T, PEARSON, L. K, COMPTON, L. D

“…This study determined the disposition of irinotecan hydrochloride trihydrate (CPT-11) after i.v. infusion of 125 mg/m 2 (100 μCi) [ 14 C]CPT-11 in eight…”
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Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: I. Single-dose administration by Fleishaker, J C, Peters, G R, Cathcart, K S

“…The single-dose tolerability and pharmacokinetics of tirilazad mesylate, a 21-aminosteroid free radical scavenger, were assessed in 47 healthy male subjects…”
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Evaluation of the pharmacokinetics and tolerability of tirilazad mesylate, a 21-aminosteroid free radical scavenger: II. Multiple-dose administration by Fleishaker, J C, Peters, G R, Cathcart, K S, Steenwyk, R C

“…The multiple dose tolerability and pharmacokinetics of tirilazad mesylate, a 21-aminosteroid free radical scavenger, were assessed in 50 healthy male…”
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Pharmacokinetics of intravenously administered cefmetazole and cefoxitin and effects of probenecid on cefmetazole elimination by KO, H, CATHCART, K. S, GRIFFITH, D. L, PETERS, G. R, ADAMS, W. J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Disposition of cefmetazole in healthy volunteers and patients with impaired renal function by Halstenson, C E, Guay, D R, Opsahl, J A, Hirata, C A, Olanoff, L S, Novak, E, Ko, H, Cathcart, K S, Matzke, G R

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacokinetic and tolerance studies of cefpodoxime after single- and multiple-dose oral administration of cefpodoxime proxetil by Borin, M T, Hughes, G S, Patel, R K, Royer, M E, Cathcart, K S

“…Cefpodoxime proxetil, a third generation, broad-spectrum, oral cephalosporin, was administered in single doses of 100, 200, 400, 600, and 800 mg (dose…”
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An on-line, column-switching high-performance liquid chromatographic procedure for the removal of probenecid from human plasma, serum, or urine in the quantitative determination of cefmetazole or cefoxitin by Bothwell, W M, Cathcart, K S, Bombardt, P A

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Effect of culture-medium temperature on growth of Neisseria gonorrhoeae by Cathcart, S K, Austin, M, Nowak, M L

“…This study was designed to evaluate the effects of culture-medium temperatures on the growth of known quantities of in vitro inoculum of Neisseria gonorrhoeae…”
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Preclinical studies and clinical correlation of the effect of alkylating dose by FREI, E. III, TEICHER, B. A, HOLDEN, S. A, CATHCART, K. N. S, YENYUN WANG

“…Dose-response studies were performed with the alkylating agents [nitrogen mustard, N,N'-bis(2-chloroethyl)-N-nitrosourea, melphalan, cisplatin (CDDP),…”
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Disposition of cefmatazole in healthy volunteers and patients with impaired renal function by HALSTENSON, C. E, GUAY, D. R. P, OPSAHL, J. A, HIRATA, C. A. I, OLANOFF, L. S, NOVAK, E, KO, H, CATHCART, K. S, MATZKE, G. R

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Combination of N,N',N″-triethylenethiophosphoramide and cyclophosphamide in vitro and in vivo by TEICHER, B. A, HOLDEN, S. A, CUCCHI, C. A, CATHCART, K. N. S, KORBUT, T. T, FLATOW, J. L, FREI, E. III

“…In vitro and in vivo studies with the drug combination thioTEPA and cyclophosphamide (CPA) were carried out using the MCF-7 human breast carcinoma cell line…”
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Novobiocin enhances alkylating agent cytotoxicity and DNA interstrand crosslinks in a murine model by EDER, J. P, TEICHER, B. A, HOLDEN, S. A, CATHCART, K. N. S, SCHNIPPER, L. E

“…DNA-DNA crosslinks are the lethal cellular mechanism of bifunctional alkylating agent cytotoxicity. Novobiocin, an inhibitor of DNA topoisomerase II, impairs…”
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Effect of novobiocin on the antitumor activity and tumor cell and bone marrow survivals of three alkylating agents by EDER, J. P, TEICHER, B. A, HOLDEN, S. A, CATHCART, K. N. S, SCHNIPPER, L. E, FREI, E. III

“…Our previous in vitro studies demonstrated marked synergy with alkylating agents when novobiocin was present during and after alkylating agent exposure. To…”
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Effects of various oxygenation conditions on the enhancement by fluosol-DA melphalan antitumor activity by TEICHER, B. A, CRAWFORD, J. M, HOLDEN, S. A, CATHCART, K. N. S

“…The cytotoxicity of melphalan toward exponentially growing FSaIIC fibrosarcoma cells under hypoxia, normal aeration, hyperoxygenation, and stationary phase…”
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Efficacy of Pt(Rh-123)2 as a radiosensitizer with fractionated X rays by Teicher, B A, Holden, S A, Cathcart, K N

“…The complex of tetrachloroplatinate and rhodamine-123, Pt(Rh-123)2 has demonstrated cytotoxic and antitumor effects and radiosensitizing potential in vitro and…”
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Ability of four potential topoisomerase II inhibitors to enhance the cytotoxicity of cis-diamminedichloroplatinum (II) in Chinese hamster ovary cells and in an epipodophyllotoxin-resistant subline by EDER, J. P, TEICHER, B. A, HOLDEN, S. A, SENATOR, L, CATHCART, K. N. S, SCHNIPPER, L. E

“…Four drugs known to interact with topoisomerase II were assessed for their ability to enhance the cytotoxicity of cis-diamminedichloroplatinum(II) (CDDP) in…”
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Effect of hyperthermia on cis-diamminedichloroplatinum(II) (rhodamine 123)2[tetrachloroplatinum(II)] in a human squamous cell carcinoma line and a cis-diammine-dichloroplatinum(II)-resistant subline by HERMAN, T. S, TEICHER, B. A, CATHCART, K. N. S, KAUFMANN, M. E, LEE, J. B, MI-HYON LEE

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The effect of fluosol-DA and oxygenation status on the activity of cyclophosphamide in vivo by TEICHER, B. A, HERMAN, T. S, HOLDEN, S. A, CATHCART, K. N. S

“…The addition of Fluosol-DA followed by carbogen breathing increased the antitumor effect of cyclophosphamide as measured by both tumor growth delay and tumor…”
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Effect of fluosol-DA/carbogen on etoposide/alkylating agent antitumor activity by TEICHER, B. A, BERNAL, S. D, HOLDEN, S. A, CATHCART, K. N. S

“…The tumor growth delay produced by the combination of etoposide with the alkylating agent CDDP or BCNU and Fluosol-DA with carbogen breathing in three model…”
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Some Complexes of Cobalt(III) and Iron(III) Are Radiosensitizers of Hypoxic EMT6 Cells by Teicher, Beverly A., Jacobs, John L., Kathleen N. S. Cathcart, Abrams, Michael J., Vollano, Jean F., Picker, Donald H.

“…The radiosensitizing potential in hypoxic EMT6 cells of several complexes of Co(III) and Fe(III) has been examined. The cytotoxicity of each of the agents…”
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